Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae

Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment...
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Autor*in:	Wei, Yun [verfasserIn] Cheng, Biao Zhu, Guoding Shen, Danyu Liang, Jiangtao Wang, Cong Wang, Jing Tang, Jianxia Cao, Jun Sharakhov, Igor V. Xia, Ai

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Chromosomal evolution GRIMM Inversion fixation Fluorescence in situ hybridization OrthoDB Synteny blocks

Anmerkung:	© The Author(s) 2017

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 16(2017), 1 vom: 05. Juni
Übergeordnetes Werk:	volume:16 ; year:2017 ; number:1 ; day:05 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12936-017-1888-7

Katalog-ID:	SPR028652738

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245	1	0	\|a Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
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520			\|a Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes.
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912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
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Indexfelder

author_variant	y w yw b c bc g z gz d s ds j l jl c w cw j w jw j t jt j c jc i v s iv ivs a x ax
matchkey_str	article:14752875:2017----::oprtvpyiagnmmpigfaaivcosnpeesnn
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publishDate	2017
allfields	10.1186/s12936-017-1888-7 doi (DE-627)SPR028652738 (SPR)s12936-017-1888-7-e DE-627 ger DE-627 rakwb eng Wei, Yun verfasserin aut Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213 Cheng, Biao aut Zhu, Guoding aut Shen, Danyu aut Liang, Jiangtao aut Wang, Cong aut Wang, Jing aut Tang, Jianxia aut Cao, Jun aut Sharakhov, Igor V. aut Xia, Ai (orcid)0000-0003-0373-9196 aut Enthalten in Malaria journal London : BioMed Central, 2002 16(2017), 1 vom: 05. Juni (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:16 year:2017 number:1 day:05 month:06 https://dx.doi.org/10.1186/s12936-017-1888-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 05 06
spelling	10.1186/s12936-017-1888-7 doi (DE-627)SPR028652738 (SPR)s12936-017-1888-7-e DE-627 ger DE-627 rakwb eng Wei, Yun verfasserin aut Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213 Cheng, Biao aut Zhu, Guoding aut Shen, Danyu aut Liang, Jiangtao aut Wang, Cong aut Wang, Jing aut Tang, Jianxia aut Cao, Jun aut Sharakhov, Igor V. aut Xia, Ai (orcid)0000-0003-0373-9196 aut Enthalten in Malaria journal London : BioMed Central, 2002 16(2017), 1 vom: 05. Juni (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:16 year:2017 number:1 day:05 month:06 https://dx.doi.org/10.1186/s12936-017-1888-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 05 06
allfields_unstemmed	10.1186/s12936-017-1888-7 doi (DE-627)SPR028652738 (SPR)s12936-017-1888-7-e DE-627 ger DE-627 rakwb eng Wei, Yun verfasserin aut Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213 Cheng, Biao aut Zhu, Guoding aut Shen, Danyu aut Liang, Jiangtao aut Wang, Cong aut Wang, Jing aut Tang, Jianxia aut Cao, Jun aut Sharakhov, Igor V. aut Xia, Ai (orcid)0000-0003-0373-9196 aut Enthalten in Malaria journal London : BioMed Central, 2002 16(2017), 1 vom: 05. Juni (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:16 year:2017 number:1 day:05 month:06 https://dx.doi.org/10.1186/s12936-017-1888-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 05 06
allfieldsGer	10.1186/s12936-017-1888-7 doi (DE-627)SPR028652738 (SPR)s12936-017-1888-7-e DE-627 ger DE-627 rakwb eng Wei, Yun verfasserin aut Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213 Cheng, Biao aut Zhu, Guoding aut Shen, Danyu aut Liang, Jiangtao aut Wang, Cong aut Wang, Jing aut Tang, Jianxia aut Cao, Jun aut Sharakhov, Igor V. aut Xia, Ai (orcid)0000-0003-0373-9196 aut Enthalten in Malaria journal London : BioMed Central, 2002 16(2017), 1 vom: 05. Juni (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:16 year:2017 number:1 day:05 month:06 https://dx.doi.org/10.1186/s12936-017-1888-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 05 06
allfieldsSound	10.1186/s12936-017-1888-7 doi (DE-627)SPR028652738 (SPR)s12936-017-1888-7-e DE-627 ger DE-627 rakwb eng Wei, Yun verfasserin aut Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213 Cheng, Biao aut Zhu, Guoding aut Shen, Danyu aut Liang, Jiangtao aut Wang, Cong aut Wang, Jing aut Tang, Jianxia aut Cao, Jun aut Sharakhov, Igor V. aut Xia, Ai (orcid)0000-0003-0373-9196 aut Enthalten in Malaria journal London : BioMed Central, 2002 16(2017), 1 vom: 05. Juni (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:16 year:2017 number:1 day:05 month:06 https://dx.doi.org/10.1186/s12936-017-1888-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 05 06
language	English
source	Enthalten in Malaria journal 16(2017), 1 vom: 05. Juni volume:16 year:2017 number:1 day:05 month:06
sourceStr	Enthalten in Malaria journal 16(2017), 1 vom: 05. Juni volume:16 year:2017 number:1 day:05 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chromosomal evolution GRIMM Inversion fixation Fluorescence in situ hybridization OrthoDB Synteny blocks
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Wei, Yun @@aut@@ Cheng, Biao @@aut@@ Zhu, Guoding @@aut@@ Shen, Danyu @@aut@@ Liang, Jiangtao @@aut@@ Wang, Cong @@aut@@ Wang, Jing @@aut@@ Tang, Jianxia @@aut@@ Cao, Jun @@aut@@ Sharakhov, Igor V. @@aut@@ Xia, Ai @@aut@@
publishDateDaySort_date	2017-06-05T00:00:00Z
hierarchy_top_id	355986582
id	SPR028652738
language_de	englisch
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Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. 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author	Wei, Yun
spellingShingle	Wei, Yun misc Chromosomal evolution misc GRIMM misc Inversion fixation misc Fluorescence in situ hybridization misc OrthoDB misc Synteny blocks Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
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topic_title	Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae Chromosomal evolution (dpeaa)DE-He213 GRIMM (dpeaa)DE-He213 Inversion fixation (dpeaa)DE-He213 Fluorescence in situ hybridization (dpeaa)DE-He213 OrthoDB (dpeaa)DE-He213 Synteny blocks (dpeaa)DE-He213
topic	misc Chromosomal evolution misc GRIMM misc Inversion fixation misc Fluorescence in situ hybridization misc OrthoDB misc Synteny blocks
topic_unstemmed	misc Chromosomal evolution misc GRIMM misc Inversion fixation misc Fluorescence in situ hybridization misc OrthoDB misc Synteny blocks
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title	Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
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title_full	Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
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author_browse	Wei, Yun Cheng, Biao Zhu, Guoding Shen, Danyu Liang, Jiangtao Wang, Cong Wang, Jing Tang, Jianxia Cao, Jun Sharakhov, Igor V. Xia, Ai
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title_sort	comparative physical genome mapping of malaria vectors anopheles sinensis and anopheles gambiae
title_auth	Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
abstract	Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. © The Author(s) 2017
abstractGer	Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. © The Author(s) 2017
abstract_unstemmed	Background Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes. © The Author(s) 2017
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title_short	Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae
url	https://dx.doi.org/10.1186/s12936-017-1888-7
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author2	Cheng, Biao Zhu, Guoding Shen, Danyu Liang, Jiangtao Wang, Cong Wang, Jing Tang, Jianxia Cao, Jun Sharakhov, Igor V. Xia, Ai
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up_date	2024-07-03T20:50:45.866Z
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Comparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiae

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