Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functi...
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Autor*in:	Duffy, Michael F. [verfasserIn] Noviyanti, Rintis Tsuboi, Takafumi Feng, Zhi-Ping Trianty, Leily Sebayang, Boni F. Takashima, Eizo Sumardy, Fransisca Lampah, Daniel A. Turner, Louise Lavstsen, Thomas Fowkes, Freya J. I. Siba, Peter Rogerson, Stephen J. Theander, Thor G. Marfurt, Jutta Price, Ric N. Anstey, Nicholas M. Brown, Graham V. Papenfuss, Anthony T.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Severe malaria genes PfEMP1

Anmerkung:	© Duffy et al. 2016

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 15(2016), 1 vom: 05. Mai
Übergeordnetes Werk:	volume:15 ; year:2016 ; number:1 ; day:05 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12936-016-1296-4

Katalog-ID:	SPR028646150

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520			\|a Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia.
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700	1		\|a Trianty, Leily \|4 aut
700	1		\|a Sebayang, Boni F. \|4 aut
700	1		\|a Takashima, Eizo \|4 aut
700	1		\|a Sumardy, Fransisca \|4 aut
700	1		\|a Lampah, Daniel A. \|4 aut
700	1		\|a Turner, Louise \|4 aut
700	1		\|a Lavstsen, Thomas \|4 aut
700	1		\|a Fowkes, Freya J. I. \|4 aut
700	1		\|a Siba, Peter \|4 aut
700	1		\|a Rogerson, Stephen J. \|4 aut
700	1		\|a Theander, Thor G. \|4 aut
700	1		\|a Marfurt, Jutta \|4 aut
700	1		\|a Price, Ric N. \|4 aut
700	1		\|a Anstey, Nicholas M. \|4 aut
700	1		\|a Brown, Graham V. \|4 aut
700	1		\|a Papenfuss, Anthony T. \|4 aut
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912			\|a GBV_ILN_4325
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912			\|a GBV_ILN_4367
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Indexfelder

author_variant	m f d mf mfd r n rn t t tt z p f zpf l t lt b f s bf bfs e t et f s fs d a l da dal l t lt t l tl f j i f fji fjif p s ps s j r sj sjr t g t tg tgt j m jm r n p rn rnp n m a nm nma g v b gv gvb a t p at atp
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hierarchy_sort_str	2016
publishDate	2016
allfields	10.1186/s12936-016-1296-4 doi (DE-627)SPR028646150 (SPR)s12936-016-1296-4-e DE-627 ger DE-627 rakwb eng Duffy, Michael F. verfasserin aut Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Duffy et al. 2016 Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213 Noviyanti, Rintis aut Tsuboi, Takafumi aut Feng, Zhi-Ping aut Trianty, Leily aut Sebayang, Boni F. aut Takashima, Eizo aut Sumardy, Fransisca aut Lampah, Daniel A. aut Turner, Louise aut Lavstsen, Thomas aut Fowkes, Freya J. I. aut Siba, Peter aut Rogerson, Stephen J. aut Theander, Thor G. aut Marfurt, Jutta aut Price, Ric N. aut Anstey, Nicholas M. aut Brown, Graham V. aut Papenfuss, Anthony T. aut Enthalten in Malaria journal London : BioMed Central, 2002 15(2016), 1 vom: 05. Mai (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:15 year:2016 number:1 day:05 month:05 https://dx.doi.org/10.1186/s12936-016-1296-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2016 1 05 05
spelling	10.1186/s12936-016-1296-4 doi (DE-627)SPR028646150 (SPR)s12936-016-1296-4-e DE-627 ger DE-627 rakwb eng Duffy, Michael F. verfasserin aut Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Duffy et al. 2016 Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213 Noviyanti, Rintis aut Tsuboi, Takafumi aut Feng, Zhi-Ping aut Trianty, Leily aut Sebayang, Boni F. aut Takashima, Eizo aut Sumardy, Fransisca aut Lampah, Daniel A. aut Turner, Louise aut Lavstsen, Thomas aut Fowkes, Freya J. I. aut Siba, Peter aut Rogerson, Stephen J. aut Theander, Thor G. aut Marfurt, Jutta aut Price, Ric N. aut Anstey, Nicholas M. aut Brown, Graham V. aut Papenfuss, Anthony T. aut Enthalten in Malaria journal London : BioMed Central, 2002 15(2016), 1 vom: 05. Mai (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:15 year:2016 number:1 day:05 month:05 https://dx.doi.org/10.1186/s12936-016-1296-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2016 1 05 05
allfields_unstemmed	10.1186/s12936-016-1296-4 doi (DE-627)SPR028646150 (SPR)s12936-016-1296-4-e DE-627 ger DE-627 rakwb eng Duffy, Michael F. verfasserin aut Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Duffy et al. 2016 Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213 Noviyanti, Rintis aut Tsuboi, Takafumi aut Feng, Zhi-Ping aut Trianty, Leily aut Sebayang, Boni F. aut Takashima, Eizo aut Sumardy, Fransisca aut Lampah, Daniel A. aut Turner, Louise aut Lavstsen, Thomas aut Fowkes, Freya J. I. aut Siba, Peter aut Rogerson, Stephen J. aut Theander, Thor G. aut Marfurt, Jutta aut Price, Ric N. aut Anstey, Nicholas M. aut Brown, Graham V. aut Papenfuss, Anthony T. aut Enthalten in Malaria journal London : BioMed Central, 2002 15(2016), 1 vom: 05. Mai (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:15 year:2016 number:1 day:05 month:05 https://dx.doi.org/10.1186/s12936-016-1296-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2016 1 05 05
allfieldsGer	10.1186/s12936-016-1296-4 doi (DE-627)SPR028646150 (SPR)s12936-016-1296-4-e DE-627 ger DE-627 rakwb eng Duffy, Michael F. verfasserin aut Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Duffy et al. 2016 Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213 Noviyanti, Rintis aut Tsuboi, Takafumi aut Feng, Zhi-Ping aut Trianty, Leily aut Sebayang, Boni F. aut Takashima, Eizo aut Sumardy, Fransisca aut Lampah, Daniel A. aut Turner, Louise aut Lavstsen, Thomas aut Fowkes, Freya J. I. aut Siba, Peter aut Rogerson, Stephen J. aut Theander, Thor G. aut Marfurt, Jutta aut Price, Ric N. aut Anstey, Nicholas M. aut Brown, Graham V. aut Papenfuss, Anthony T. aut Enthalten in Malaria journal London : BioMed Central, 2002 15(2016), 1 vom: 05. Mai (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:15 year:2016 number:1 day:05 month:05 https://dx.doi.org/10.1186/s12936-016-1296-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2016 1 05 05
allfieldsSound	10.1186/s12936-016-1296-4 doi (DE-627)SPR028646150 (SPR)s12936-016-1296-4-e DE-627 ger DE-627 rakwb eng Duffy, Michael F. verfasserin aut Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Duffy et al. 2016 Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213 Noviyanti, Rintis aut Tsuboi, Takafumi aut Feng, Zhi-Ping aut Trianty, Leily aut Sebayang, Boni F. aut Takashima, Eizo aut Sumardy, Fransisca aut Lampah, Daniel A. aut Turner, Louise aut Lavstsen, Thomas aut Fowkes, Freya J. I. aut Siba, Peter aut Rogerson, Stephen J. aut Theander, Thor G. aut Marfurt, Jutta aut Price, Ric N. aut Anstey, Nicholas M. aut Brown, Graham V. aut Papenfuss, Anthony T. aut Enthalten in Malaria journal London : BioMed Central, 2002 15(2016), 1 vom: 05. Mai (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:15 year:2016 number:1 day:05 month:05 https://dx.doi.org/10.1186/s12936-016-1296-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2016 1 05 05
language	English
source	Enthalten in Malaria journal 15(2016), 1 vom: 05. Mai volume:15 year:2016 number:1 day:05 month:05
sourceStr	Enthalten in Malaria journal 15(2016), 1 vom: 05. Mai volume:15 year:2016 number:1 day:05 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Severe malaria genes PfEMP1
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Duffy, Michael F. @@aut@@ Noviyanti, Rintis @@aut@@ Tsuboi, Takafumi @@aut@@ Feng, Zhi-Ping @@aut@@ Trianty, Leily @@aut@@ Sebayang, Boni F. @@aut@@ Takashima, Eizo @@aut@@ Sumardy, Fransisca @@aut@@ Lampah, Daniel A. @@aut@@ Turner, Louise @@aut@@ Lavstsen, Thomas @@aut@@ Fowkes, Freya J. I. @@aut@@ Siba, Peter @@aut@@ Rogerson, Stephen J. @@aut@@ Theander, Thor G. @@aut@@ Marfurt, Jutta @@aut@@ Price, Ric N. @@aut@@ Anstey, Nicholas M. @@aut@@ Brown, Graham V. @@aut@@ Papenfuss, Anthony T. @@aut@@
publishDateDaySort_date	2016-05-05T00:00:00Z
hierarchy_top_id	355986582
id	SPR028646150
language_de	englisch
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PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. 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author	Duffy, Michael F.
spellingShingle	Duffy, Michael F. misc Severe malaria misc genes misc PfEMP1 Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
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topic_title	Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria Severe malaria (dpeaa)DE-He213 genes (dpeaa)DE-He213 PfEMP1 (dpeaa)DE-He213
topic	misc Severe malaria misc genes misc PfEMP1
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title	Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
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title_full	Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
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author_browse	Duffy, Michael F. Noviyanti, Rintis Tsuboi, Takafumi Feng, Zhi-Ping Trianty, Leily Sebayang, Boni F. Takashima, Eizo Sumardy, Fransisca Lampah, Daniel A. Turner, Louise Lavstsen, Thomas Fowkes, Freya J. I. Siba, Peter Rogerson, Stephen J. Theander, Thor G. Marfurt, Jutta Price, Ric N. Anstey, Nicholas M. Brown, Graham V. Papenfuss, Anthony T.
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title_sort	differences in pfemp1s recognized by antibodies from patients with uncomplicated or severe malaria
title_auth	Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
abstract	Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. © Duffy et al. 2016
abstractGer	Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. © Duffy et al. 2016
abstract_unstemmed	Background Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. Methods Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from laboratory isolates. Antibodies from Papuan patients to these parts of multiple PfEMP1 proteins were measured. Results Patients with uncomplicated malaria were more likely to have antibodies that recognized PfEMP1 of Group C type and recognized a broader repertoire of group A and B PfEMP1s than patients with severe malaria. Conclusion These data suggest that exposure to a broad range of group A and B PfEMP1s is associated with protection from severe disease in Papua, Indonesia. © Duffy et al. 2016
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title_short	Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria
url	https://dx.doi.org/10.1186/s12936-016-1296-4
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author2	Noviyanti, Rintis Tsuboi, Takafumi Feng, Zhi-Ping Trianty, Leily Sebayang, Boni F. Takashima, Eizo Sumardy, Fransisca Lampah, Daniel A. Turner, Louise Lavstsen, Thomas Fowkes, Freya J. I. Siba, Peter Rogerson, Stephen J. Theander, Thor G. Marfurt, Jutta Price, Ric N. Anstey, Nicholas M. Brown, Graham V. Papenfuss, Anthony T.
author2Str	Noviyanti, Rintis Tsuboi, Takafumi Feng, Zhi-Ping Trianty, Leily Sebayang, Boni F. Takashima, Eizo Sumardy, Fransisca Lampah, Daniel A. Turner, Louise Lavstsen, Thomas Fowkes, Freya J. I. Siba, Peter Rogerson, Stephen J. Theander, Thor G. Marfurt, Jutta Price, Ric N. Anstey, Nicholas M. Brown, Graham V. Papenfuss, Anthony T.
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Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

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