Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi

Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Andronescu, Liana R. [verfasserIn] Buchwald, Andrea G. Coalson, Jenna E. Cohee, Lauren Bauleni, Andy Walldorf, Jenny A. Kandangwe, Chifundo Mzilahowa, Themba Taylor, Terrie E. Mathanga, Don P. Laufer, Miriam K.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	ITN Malawi Efficacy Malaria control

Anmerkung:	© The Author(s) 2019

Übergeordnetes Werk:	Enthalten in: Malaria journal - London : BioMed Central, 2002, 18(2019), 1 vom: 24. Sept.
Übergeordnetes Werk:	volume:18 ; year:2019 ; number:1 ; day:24 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12936-019-2930-8

Katalog-ID:	SPR028664310

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100	1		\|a Andronescu, Liana R. \|e verfasserin \|4 aut
245	1	0	\|a Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
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520			\|a Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity.
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700	1		\|a Buchwald, Andrea G. \|4 aut
700	1		\|a Coalson, Jenna E. \|4 aut
700	1		\|a Cohee, Lauren \|4 aut
700	1		\|a Bauleni, Andy \|4 aut
700	1		\|a Walldorf, Jenny A. \|4 aut
700	1		\|a Kandangwe, Chifundo \|4 aut
700	1		\|a Mzilahowa, Themba \|4 aut
700	1		\|a Taylor, Terrie E. \|4 aut
700	1		\|a Mathanga, Don P. \|4 aut
700	1		\|a Laufer, Miriam K. \|0 (orcid)0000-0001-8300-9593 \|4 aut
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912			\|a GBV_ILN_206
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912			\|a GBV_ILN_285
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912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2001
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912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4325
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912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 18 \|j 2019 \|e 1 \|b 24 \|c 09

Indexfelder

author_variant	l r a lr lra a g b ag agb j e c je jec l c lc a b ab j a w ja jaw c k ck t m tm t e t te tet d p m dp dpm m k l mk mkl
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publishDate	2019
allfields	10.1186/s12936-019-2930-8 doi (DE-627)SPR028664310 (SPR)s12936-019-2930-8-e DE-627 ger DE-627 rakwb eng Andronescu, Liana R. verfasserin aut Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213 Buchwald, Andrea G. aut Coalson, Jenna E. aut Cohee, Lauren aut Bauleni, Andy aut Walldorf, Jenny A. aut Kandangwe, Chifundo aut Mzilahowa, Themba aut Taylor, Terrie E. aut Mathanga, Don P. aut Laufer, Miriam K. (orcid)0000-0001-8300-9593 aut Enthalten in Malaria journal London : BioMed Central, 2002 18(2019), 1 vom: 24. Sept. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:18 year:2019 number:1 day:24 month:09 https://dx.doi.org/10.1186/s12936-019-2930-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 24 09
spelling	10.1186/s12936-019-2930-8 doi (DE-627)SPR028664310 (SPR)s12936-019-2930-8-e DE-627 ger DE-627 rakwb eng Andronescu, Liana R. verfasserin aut Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213 Buchwald, Andrea G. aut Coalson, Jenna E. aut Cohee, Lauren aut Bauleni, Andy aut Walldorf, Jenny A. aut Kandangwe, Chifundo aut Mzilahowa, Themba aut Taylor, Terrie E. aut Mathanga, Don P. aut Laufer, Miriam K. (orcid)0000-0001-8300-9593 aut Enthalten in Malaria journal London : BioMed Central, 2002 18(2019), 1 vom: 24. Sept. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:18 year:2019 number:1 day:24 month:09 https://dx.doi.org/10.1186/s12936-019-2930-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 24 09
allfields_unstemmed	10.1186/s12936-019-2930-8 doi (DE-627)SPR028664310 (SPR)s12936-019-2930-8-e DE-627 ger DE-627 rakwb eng Andronescu, Liana R. verfasserin aut Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213 Buchwald, Andrea G. aut Coalson, Jenna E. aut Cohee, Lauren aut Bauleni, Andy aut Walldorf, Jenny A. aut Kandangwe, Chifundo aut Mzilahowa, Themba aut Taylor, Terrie E. aut Mathanga, Don P. aut Laufer, Miriam K. (orcid)0000-0001-8300-9593 aut Enthalten in Malaria journal London : BioMed Central, 2002 18(2019), 1 vom: 24. Sept. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:18 year:2019 number:1 day:24 month:09 https://dx.doi.org/10.1186/s12936-019-2930-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 24 09
allfieldsGer	10.1186/s12936-019-2930-8 doi (DE-627)SPR028664310 (SPR)s12936-019-2930-8-e DE-627 ger DE-627 rakwb eng Andronescu, Liana R. verfasserin aut Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213 Buchwald, Andrea G. aut Coalson, Jenna E. aut Cohee, Lauren aut Bauleni, Andy aut Walldorf, Jenny A. aut Kandangwe, Chifundo aut Mzilahowa, Themba aut Taylor, Terrie E. aut Mathanga, Don P. aut Laufer, Miriam K. (orcid)0000-0001-8300-9593 aut Enthalten in Malaria journal London : BioMed Central, 2002 18(2019), 1 vom: 24. Sept. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:18 year:2019 number:1 day:24 month:09 https://dx.doi.org/10.1186/s12936-019-2930-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 24 09
allfieldsSound	10.1186/s12936-019-2930-8 doi (DE-627)SPR028664310 (SPR)s12936-019-2930-8-e DE-627 ger DE-627 rakwb eng Andronescu, Liana R. verfasserin aut Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213 Buchwald, Andrea G. aut Coalson, Jenna E. aut Cohee, Lauren aut Bauleni, Andy aut Walldorf, Jenny A. aut Kandangwe, Chifundo aut Mzilahowa, Themba aut Taylor, Terrie E. aut Mathanga, Don P. aut Laufer, Miriam K. (orcid)0000-0001-8300-9593 aut Enthalten in Malaria journal London : BioMed Central, 2002 18(2019), 1 vom: 24. Sept. (DE-627)355986582 (DE-600)2091229-8 1475-2875 nnns volume:18 year:2019 number:1 day:24 month:09 https://dx.doi.org/10.1186/s12936-019-2930-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 24 09
language	English
source	Enthalten in Malaria journal 18(2019), 1 vom: 24. Sept. volume:18 year:2019 number:1 day:24 month:09
sourceStr	Enthalten in Malaria journal 18(2019), 1 vom: 24. Sept. volume:18 year:2019 number:1 day:24 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ITN Malawi Efficacy Malaria control
isfreeaccess_bool	true
container_title	Malaria journal
authorswithroles_txt_mv	Andronescu, Liana R. @@aut@@ Buchwald, Andrea G. @@aut@@ Coalson, Jenna E. @@aut@@ Cohee, Lauren @@aut@@ Bauleni, Andy @@aut@@ Walldorf, Jenny A. @@aut@@ Kandangwe, Chifundo @@aut@@ Mzilahowa, Themba @@aut@@ Taylor, Terrie E. @@aut@@ Mathanga, Don P. @@aut@@ Laufer, Miriam K. @@aut@@
publishDateDaySort_date	2019-09-24T00:00:00Z
hierarchy_top_id	355986582
id	SPR028664310
language_de	englisch
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Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. 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author	Andronescu, Liana R.
spellingShingle	Andronescu, Liana R. misc ITN misc Malawi misc Efficacy misc Malaria control Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
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topic_title	Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi ITN (dpeaa)DE-He213 Malawi (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Malaria control (dpeaa)DE-He213
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title	Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
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title_full	Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
author_sort	Andronescu, Liana R.
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author_browse	Andronescu, Liana R. Buchwald, Andrea G. Coalson, Jenna E. Cohee, Lauren Bauleni, Andy Walldorf, Jenny A. Kandangwe, Chifundo Mzilahowa, Themba Taylor, Terrie E. Mathanga, Don P. Laufer, Miriam K.
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title_sort	net age, but not integrity, may be associated with decreased protection against plasmodium falciparum infection in southern malawi
title_auth	Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
abstract	Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. © The Author(s) 2019
abstractGer	Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. © The Author(s) 2019
abstract_unstemmed	Background Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity. © The Author(s) 2019
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title_short	Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi
url	https://dx.doi.org/10.1186/s12936-019-2930-8
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author2	Buchwald, Andrea G. Coalson, Jenna E. Cohee, Lauren Bauleni, Andy Walldorf, Jenny A. Kandangwe, Chifundo Mzilahowa, Themba Taylor, Terrie E. Mathanga, Don P. Laufer, Miriam K.
author2Str	Buchwald, Andrea G. Coalson, Jenna E. Cohee, Lauren Bauleni, Andy Walldorf, Jenny A. Kandangwe, Chifundo Mzilahowa, Themba Taylor, Terrie E. Mathanga, Don P. Laufer, Miriam K.
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doi_str	10.1186/s12936-019-2930-8
up_date	2024-07-03T20:55:52.462Z
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Previous studies have addressed ITN ownership, insecticide resistance, and frequency of ITN use as possible contributing factors to the high prevalence of malaria infection despite high ITN coverage, but have rarely considered whether the condition of the ITN, or how many people use it, impacts efficacy. This study assessed how ITN integrity, ITN age, and the number of persons sharing a net might mitigate or reduce protective efficacy among self-identified ITN users in Malawi. Methods From 2012 to 2014, six cross-sectional surveys were conducted in both the rainy and dry seasons in southern Malawi. Data were collected on ITN use, integrity (number and size of holes), and age. Blood samples for detecting Plasmodium falciparum infection were obtained from reported ITN users over 6 months of age. Generalized linear mixed models were used to account for clustering at the household and community level. The final model controlled for gender, household eaves, and community-level infection prevalence during the rainy season. Results There were 9646 ITN users with blood samples across six surveys, 15% of whom tested positive for P. falciparum infection. Among children under 5 years old, there was a 50% increased odds of P. falciparum infection among those sleeping under an ITN older than two years, compared to those using an ITN less than 2 years old (OR = 1.50; 95% CI 1.07–2.08). ITN integrity and number of individuals sharing an ITN were not associated with P. falciparum infection. Conclusions Older ITNs were associated with higher rates of P. falciparum in young children, which may indicate that insecticide concentrations play a larger role in infection prevention than the physical barrier of an ITN. ITN use was self-reported and the integrity measures lacked the precision of newer methods, suggesting a need for objective measures of ITN use and more precise assessment of ITN integrity.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ITN</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Malawi</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Efficacy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Malaria control</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Buchwald, Andrea G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coalson, Jenna E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cohee, Lauren</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bauleni, Andy</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Walldorf, Jenny A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kandangwe, Chifundo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mzilahowa, Themba</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Taylor, Terrie E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mathanga, Don P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Laufer, Miriam K.</subfield><subfield code="0">(orcid)0000-0001-8300-9593</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Malaria journal</subfield><subfield code="d">London : BioMed Central, 2002</subfield><subfield code="g">18(2019), 1 vom: 24. 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Net age, but not integrity, may be associated with decreased protection against Plasmodium falciparum infection in southern Malawi

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