The effect of HIV on morbidity and mortality in children with severe malarial anaemia

Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusio...
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Autor*in:	Malamba, Samuel [verfasserIn] Hladik, Wolfgang Reingold, Arthur Banage, Flora McFarland, Willi Rutherford, George Mimbe, Derrick Nzaro, Esau Downing, Robert Mermin, Jonathan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Human Immunodeficiency Virus Malaria Human Immunodeficiency Virus Infection Artesunate Incidence Rate Ratio

Anmerkung:	© Malamba et al; licensee BioMed Central Ltd. 2007

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 6(2007), 1 vom: 31. Okt.
Übergeordnetes Werk:	volume:6 ; year:2007 ; number:1 ; day:31 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1475-2875-6-143

Katalog-ID:	SPR028601025

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100	1		\|a Malamba, Samuel \|e verfasserin \|4 aut
245	1	4	\|a The effect of HIV on morbidity and mortality in children with severe malarial anaemia
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520			\|a Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy.
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700	1		\|a Hladik, Wolfgang \|4 aut
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700	1		\|a Banage, Flora \|4 aut
700	1		\|a McFarland, Willi \|4 aut
700	1		\|a Rutherford, George \|4 aut
700	1		\|a Mimbe, Derrick \|4 aut
700	1		\|a Nzaro, Esau \|4 aut
700	1		\|a Downing, Robert \|4 aut
700	1		\|a Mermin, Jonathan \|4 aut
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publishDate	2007
allfields	10.1186/1475-2875-6-143 doi (DE-627)SPR028601025 (SPR)1475-2875-6-143-e DE-627 ger DE-627 rakwb eng Malamba, Samuel verfasserin aut The effect of HIV on morbidity and mortality in children with severe malarial anaemia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Malamba et al; licensee BioMed Central Ltd. 2007 Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213 Hladik, Wolfgang aut Reingold, Arthur aut Banage, Flora aut McFarland, Willi aut Rutherford, George aut Mimbe, Derrick aut Nzaro, Esau aut Downing, Robert aut Mermin, Jonathan aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 31. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:31 month:10 https://dx.doi.org/10.1186/1475-2875-6-143 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 31 10
spelling	10.1186/1475-2875-6-143 doi (DE-627)SPR028601025 (SPR)1475-2875-6-143-e DE-627 ger DE-627 rakwb eng Malamba, Samuel verfasserin aut The effect of HIV on morbidity and mortality in children with severe malarial anaemia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Malamba et al; licensee BioMed Central Ltd. 2007 Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213 Hladik, Wolfgang aut Reingold, Arthur aut Banage, Flora aut McFarland, Willi aut Rutherford, George aut Mimbe, Derrick aut Nzaro, Esau aut Downing, Robert aut Mermin, Jonathan aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 31. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:31 month:10 https://dx.doi.org/10.1186/1475-2875-6-143 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 31 10
allfields_unstemmed	10.1186/1475-2875-6-143 doi (DE-627)SPR028601025 (SPR)1475-2875-6-143-e DE-627 ger DE-627 rakwb eng Malamba, Samuel verfasserin aut The effect of HIV on morbidity and mortality in children with severe malarial anaemia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Malamba et al; licensee BioMed Central Ltd. 2007 Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213 Hladik, Wolfgang aut Reingold, Arthur aut Banage, Flora aut McFarland, Willi aut Rutherford, George aut Mimbe, Derrick aut Nzaro, Esau aut Downing, Robert aut Mermin, Jonathan aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 31. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:31 month:10 https://dx.doi.org/10.1186/1475-2875-6-143 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 31 10
allfieldsGer	10.1186/1475-2875-6-143 doi (DE-627)SPR028601025 (SPR)1475-2875-6-143-e DE-627 ger DE-627 rakwb eng Malamba, Samuel verfasserin aut The effect of HIV on morbidity and mortality in children with severe malarial anaemia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Malamba et al; licensee BioMed Central Ltd. 2007 Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213 Hladik, Wolfgang aut Reingold, Arthur aut Banage, Flora aut McFarland, Willi aut Rutherford, George aut Mimbe, Derrick aut Nzaro, Esau aut Downing, Robert aut Mermin, Jonathan aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 31. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:31 month:10 https://dx.doi.org/10.1186/1475-2875-6-143 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 31 10
allfieldsSound	10.1186/1475-2875-6-143 doi (DE-627)SPR028601025 (SPR)1475-2875-6-143-e DE-627 ger DE-627 rakwb eng Malamba, Samuel verfasserin aut The effect of HIV on morbidity and mortality in children with severe malarial anaemia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Malamba et al; licensee BioMed Central Ltd. 2007 Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213 Hladik, Wolfgang aut Reingold, Arthur aut Banage, Flora aut McFarland, Willi aut Rutherford, George aut Mimbe, Derrick aut Nzaro, Esau aut Downing, Robert aut Mermin, Jonathan aut Enthalten in Malaria journal London : BioMed Central, 2002 6(2007), 1 vom: 31. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:6 year:2007 number:1 day:31 month:10 https://dx.doi.org/10.1186/1475-2875-6-143 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 31 10
language	English
source	Enthalten in Malaria journal 6(2007), 1 vom: 31. Okt. volume:6 year:2007 number:1 day:31 month:10
sourceStr	Enthalten in Malaria journal 6(2007), 1 vom: 31. Okt. volume:6 year:2007 number:1 day:31 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Human Immunodeficiency Virus Malaria Human Immunodeficiency Virus Infection Artesunate Incidence Rate Ratio
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Malamba, Samuel @@aut@@ Hladik, Wolfgang @@aut@@ Reingold, Arthur @@aut@@ Banage, Flora @@aut@@ McFarland, Willi @@aut@@ Rutherford, George @@aut@@ Mimbe, Derrick @@aut@@ Nzaro, Esau @@aut@@ Downing, Robert @@aut@@ Mermin, Jonathan @@aut@@
publishDateDaySort_date	2007-10-31T00:00:00Z
hierarchy_top_id	355986582
id	SPR028601025
language_de	englisch
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The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. 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author	Malamba, Samuel
spellingShingle	Malamba, Samuel misc Human Immunodeficiency Virus misc Malaria misc Human Immunodeficiency Virus Infection misc Artesunate misc Incidence Rate Ratio The effect of HIV on morbidity and mortality in children with severe malarial anaemia
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topic_title	The effect of HIV on morbidity and mortality in children with severe malarial anaemia Human Immunodeficiency Virus (dpeaa)DE-He213 Malaria (dpeaa)DE-He213 Human Immunodeficiency Virus Infection (dpeaa)DE-He213 Artesunate (dpeaa)DE-He213 Incidence Rate Ratio (dpeaa)DE-He213
topic	misc Human Immunodeficiency Virus misc Malaria misc Human Immunodeficiency Virus Infection misc Artesunate misc Incidence Rate Ratio
topic_unstemmed	misc Human Immunodeficiency Virus misc Malaria misc Human Immunodeficiency Virus Infection misc Artesunate misc Incidence Rate Ratio
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title	The effect of HIV on morbidity and mortality in children with severe malarial anaemia
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title_full	The effect of HIV on morbidity and mortality in children with severe malarial anaemia
author_sort	Malamba, Samuel
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author_browse	Malamba, Samuel Hladik, Wolfgang Reingold, Arthur Banage, Flora McFarland, Willi Rutherford, George Mimbe, Derrick Nzaro, Esau Downing, Robert Mermin, Jonathan
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author-letter	Malamba, Samuel
doi_str_mv	10.1186/1475-2875-6-143
title_sort	effect of hiv on morbidity and mortality in children with severe malarial anaemia
title_auth	The effect of HIV on morbidity and mortality in children with severe malarial anaemia
abstract	Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. © Malamba et al; licensee BioMed Central Ltd. 2007
abstractGer	Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. © Malamba et al; licensee BioMed Central Ltd. 2007
abstract_unstemmed	Background Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed. Methods Children <5 years old were followed as part of a prospective cohort study to assess the transfusion-associated transmission of blood-borne pathogens at Mulago Hospital, Kampala, Uganda. All children were hospitalized with a diagnosis of severe malarial anaemia requiring blood transfusion. Survival to different time points post-transfusion was compared between HIV-infected and uninfected children. Generalized estimating equations were used to analyse repeated measurement outcomes of morbidity, adjusting for confounders. Findings Of 847 children, 78 (9.2%) were HIV-infected. Median follow-up time was 162 days (inter-quartile range: 111, 169). HIV-infected children were more likely to die within 7 days (Hazard ratio [HR] = 2.86, 95% Confidence interval [CI] 1.30–6.29, P = 0.009) and within 28 days (HR = 3.70, 95% CI 1.91–7.17, P < 0.001) of an episode of severe malarial anaemia, and were more likely to die in the 6 months post-transfusion (HR = 5.70, 95% CI 3.54–9.16, P < 0.001) compared to HIV-uninfected children. HIV-infected children had more frequent re-admissions due to malaria within 28 days (Incidence rate ratio (IRR) = 3.74, 95% CI 1.41–9.90, P = 0.008) and within 6 months (IRR = 2.66, 95% CI 1.17 – 6.07, P = 0.02) post-transfusion than HIV-uninfected children. Conclusion HIV-infected children with severe malarial anaemia suffered higher all-cause mortality and malaria-related mortality than HIV-uninfected children. Children with HIV and malaria should receive aggressive treatment and further evaluation of their HIV disease, particularly with regard to cotrimoxazole prophylaxis and antiretroviral therapy. © Malamba et al; licensee BioMed Central Ltd. 2007
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title_short	The effect of HIV on morbidity and mortality in children with severe malarial anaemia
url	https://dx.doi.org/10.1186/1475-2875-6-143
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author2	Hladik, Wolfgang Reingold, Arthur Banage, Flora McFarland, Willi Rutherford, George Mimbe, Derrick Nzaro, Esau Downing, Robert Mermin, Jonathan
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The effect of HIV on morbidity and mortality in children with severe malarial anaemia

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