Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators...
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Autor*in:	Pappa, Vasiliki [verfasserIn] Seydel, Karl Gupta, Sanchit Feintuch, Catherine M. Potchen, Michael J. Kampondeni, Samuel Goldman-Yassen, Adam Veenstra, Mike Lopez, Lillie Kim, Ryung S. Berman, Joan W. Taylor, Terrie Daily, Johanna P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Cerebral malaria Brain swelling Inflammation Phospholipase A Plasma small molecules Cytokines

Anmerkung:	© Pappa et al. 2015

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 14(2015), 1 vom: 21. Dez.
Übergeordnetes Werk:	volume:14 ; year:2015 ; number:1 ; day:21 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s12936-015-1036-1

Katalog-ID:	SPR028637895

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245	1	0	\|a Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
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520			\|a Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM.
650		4	\|a Cerebral malaria \|7 (dpeaa)DE-He213
650		4	\|a Brain swelling \|7 (dpeaa)DE-He213
650		4	\|a Inflammation \|7 (dpeaa)DE-He213
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650		4	\|a Cytokines \|7 (dpeaa)DE-He213
700	1		\|a Seydel, Karl \|4 aut
700	1		\|a Gupta, Sanchit \|4 aut
700	1		\|a Feintuch, Catherine M. \|4 aut
700	1		\|a Potchen, Michael J. \|4 aut
700	1		\|a Kampondeni, Samuel \|4 aut
700	1		\|a Goldman-Yassen, Adam \|4 aut
700	1		\|a Veenstra, Mike \|4 aut
700	1		\|a Lopez, Lillie \|4 aut
700	1		\|a Kim, Ryung S. \|4 aut
700	1		\|a Berman, Joan W. \|4 aut
700	1		\|a Taylor, Terrie \|4 aut
700	1		\|a Daily, Johanna P. \|4 aut
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allfields	10.1186/s12936-015-1036-1 doi (DE-627)SPR028637895 (SPR)s12936-015-1036-1-e DE-627 ger DE-627 rakwb eng Pappa, Vasiliki verfasserin aut Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pappa et al. 2015 Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Seydel, Karl aut Gupta, Sanchit aut Feintuch, Catherine M. aut Potchen, Michael J. aut Kampondeni, Samuel aut Goldman-Yassen, Adam aut Veenstra, Mike aut Lopez, Lillie aut Kim, Ryung S. aut Berman, Joan W. aut Taylor, Terrie aut Daily, Johanna P. aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 21. Dez. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:21 month:12 https://dx.doi.org/10.1186/s12936-015-1036-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 21 12
spelling	10.1186/s12936-015-1036-1 doi (DE-627)SPR028637895 (SPR)s12936-015-1036-1-e DE-627 ger DE-627 rakwb eng Pappa, Vasiliki verfasserin aut Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pappa et al. 2015 Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Seydel, Karl aut Gupta, Sanchit aut Feintuch, Catherine M. aut Potchen, Michael J. aut Kampondeni, Samuel aut Goldman-Yassen, Adam aut Veenstra, Mike aut Lopez, Lillie aut Kim, Ryung S. aut Berman, Joan W. aut Taylor, Terrie aut Daily, Johanna P. aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 21. Dez. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:21 month:12 https://dx.doi.org/10.1186/s12936-015-1036-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 21 12
allfields_unstemmed	10.1186/s12936-015-1036-1 doi (DE-627)SPR028637895 (SPR)s12936-015-1036-1-e DE-627 ger DE-627 rakwb eng Pappa, Vasiliki verfasserin aut Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pappa et al. 2015 Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Seydel, Karl aut Gupta, Sanchit aut Feintuch, Catherine M. aut Potchen, Michael J. aut Kampondeni, Samuel aut Goldman-Yassen, Adam aut Veenstra, Mike aut Lopez, Lillie aut Kim, Ryung S. aut Berman, Joan W. aut Taylor, Terrie aut Daily, Johanna P. aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 21. Dez. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:21 month:12 https://dx.doi.org/10.1186/s12936-015-1036-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 21 12
allfieldsGer	10.1186/s12936-015-1036-1 doi (DE-627)SPR028637895 (SPR)s12936-015-1036-1-e DE-627 ger DE-627 rakwb eng Pappa, Vasiliki verfasserin aut Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pappa et al. 2015 Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Seydel, Karl aut Gupta, Sanchit aut Feintuch, Catherine M. aut Potchen, Michael J. aut Kampondeni, Samuel aut Goldman-Yassen, Adam aut Veenstra, Mike aut Lopez, Lillie aut Kim, Ryung S. aut Berman, Joan W. aut Taylor, Terrie aut Daily, Johanna P. aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 21. Dez. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:21 month:12 https://dx.doi.org/10.1186/s12936-015-1036-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 21 12
allfieldsSound	10.1186/s12936-015-1036-1 doi (DE-627)SPR028637895 (SPR)s12936-015-1036-1-e DE-627 ger DE-627 rakwb eng Pappa, Vasiliki verfasserin aut Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pappa et al. 2015 Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Seydel, Karl aut Gupta, Sanchit aut Feintuch, Catherine M. aut Potchen, Michael J. aut Kampondeni, Samuel aut Goldman-Yassen, Adam aut Veenstra, Mike aut Lopez, Lillie aut Kim, Ryung S. aut Berman, Joan W. aut Taylor, Terrie aut Daily, Johanna P. aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 21. Dez. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:21 month:12 https://dx.doi.org/10.1186/s12936-015-1036-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 21 12
language	English
source	Enthalten in Malaria journal 14(2015), 1 vom: 21. Dez. volume:14 year:2015 number:1 day:21 month:12
sourceStr	Enthalten in Malaria journal 14(2015), 1 vom: 21. Dez. volume:14 year:2015 number:1 day:21 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cerebral malaria Brain swelling Inflammation Phospholipase A Plasma small molecules Cytokines
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Pappa, Vasiliki @@aut@@ Seydel, Karl @@aut@@ Gupta, Sanchit @@aut@@ Feintuch, Catherine M. @@aut@@ Potchen, Michael J. @@aut@@ Kampondeni, Samuel @@aut@@ Goldman-Yassen, Adam @@aut@@ Veenstra, Mike @@aut@@ Lopez, Lillie @@aut@@ Kim, Ryung S. @@aut@@ Berman, Joan W. @@aut@@ Taylor, Terrie @@aut@@ Daily, Johanna P. @@aut@@
publishDateDaySort_date	2015-12-21T00:00:00Z
hierarchy_top_id	355986582
id	SPR028637895
language_de	englisch
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CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. 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author	Pappa, Vasiliki
spellingShingle	Pappa, Vasiliki misc Cerebral malaria misc Brain swelling misc Inflammation misc Phospholipase A misc Plasma small molecules misc Cytokines Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
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topic_title	Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria Cerebral malaria (dpeaa)DE-He213 Brain swelling (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Phospholipase A (dpeaa)DE-He213 Plasma small molecules (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213
topic	misc Cerebral malaria misc Brain swelling misc Inflammation misc Phospholipase A misc Plasma small molecules misc Cytokines
topic_unstemmed	misc Cerebral malaria misc Brain swelling misc Inflammation misc Phospholipase A misc Plasma small molecules misc Cytokines
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title	Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
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title_full	Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
author_sort	Pappa, Vasiliki
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author_browse	Pappa, Vasiliki Seydel, Karl Gupta, Sanchit Feintuch, Catherine M. Potchen, Michael J. Kampondeni, Samuel Goldman-Yassen, Adam Veenstra, Mike Lopez, Lillie Kim, Ryung S. Berman, Joan W. Taylor, Terrie Daily, Johanna P.
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doi_str_mv	10.1186/s12936-015-1036-1
title_sort	lipid metabolites of the phospholipase $ a_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
title_auth	Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
abstract	Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. © Pappa et al. 2015
abstractGer	Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. © Pappa et al. 2015
abstract_unstemmed	Background Cerebral malaria (CM) remains a significant cause of morbidity and mortality in children in sub-Saharan Africa. CM mortality has been associated with increased brain volume, seen on neuroimaging studies. Methods To examine the potential role of blood metabolites and inflammatory mediators in increased brain volume in Malawian children with CM, an association study was performed between plasma metabolites, cytokine levels and phospholipase $ A_{2} $ ($ PLA_{2} $) activity with brain volume. Results The metabolomics analysis demonstrated arachidonic acid and other lysophospholipids to be positively associated with brain swelling. These lipids are products of the $ PLA_{2} $ enzyme and an association of plasma $ PLA_{2} $ enzymatic activity with brain swelling was confirmed. TNFα, which can upregulate $ PLA_{2} $ activity, was associated with brain volume. In addition, CCL2 and IL-8 were also associated with brain volume. Some of these cytokines can alter endothelial cell tight junction proteins and increase blood brain barrier permeability. Conclusions Taken together, paediatric CM brain volume was associated with products of the $ PLA_{2} $ pathway and inflammatory cytokines. Their role in causality is unknown. These molecules will need to undergo testing in vitro and in animal models to understand their role in processes of increased brain volume. These observations provide novel data on host physiology associated with paediatric CM brain swelling, and may both inform pathogenesis models and suggest adjunct therapies that could improve the morbidity and mortality associated with paediatric CM. © Pappa et al. 2015
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title_short	Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria
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author2	Seydel, Karl Gupta, Sanchit Feintuch, Catherine M. Potchen, Michael J. Kampondeni, Samuel Goldman-Yassen, Adam Veenstra, Mike Lopez, Lillie Kim, Ryung S. Berman, Joan W. Taylor, Terrie Daily, Johanna P.
author2Str	Seydel, Karl Gupta, Sanchit Feintuch, Catherine M. Potchen, Michael J. Kampondeni, Samuel Goldman-Yassen, Adam Veenstra, Mike Lopez, Lillie Kim, Ryung S. Berman, Joan W. Taylor, Terrie Daily, Johanna P.
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up_date	2024-07-03T20:44:05.633Z
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Lipid metabolites of the phospholipase $ A_{2} $ pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

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