Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis

Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a...
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Autor*in:	Mwaniki, Michael K [verfasserIn] Talbert, Alison W Mturi, Florence N Berkley, James A Kager, Piet Marsh, Kevin Newton, Charles R

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Malaria Cerebral Malaria Parasite Density Entomological Inoculation Rate Demographic Surveillance System

Anmerkung:	© Mwaniki et al; licensee BioMed Central Ltd. 2010

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 9(2010), 1 vom: 06. Nov.
Übergeordnetes Werk:	volume:9 ; year:2010 ; number:1 ; day:06 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1475-2875-9-313

Katalog-ID:	SPR028611543

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245	1	0	\|a Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
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520			\|a Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region.
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700	1		\|a Talbert, Alison W \|4 aut
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700	1		\|a Berkley, James A \|4 aut
700	1		\|a Kager, Piet \|4 aut
700	1		\|a Marsh, Kevin \|4 aut
700	1		\|a Newton, Charles R \|4 aut
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allfields	10.1186/1475-2875-9-313 doi (DE-627)SPR028611543 (SPR)1475-2875-9-313-e DE-627 ger DE-627 rakwb eng Mwaniki, Michael K verfasserin aut Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mwaniki et al; licensee BioMed Central Ltd. 2010 Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213 Talbert, Alison W aut Mturi, Florence N aut Berkley, James A aut Kager, Piet aut Marsh, Kevin aut Newton, Charles R aut Enthalten in Malaria journal London : BioMed Central, 2002 9(2010), 1 vom: 06. Nov. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:9 year:2010 number:1 day:06 month:11 https://dx.doi.org/10.1186/1475-2875-9-313 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2010 1 06 11
spelling	10.1186/1475-2875-9-313 doi (DE-627)SPR028611543 (SPR)1475-2875-9-313-e DE-627 ger DE-627 rakwb eng Mwaniki, Michael K verfasserin aut Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mwaniki et al; licensee BioMed Central Ltd. 2010 Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213 Talbert, Alison W aut Mturi, Florence N aut Berkley, James A aut Kager, Piet aut Marsh, Kevin aut Newton, Charles R aut Enthalten in Malaria journal London : BioMed Central, 2002 9(2010), 1 vom: 06. Nov. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:9 year:2010 number:1 day:06 month:11 https://dx.doi.org/10.1186/1475-2875-9-313 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2010 1 06 11
allfields_unstemmed	10.1186/1475-2875-9-313 doi (DE-627)SPR028611543 (SPR)1475-2875-9-313-e DE-627 ger DE-627 rakwb eng Mwaniki, Michael K verfasserin aut Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mwaniki et al; licensee BioMed Central Ltd. 2010 Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213 Talbert, Alison W aut Mturi, Florence N aut Berkley, James A aut Kager, Piet aut Marsh, Kevin aut Newton, Charles R aut Enthalten in Malaria journal London : BioMed Central, 2002 9(2010), 1 vom: 06. Nov. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:9 year:2010 number:1 day:06 month:11 https://dx.doi.org/10.1186/1475-2875-9-313 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2010 1 06 11
allfieldsGer	10.1186/1475-2875-9-313 doi (DE-627)SPR028611543 (SPR)1475-2875-9-313-e DE-627 ger DE-627 rakwb eng Mwaniki, Michael K verfasserin aut Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mwaniki et al; licensee BioMed Central Ltd. 2010 Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213 Talbert, Alison W aut Mturi, Florence N aut Berkley, James A aut Kager, Piet aut Marsh, Kevin aut Newton, Charles R aut Enthalten in Malaria journal London : BioMed Central, 2002 9(2010), 1 vom: 06. Nov. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:9 year:2010 number:1 day:06 month:11 https://dx.doi.org/10.1186/1475-2875-9-313 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2010 1 06 11
allfieldsSound	10.1186/1475-2875-9-313 doi (DE-627)SPR028611543 (SPR)1475-2875-9-313-e DE-627 ger DE-627 rakwb eng Mwaniki, Michael K verfasserin aut Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mwaniki et al; licensee BioMed Central Ltd. 2010 Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213 Talbert, Alison W aut Mturi, Florence N aut Berkley, James A aut Kager, Piet aut Marsh, Kevin aut Newton, Charles R aut Enthalten in Malaria journal London : BioMed Central, 2002 9(2010), 1 vom: 06. Nov. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:9 year:2010 number:1 day:06 month:11 https://dx.doi.org/10.1186/1475-2875-9-313 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2010 1 06 11
language	English
source	Enthalten in Malaria journal 9(2010), 1 vom: 06. Nov. volume:9 year:2010 number:1 day:06 month:11
sourceStr	Enthalten in Malaria journal 9(2010), 1 vom: 06. Nov. volume:9 year:2010 number:1 day:06 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Malaria Cerebral Malaria Parasite Density Entomological Inoculation Rate Demographic Surveillance System
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Mwaniki, Michael K @@aut@@ Talbert, Alison W @@aut@@ Mturi, Florence N @@aut@@ Berkley, James A @@aut@@ Kager, Piet @@aut@@ Marsh, Kevin @@aut@@ Newton, Charles R @@aut@@
publishDateDaySort_date	2010-11-06T00:00:00Z
hierarchy_top_id	355986582
id	SPR028611543
language_de	englisch
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However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. 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author	Mwaniki, Michael K
spellingShingle	Mwaniki, Michael K misc Malaria misc Cerebral Malaria misc Parasite Density misc Entomological Inoculation Rate misc Demographic Surveillance System Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
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topic_title	Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis Malaria (dpeaa)DE-He213 Cerebral Malaria (dpeaa)DE-He213 Parasite Density (dpeaa)DE-He213 Entomological Inoculation Rate (dpeaa)DE-He213 Demographic Surveillance System (dpeaa)DE-He213
topic	misc Malaria misc Cerebral Malaria misc Parasite Density misc Entomological Inoculation Rate misc Demographic Surveillance System
topic_unstemmed	misc Malaria misc Cerebral Malaria misc Parasite Density misc Entomological Inoculation Rate misc Demographic Surveillance System
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title	Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
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title_full	Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
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author_browse	Mwaniki, Michael K Talbert, Alison W Mturi, Florence N Berkley, James A Kager, Piet Marsh, Kevin Newton, Charles R
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title_sort	congenital and neonatal malaria in a rural kenyan district hospital: an eight-year analysis
title_auth	Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
abstract	Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. © Mwaniki et al; licensee BioMed Central Ltd. 2010
abstractGer	Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. © Mwaniki et al; licensee BioMed Central Ltd. 2010
abstract_unstemmed	Background Malaria remains a significant burden in sub-Saharan Africa. However, data on burden of congenital and neonatal malaria is scarce and contradictory, with some recent studies reporting a high burden. Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described. Methods From $ 1^{st} $ January 2002 to $ 31^{st} $ December 2009, admission and discharge information on all neonates admitted to Kilifi District Hospital was collected. At admission, blood was also drawn for routine investigations, which included a full blood count, blood culture and blood slide for malaria parasites. Results Of the 5,114 neonates admitted during the eight-year surveillance period, blood slide for malaria parasites was performed in 4,790 (93.7%). 18 (0.35%) neonates with Plasmodium falciparum malaria parasitaemia, of whom 11 were admitted within the first week of life and thus classified as congenital parasitaemia, were identified. 7/18 (39%) had fever. Parasite densities were low, ≤50 per μl in 14 cases. The presence of parasitaemia was associated with low haemoglobin (Hb) of <10 g/dl ($ χ^{2} $ 10.9 P = 0.001). The case fatality rate of those with and without parasitaemia was similar. Plasmodium falciparum parasitaemia was identified as the cause of symptoms in four neonates. Conclusion Congenital and neonatal malaria are rare in this malaria endemic region. Performing a blood slide for malaria parasites among sick neonates in malaria endemic regions is advisable. This study does not support routine treatment with anti-malarial drugs among admitted neonates with or without fever even in a malaria endemic region. © Mwaniki et al; licensee BioMed Central Ltd. 2010
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title_short	Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis
url	https://dx.doi.org/10.1186/1475-2875-9-313
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author2	Talbert, Alison W Mturi, Florence N Berkley, James A Kager, Piet Marsh, Kevin Newton, Charles R
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Congenital and neonatal malaria in a rural Kenyan district hospital: An eight-year analysis

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