A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling

Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia,...
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Autor*in:	Ngo, Linh Q. [verfasserIn] Wu, Andrew G. Nguyen, Matthew A. McPherson, Lauren E. Gertner, Elie

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	HMGCR Necrotizing myositis Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase Inflammatory myositis Dysphagia

Anmerkung:	© Ngo et al. 2016

Übergeordnetes Werk:	Enthalten in: BMC ear, nose and throat disorders - [S.l.] : BioMed Central, 2001, 16(2016), 1 vom: 17. Mai
Übergeordnetes Werk:	volume:16 ; year:2016 ; number:1 ; day:17 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12901-016-0027-3

Katalog-ID:	SPR028658485

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520			\|a Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe.
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allfields	10.1186/s12901-016-0027-3 doi (DE-627)SPR028658485 (SPR)s12901-016-0027-3-e DE-627 ger DE-627 rakwb eng Ngo, Linh Q. verfasserin aut A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ngo et al. 2016 Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213 Wu, Andrew G. aut Nguyen, Matthew A. aut McPherson, Lauren E. aut Gertner, Elie aut Enthalten in BMC ear, nose and throat disorders [S.l.] : BioMed Central, 2001 16(2016), 1 vom: 17. Mai (DE-627)355987066 (DE-600)2091302-3 1472-6815 nnns volume:16 year:2016 number:1 day:17 month:05 https://dx.doi.org/10.1186/s12901-016-0027-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2016 1 17 05
spelling	10.1186/s12901-016-0027-3 doi (DE-627)SPR028658485 (SPR)s12901-016-0027-3-e DE-627 ger DE-627 rakwb eng Ngo, Linh Q. verfasserin aut A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ngo et al. 2016 Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213 Wu, Andrew G. aut Nguyen, Matthew A. aut McPherson, Lauren E. aut Gertner, Elie aut Enthalten in BMC ear, nose and throat disorders [S.l.] : BioMed Central, 2001 16(2016), 1 vom: 17. Mai (DE-627)355987066 (DE-600)2091302-3 1472-6815 nnns volume:16 year:2016 number:1 day:17 month:05 https://dx.doi.org/10.1186/s12901-016-0027-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2016 1 17 05
allfields_unstemmed	10.1186/s12901-016-0027-3 doi (DE-627)SPR028658485 (SPR)s12901-016-0027-3-e DE-627 ger DE-627 rakwb eng Ngo, Linh Q. verfasserin aut A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ngo et al. 2016 Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213 Wu, Andrew G. aut Nguyen, Matthew A. aut McPherson, Lauren E. aut Gertner, Elie aut Enthalten in BMC ear, nose and throat disorders [S.l.] : BioMed Central, 2001 16(2016), 1 vom: 17. Mai (DE-627)355987066 (DE-600)2091302-3 1472-6815 nnns volume:16 year:2016 number:1 day:17 month:05 https://dx.doi.org/10.1186/s12901-016-0027-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2016 1 17 05
allfieldsGer	10.1186/s12901-016-0027-3 doi (DE-627)SPR028658485 (SPR)s12901-016-0027-3-e DE-627 ger DE-627 rakwb eng Ngo, Linh Q. verfasserin aut A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ngo et al. 2016 Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213 Wu, Andrew G. aut Nguyen, Matthew A. aut McPherson, Lauren E. aut Gertner, Elie aut Enthalten in BMC ear, nose and throat disorders [S.l.] : BioMed Central, 2001 16(2016), 1 vom: 17. Mai (DE-627)355987066 (DE-600)2091302-3 1472-6815 nnns volume:16 year:2016 number:1 day:17 month:05 https://dx.doi.org/10.1186/s12901-016-0027-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2016 1 17 05
allfieldsSound	10.1186/s12901-016-0027-3 doi (DE-627)SPR028658485 (SPR)s12901-016-0027-3-e DE-627 ger DE-627 rakwb eng Ngo, Linh Q. verfasserin aut A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ngo et al. 2016 Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213 Wu, Andrew G. aut Nguyen, Matthew A. aut McPherson, Lauren E. aut Gertner, Elie aut Enthalten in BMC ear, nose and throat disorders [S.l.] : BioMed Central, 2001 16(2016), 1 vom: 17. Mai (DE-627)355987066 (DE-600)2091302-3 1472-6815 nnns volume:16 year:2016 number:1 day:17 month:05 https://dx.doi.org/10.1186/s12901-016-0027-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2016 1 17 05
language	English
source	Enthalten in BMC ear, nose and throat disorders 16(2016), 1 vom: 17. Mai volume:16 year:2016 number:1 day:17 month:05
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topic_facet	HMGCR Necrotizing myositis Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase Inflammatory myositis Dysphagia
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container_title	BMC ear, nose and throat disorders
authorswithroles_txt_mv	Ngo, Linh Q. @@aut@@ Wu, Andrew G. @@aut@@ Nguyen, Matthew A. @@aut@@ McPherson, Lauren E. @@aut@@ Gertner, Elie @@aut@@
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Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. 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author	Ngo, Linh Q.
spellingShingle	Ngo, Linh Q. misc HMGCR misc Necrotizing myositis misc Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase misc Inflammatory myositis misc Dysphagia A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
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topic_title	A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling HMGCR (dpeaa)DE-He213 Necrotizing myositis (dpeaa)DE-He213 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (dpeaa)DE-He213 Inflammatory myositis (dpeaa)DE-He213 Dysphagia (dpeaa)DE-He213
topic	misc HMGCR misc Necrotizing myositis misc Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase misc Inflammatory myositis misc Dysphagia
topic_unstemmed	misc HMGCR misc Necrotizing myositis misc Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase misc Inflammatory myositis misc Dysphagia
topic_browse	misc HMGCR misc Necrotizing myositis misc Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase misc Inflammatory myositis misc Dysphagia
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title	A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
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title_full	A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
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author_browse	Ngo, Linh Q. Wu, Andrew G. Nguyen, Matthew A. McPherson, Lauren E. Gertner, Elie
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title_sort	case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
title_auth	A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
abstract	Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. © Ngo et al. 2016
abstractGer	Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. © Ngo et al. 2016
abstract_unstemmed	Background Severe dysphagia may occur in the immune mediated necrotizing myopathies (IMNM). Neck swelling and severe dysphagia as the initial symptoms upon presentation has not been previously described. Case presentation A 55-year-old male with a 4 week history of neck swelling, fatigue, dysphagia, myalgias, night sweats, and cough was admitted for an elevated CK. He underwent extensive infectious and inflammatory evaluation including neck imaging and muscle biopsy. Neck CT and MRI showed inflammation throughout his strap muscles, retropharyngeal soft tissues and deltoids. Infectious work up was negative. Deltoid muscle biopsy demonstrated evidence of IMNM. Lab tests revealed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies confirming the diagnosis of HMGCR IMNM. Conclusions HMGCR IMNM is a rare and incompletely understood disease process. Awareness of HMGCR IMNM could potentially lead to earlier diagnosis, treatment and improved clinical outcomes as disease progression can be rapid and severe. © Ngo et al. 2016
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title_short	A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling
url	https://dx.doi.org/10.1186/s12901-016-0027-3
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author2	Wu, Andrew G. Nguyen, Matthew A. McPherson, Lauren E. Gertner, Elie
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A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling

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