Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy

Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions i...
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Autor*in:	Wang, Hairong [verfasserIn] Liu, Shiming Jia, Li Chu, Fengyun Zhou, Ya He, Zhixu Guo, Mengmeng Chen, Chao Xu, Lin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Nanostructured lipid carrier (NLC) Tumor MicroRNA

Anmerkung:	© The Author(s) 2018

Übergeordnetes Werk:	Enthalten in: Cancer cell international - London : BioMed Central, 2001, 18(2018), 1 vom: 13. Juli
Übergeordnetes Werk:	volume:18 ; year:2018 ; number:1 ; day:13 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12935-018-0596-x

Katalog-ID:	SPR02859004X

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allfields	10.1186/s12935-018-0596-x doi (DE-627)SPR02859004X (SPR)s12935-018-0596-x-e DE-627 ger DE-627 rakwb eng Wang, Hairong verfasserin aut Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213 Liu, Shiming aut Jia, Li aut Chu, Fengyun aut Zhou, Ya aut He, Zhixu aut Guo, Mengmeng aut Chen, Chao aut Xu, Lin aut Enthalten in Cancer cell international London : BioMed Central, 2001 18(2018), 1 vom: 13. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:18 year:2018 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12935-018-0596-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 13 07
spelling	10.1186/s12935-018-0596-x doi (DE-627)SPR02859004X (SPR)s12935-018-0596-x-e DE-627 ger DE-627 rakwb eng Wang, Hairong verfasserin aut Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213 Liu, Shiming aut Jia, Li aut Chu, Fengyun aut Zhou, Ya aut He, Zhixu aut Guo, Mengmeng aut Chen, Chao aut Xu, Lin aut Enthalten in Cancer cell international London : BioMed Central, 2001 18(2018), 1 vom: 13. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:18 year:2018 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12935-018-0596-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 13 07
allfields_unstemmed	10.1186/s12935-018-0596-x doi (DE-627)SPR02859004X (SPR)s12935-018-0596-x-e DE-627 ger DE-627 rakwb eng Wang, Hairong verfasserin aut Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213 Liu, Shiming aut Jia, Li aut Chu, Fengyun aut Zhou, Ya aut He, Zhixu aut Guo, Mengmeng aut Chen, Chao aut Xu, Lin aut Enthalten in Cancer cell international London : BioMed Central, 2001 18(2018), 1 vom: 13. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:18 year:2018 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12935-018-0596-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 13 07
allfieldsGer	10.1186/s12935-018-0596-x doi (DE-627)SPR02859004X (SPR)s12935-018-0596-x-e DE-627 ger DE-627 rakwb eng Wang, Hairong verfasserin aut Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213 Liu, Shiming aut Jia, Li aut Chu, Fengyun aut Zhou, Ya aut He, Zhixu aut Guo, Mengmeng aut Chen, Chao aut Xu, Lin aut Enthalten in Cancer cell international London : BioMed Central, 2001 18(2018), 1 vom: 13. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:18 year:2018 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12935-018-0596-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 13 07
allfieldsSound	10.1186/s12935-018-0596-x doi (DE-627)SPR02859004X (SPR)s12935-018-0596-x-e DE-627 ger DE-627 rakwb eng Wang, Hairong verfasserin aut Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213 Liu, Shiming aut Jia, Li aut Chu, Fengyun aut Zhou, Ya aut He, Zhixu aut Guo, Mengmeng aut Chen, Chao aut Xu, Lin aut Enthalten in Cancer cell international London : BioMed Central, 2001 18(2018), 1 vom: 13. Juli (DE-627)355989204 (DE-600)2091573-1 1475-2867 nnns volume:18 year:2018 number:1 day:13 month:07 https://dx.doi.org/10.1186/s12935-018-0596-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2018 1 13 07
language	English
source	Enthalten in Cancer cell international 18(2018), 1 vom: 13. Juli volume:18 year:2018 number:1 day:13 month:07
sourceStr	Enthalten in Cancer cell international 18(2018), 1 vom: 13. Juli volume:18 year:2018 number:1 day:13 month:07
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topic_facet	Nanostructured lipid carrier (NLC) Tumor MicroRNA
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authorswithroles_txt_mv	Wang, Hairong @@aut@@ Liu, Shiming @@aut@@ Jia, Li @@aut@@ Chu, Fengyun @@aut@@ Zhou, Ya @@aut@@ He, Zhixu @@aut@@ Guo, Mengmeng @@aut@@ Chen, Chao @@aut@@ Xu, Lin @@aut@@
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author	Wang, Hairong
spellingShingle	Wang, Hairong misc Nanostructured lipid carrier (NLC) misc Tumor misc MicroRNA Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
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topic_title	Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy Nanostructured lipid carrier (NLC) (dpeaa)DE-He213 Tumor (dpeaa)DE-He213 MicroRNA (dpeaa)DE-He213
topic	misc Nanostructured lipid carrier (NLC) misc Tumor misc MicroRNA
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title	Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
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title_full	Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
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author_browse	Wang, Hairong Liu, Shiming Jia, Li Chu, Fengyun Zhou, Ya He, Zhixu Guo, Mengmeng Chen, Chao Xu, Lin
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title_sort	nanostructured lipid carriers for microrna delivery in tumor gene therapy
title_auth	Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
abstract	Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. © The Author(s) 2018
abstractGer	Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. © The Author(s) 2018
abstract_unstemmed	Abstract MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising candidates for tumor gene therapy because of their important biological functions in tumor cell proliferation, metastasis, apoptosis, and drug resistance. As an important delivery system, nanostructured lipid carriers (NLCs) have great potential in tumor gene therapy, particularly for miRNA delivery, due to low toxicity, low immunogenicity, long metabolic cycles, and easy modification. This article reviews recent research progress on NLCs for miRNA delivery in tumor gene therapy and prospective applications. © The Author(s) 2018
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
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title_short	Nanostructured lipid carriers for MicroRNA delivery in tumor gene therapy
url	https://dx.doi.org/10.1186/s12935-018-0596-x
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author2	Liu, Shiming Jia, Li Chu, Fengyun Zhou, Ya He, Zhixu Guo, Mengmeng Chen, Chao Xu, Lin
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