The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi
Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Artimovich, Elena [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) |
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| Anmerkung: |
© Artimovich et al. 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Malaria journal - London : BioMed Central, 2002, 14(2015), 1 vom: 05. Okt. |
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| Übergeordnetes Werk: |
volume:14 ; year:2015 ; number:1 ; day:05 ; month:10 |
| Links: |
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| DOI / URN: |
10.1186/s12936-015-0860-7 |
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| Katalog-ID: |
SPR028641914 |
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| 100 | 1 | |a Artimovich, Elena |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi |
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| 520 | |a Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. | ||
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| 650 | 4 | |a Sulfadoxine–pyrimethamine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Resistance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Selective sweeps |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kapito-Tembo, Atupele |4 aut | |
| 700 | 1 | |a Pensulo, Paul |4 aut | |
| 700 | 1 | |a Nyirenda, Osward |4 aut | |
| 700 | 1 | |a Brown, Sarah |4 aut | |
| 700 | 1 | |a Joshi, Sudhaunshu |4 aut | |
| 700 | 1 | |a Taylor, Terrie E. |4 aut | |
| 700 | 1 | |a Mathanga, Don |4 aut | |
| 700 | 1 | |a Escalante, Ananias A. |4 aut | |
| 700 | 1 | |a Laufer, Miriam K. |4 aut | |
| 700 | 1 | |a Takala-Harrison, Shannon |4 aut | |
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10.1186/s12936-015-0860-7 doi (DE-627)SPR028641914 (SPR)s12936-015-0860-7-e DE-627 ger DE-627 rakwb eng Artimovich, Elena verfasserin aut The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Artimovich et al. 2015 Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 Kapito-Tembo, Atupele aut Pensulo, Paul aut Nyirenda, Osward aut Brown, Sarah aut Joshi, Sudhaunshu aut Taylor, Terrie E. aut Mathanga, Don aut Escalante, Ananias A. aut Laufer, Miriam K. aut Takala-Harrison, Shannon aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 05. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:05 month:10 https://dx.doi.org/10.1186/s12936-015-0860-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 05 10 |
| spelling |
10.1186/s12936-015-0860-7 doi (DE-627)SPR028641914 (SPR)s12936-015-0860-7-e DE-627 ger DE-627 rakwb eng Artimovich, Elena verfasserin aut The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Artimovich et al. 2015 Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 Kapito-Tembo, Atupele aut Pensulo, Paul aut Nyirenda, Osward aut Brown, Sarah aut Joshi, Sudhaunshu aut Taylor, Terrie E. aut Mathanga, Don aut Escalante, Ananias A. aut Laufer, Miriam K. aut Takala-Harrison, Shannon aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 05. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:05 month:10 https://dx.doi.org/10.1186/s12936-015-0860-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 05 10 |
| allfields_unstemmed |
10.1186/s12936-015-0860-7 doi (DE-627)SPR028641914 (SPR)s12936-015-0860-7-e DE-627 ger DE-627 rakwb eng Artimovich, Elena verfasserin aut The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Artimovich et al. 2015 Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 Kapito-Tembo, Atupele aut Pensulo, Paul aut Nyirenda, Osward aut Brown, Sarah aut Joshi, Sudhaunshu aut Taylor, Terrie E. aut Mathanga, Don aut Escalante, Ananias A. aut Laufer, Miriam K. aut Takala-Harrison, Shannon aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 05. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:05 month:10 https://dx.doi.org/10.1186/s12936-015-0860-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 05 10 |
| allfieldsGer |
10.1186/s12936-015-0860-7 doi (DE-627)SPR028641914 (SPR)s12936-015-0860-7-e DE-627 ger DE-627 rakwb eng Artimovich, Elena verfasserin aut The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Artimovich et al. 2015 Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 Kapito-Tembo, Atupele aut Pensulo, Paul aut Nyirenda, Osward aut Brown, Sarah aut Joshi, Sudhaunshu aut Taylor, Terrie E. aut Mathanga, Don aut Escalante, Ananias A. aut Laufer, Miriam K. aut Takala-Harrison, Shannon aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 05. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:05 month:10 https://dx.doi.org/10.1186/s12936-015-0860-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 05 10 |
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10.1186/s12936-015-0860-7 doi (DE-627)SPR028641914 (SPR)s12936-015-0860-7-e DE-627 ger DE-627 rakwb eng Artimovich, Elena verfasserin aut The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Artimovich et al. 2015 Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 Kapito-Tembo, Atupele aut Pensulo, Paul aut Nyirenda, Osward aut Brown, Sarah aut Joshi, Sudhaunshu aut Taylor, Terrie E. aut Mathanga, Don aut Escalante, Ananias A. aut Laufer, Miriam K. aut Takala-Harrison, Shannon aut Enthalten in Malaria journal London : BioMed Central, 2002 14(2015), 1 vom: 05. Okt. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:14 year:2015 number:1 day:05 month:10 https://dx.doi.org/10.1186/s12936-015-0860-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2015 1 05 10 |
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Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. 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The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi Malaria (dpeaa)DE-He213 Sulfadoxine–pyrimethamine (dpeaa)DE-He213 Resistance (dpeaa)DE-He213 Selective sweeps (dpeaa)DE-He213 Dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) (dpeaa)DE-He213 |
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The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi |
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The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi |
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Artimovich, Elena |
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Artimovich, Elena Kapito-Tembo, Atupele Pensulo, Paul Nyirenda, Osward Brown, Sarah Joshi, Sudhaunshu Taylor, Terrie E. Mathanga, Don Escalante, Ananias A. Laufer, Miriam K. Takala-Harrison, Shannon |
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effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in malawi |
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The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi |
| abstract |
Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. © Artimovich et al. 2015 |
| abstractGer |
Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. © Artimovich et al. 2015 |
| abstract_unstemmed |
Background Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater genetic diversity and more frequent genetic recombination, which could lead to a more rapid re-emergence of SP-sensitive parasites, as well as more rapid degradation of selective sweeps. In this study, the impact of local variation in malaria transmission on the prevalence of SP-resistant haplotypes and selective sweep characteristics was investigated at an urban site with low parasite prevalence and two rural sites with moderate and high parasite prevalence. Methods Samples from three sites with different parasite prevalence were genotyped for resistance markers within pfdhfr-ts and pfdhps and at microsatellites flanking these genes. Expected heterozygosity ($ H_{e} $) was estimated to evaluate genetic diversity. Results No difference in the prevalence of highly resistant DHFR 51I/59R/108N and DHPS 437G/540E was found between sites. Small differences in $ H_{e} $ flanking pfdhfr-ts and pfdhps were seen between rural-moderate and the other sites, as well as some shared haplotypes between the rural-high and urban-low sites. Conclusions The results do not show an effect of local variation in malaria transmission, as inferred from parasite prevalence, on SP-resistant haplotype prevalence. © Artimovich et al. 2015 |
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Kapito-Tembo, Atupele Pensulo, Paul Nyirenda, Osward Brown, Sarah Joshi, Sudhaunshu Taylor, Terrie E. Mathanga, Don Escalante, Ananias A. Laufer, Miriam K. Takala-Harrison, Shannon |
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