Genetic population structure of Anopheles gambiae in Equatorial Guinea

Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have be...
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Autor*in:	Moreno, Marta [verfasserIn] Salgueiro, Patricia Vicente, José Luis Cano, Jorge Berzosa, Pedro J de Lucio, Aida Simard, Frederic Caccone, Adalgisa Do Rosario, Virgilio E Pinto, João Benito, Agustín

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Malaria Genetic Differentiation Molecular Form Paracentric Inversion Promote Gene Flow

Anmerkung:	© Moreno et al; licensee BioMed Central Ltd. 2007

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 6(2007), 1 vom: 15. Okt.
Übergeordnetes Werk:	volume:6 ; year:2007 ; number:1 ; day:15 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1475-2875-6-137

Katalog-ID:	SPR028600959

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245	1	0	\|a Genetic population structure of Anopheles gambiae in Equatorial Guinea
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520			\|a Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed.
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650		4	\|a Promote Gene Flow \|7 (dpeaa)DE-He213
700	1		\|a Salgueiro, Patricia \|4 aut
700	1		\|a Vicente, José Luis \|4 aut
700	1		\|a Cano, Jorge \|4 aut
700	1		\|a Berzosa, Pedro J \|4 aut
700	1		\|a de Lucio, Aida \|4 aut
700	1		\|a Simard, Frederic \|4 aut
700	1		\|a Caccone, Adalgisa \|4 aut
700	1		\|a Do Rosario, Virgilio E \|4 aut
700	1		\|a Pinto, João \|4 aut
700	1		\|a Benito, Agustín \|4 aut
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allfields	10.1186/1475-2875-6-137 doi (DE-627)SPR028600959 (SPR)1475-2875-6-137-e DE-627 ger DE-627 rakwb eng Moreno, Marta verfasserin aut Genetic population structure of Anopheles gambiae in Equatorial Guinea 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Moreno et al; licensee BioMed Central Ltd. 2007 Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213 Salgueiro, Patricia aut Vicente, José Luis aut Cano, Jorge aut Berzosa, Pedro J aut de Lucio, Aida aut Simard, Frederic aut Caccone, Adalgisa aut Do Rosario, Virgilio E aut Pinto, João aut Benito, Agustín aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 15. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:15 month:10 https://dx.doi.org/10.1186/1475-2875-6-137 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 15 10
spelling	10.1186/1475-2875-6-137 doi (DE-627)SPR028600959 (SPR)1475-2875-6-137-e DE-627 ger DE-627 rakwb eng Moreno, Marta verfasserin aut Genetic population structure of Anopheles gambiae in Equatorial Guinea 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Moreno et al; licensee BioMed Central Ltd. 2007 Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213 Salgueiro, Patricia aut Vicente, José Luis aut Cano, Jorge aut Berzosa, Pedro J aut de Lucio, Aida aut Simard, Frederic aut Caccone, Adalgisa aut Do Rosario, Virgilio E aut Pinto, João aut Benito, Agustín aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 15. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:15 month:10 https://dx.doi.org/10.1186/1475-2875-6-137 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 15 10
allfields_unstemmed	10.1186/1475-2875-6-137 doi (DE-627)SPR028600959 (SPR)1475-2875-6-137-e DE-627 ger DE-627 rakwb eng Moreno, Marta verfasserin aut Genetic population structure of Anopheles gambiae in Equatorial Guinea 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Moreno et al; licensee BioMed Central Ltd. 2007 Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213 Salgueiro, Patricia aut Vicente, José Luis aut Cano, Jorge aut Berzosa, Pedro J aut de Lucio, Aida aut Simard, Frederic aut Caccone, Adalgisa aut Do Rosario, Virgilio E aut Pinto, João aut Benito, Agustín aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 15. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:15 month:10 https://dx.doi.org/10.1186/1475-2875-6-137 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 15 10
allfieldsGer	10.1186/1475-2875-6-137 doi (DE-627)SPR028600959 (SPR)1475-2875-6-137-e DE-627 ger DE-627 rakwb eng Moreno, Marta verfasserin aut Genetic population structure of Anopheles gambiae in Equatorial Guinea 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Moreno et al; licensee BioMed Central Ltd. 2007 Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213 Salgueiro, Patricia aut Vicente, José Luis aut Cano, Jorge aut Berzosa, Pedro J aut de Lucio, Aida aut Simard, Frederic aut Caccone, Adalgisa aut Do Rosario, Virgilio E aut Pinto, João aut Benito, Agustín aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 15. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:15 month:10 https://dx.doi.org/10.1186/1475-2875-6-137 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 15 10
allfieldsSound	10.1186/1475-2875-6-137 doi (DE-627)SPR028600959 (SPR)1475-2875-6-137-e DE-627 ger DE-627 rakwb eng Moreno, Marta verfasserin aut Genetic population structure of Anopheles gambiae in Equatorial Guinea 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Moreno et al; licensee BioMed Central Ltd. 2007 Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213 Salgueiro, Patricia aut Vicente, José Luis aut Cano, Jorge aut Berzosa, Pedro J aut de Lucio, Aida aut Simard, Frederic aut Caccone, Adalgisa aut Do Rosario, Virgilio E aut Pinto, João aut Benito, Agustín aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 15. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:15 month:10 https://dx.doi.org/10.1186/1475-2875-6-137 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 15 10
language	English
source	Enthalten in Malaria journal 6(2007), 1 vom: 15. Okt. volume:6 year:2007 number:1 day:15 month:10
sourceStr	Enthalten in Malaria journal 6(2007), 1 vom: 15. Okt. volume:6 year:2007 number:1 day:15 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Malaria Genetic Differentiation Molecular Form Paracentric Inversion Promote Gene Flow
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Moreno, Marta @@aut@@ Salgueiro, Patricia @@aut@@ Vicente, José Luis @@aut@@ Cano, Jorge @@aut@@ Berzosa, Pedro J @@aut@@ de Lucio, Aida @@aut@@ Simard, Frederic @@aut@@ Caccone, Adalgisa @@aut@@ Do Rosario, Virgilio E @@aut@@ Pinto, João @@aut@@ Benito, Agustín @@aut@@
publishDateDaySort_date	2007-10-15T00:00:00Z
hierarchy_top_id	355986582
id	SPR028600959
language_de	englisch
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author	Moreno, Marta
spellingShingle	Moreno, Marta misc Malaria misc Genetic Differentiation misc Molecular Form misc Paracentric Inversion misc Promote Gene Flow Genetic population structure of Anopheles gambiae in Equatorial Guinea
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topic_title	Genetic population structure of Anopheles gambiae in Equatorial Guinea Malaria (dpeaa)DE-He213 Genetic Differentiation (dpeaa)DE-He213 Molecular Form (dpeaa)DE-He213 Paracentric Inversion (dpeaa)DE-He213 Promote Gene Flow (dpeaa)DE-He213
topic	misc Malaria misc Genetic Differentiation misc Molecular Form misc Paracentric Inversion misc Promote Gene Flow
topic_unstemmed	misc Malaria misc Genetic Differentiation misc Molecular Form misc Paracentric Inversion misc Promote Gene Flow
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title	Genetic population structure of Anopheles gambiae in Equatorial Guinea
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title_full	Genetic population structure of Anopheles gambiae in Equatorial Guinea
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author_browse	Moreno, Marta Salgueiro, Patricia Vicente, José Luis Cano, Jorge Berzosa, Pedro J de Lucio, Aida Simard, Frederic Caccone, Adalgisa Do Rosario, Virgilio E Pinto, João Benito, Agustín
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title_sort	genetic population structure of anopheles gambiae in equatorial guinea
title_auth	Genetic population structure of Anopheles gambiae in Equatorial Guinea
abstract	Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. © Moreno et al; licensee BioMed Central Ltd. 2007
abstractGer	Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. © Moreno et al; licensee BioMed Central Ltd. 2007
abstract_unstemmed	Background Patterns of genetic structure among mosquito vector populations in islands have received particular attention as these are considered potentially suitable sites for experimental trials on transgenic-based malaria control strategies. In this study, levels of genetic differentiation have been estimated between populations of Anopheles gambiae s.s. from the islands of Bioko and Annobón, and from continental Equatorial Guinea (EG) and Gabon. Methods Genotyping of 11 microsatellite loci located in chromosome 3 was performed in three island samples (two in Bioko and one in Annobón) and three mainland samples (two in EG and one in Gabon). Four samples belonged to the M molecular form and two to the S-form. Microsatellite data was used to estimate genetic diversity parameters, perform demographic equilibrium tests and analyse population differentiation. Results High levels of genetic differentiation were found between the more geographically remote island of Annobón and the continent, contrasting with the shallow differentiation between Bioko island, closest to mainland, and continental localities. In Bioko, differentiation between M and S forms was higher than that observed between island and mainland samples of the same molecular form. Conclusion The observed patterns of population structure seem to be governed by the presence of both physical (the ocean) and biological (the M-S form discontinuity) barriers to gene flow. The significant degree of genetic isolation between M and S forms detected by microsatellite loci located outside the "genomic islands" of speciation identified in A. gambiae s.s. further supports the hypothesis of on-going incipient speciation within this species. The implications of these findings regarding vector control strategies are discussed. © Moreno et al; licensee BioMed Central Ltd. 2007
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title_short	Genetic population structure of Anopheles gambiae in Equatorial Guinea
url	https://dx.doi.org/10.1186/1475-2875-6-137
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author2	Salgueiro, Patricia Vicente, José Luis Cano, Jorge Berzosa, Pedro J de Lucio, Aida Simard, Frederic Caccone, Adalgisa Do Rosario, Virgilio E Pinto, João Benito, Agustín
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Genetic population structure of Anopheles gambiae in Equatorial Guinea

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