Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise
Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxid...
Ausführliche Beschreibung
Autor*in: |
Hamid, Noor Aini Abd [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2011 |
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Anmerkung: |
© Abd Hamid et al; licensee BioMed Central Ltd. 2011 |
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Übergeordnetes Werk: |
Enthalten in: Nutrition journal - London : BioMed Central, 2002, 10(2011), 1 vom: 23. Apr. |
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Übergeordnetes Werk: |
volume:10 ; year:2011 ; number:1 ; day:23 ; month:04 |
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DOI / URN: |
10.1186/1475-2891-10-37 |
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Katalog-ID: |
SPR028670981 |
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100 | 1 | |a Hamid, Noor Aini Abd |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise |
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520 | |a Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. | ||
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650 | 4 | |a Sedentary Control Group |7 (dpeaa)DE-He213 | |
650 | 4 | |a Exercise Training Protocol |7 (dpeaa)DE-He213 | |
700 | 1 | |a Hasrul, Mohd A |4 aut | |
700 | 1 | |a Ruzanna, Rusdiah J |4 aut | |
700 | 1 | |a Ibrahim, Ibrahim A |4 aut | |
700 | 1 | |a Baruah, Prasamit S |4 aut | |
700 | 1 | |a Mazlan, Musalmah |4 aut | |
700 | 1 | |a Yusof, Yasmin Anum Mohd |4 aut | |
700 | 1 | |a Ngah, Wan Zurinah Wan |4 aut | |
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10.1186/1475-2891-10-37 doi (DE-627)SPR028670981 (SPR)1475-2891-10-37-e DE-627 ger DE-627 rakwb eng Hamid, Noor Aini Abd verfasserin aut Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Abd Hamid et al; licensee BioMed Central Ltd. 2011 Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 Hasrul, Mohd A aut Ruzanna, Rusdiah J aut Ibrahim, Ibrahim A aut Baruah, Prasamit S aut Mazlan, Musalmah aut Yusof, Yasmin Anum Mohd aut Ngah, Wan Zurinah Wan aut Enthalten in Nutrition journal London : BioMed Central, 2002 10(2011), 1 vom: 23. Apr. (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:10 year:2011 number:1 day:23 month:04 https://dx.doi.org/10.1186/1475-2891-10-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1 23 04 |
spelling |
10.1186/1475-2891-10-37 doi (DE-627)SPR028670981 (SPR)1475-2891-10-37-e DE-627 ger DE-627 rakwb eng Hamid, Noor Aini Abd verfasserin aut Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Abd Hamid et al; licensee BioMed Central Ltd. 2011 Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 Hasrul, Mohd A aut Ruzanna, Rusdiah J aut Ibrahim, Ibrahim A aut Baruah, Prasamit S aut Mazlan, Musalmah aut Yusof, Yasmin Anum Mohd aut Ngah, Wan Zurinah Wan aut Enthalten in Nutrition journal London : BioMed Central, 2002 10(2011), 1 vom: 23. Apr. (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:10 year:2011 number:1 day:23 month:04 https://dx.doi.org/10.1186/1475-2891-10-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1 23 04 |
allfields_unstemmed |
10.1186/1475-2891-10-37 doi (DE-627)SPR028670981 (SPR)1475-2891-10-37-e DE-627 ger DE-627 rakwb eng Hamid, Noor Aini Abd verfasserin aut Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Abd Hamid et al; licensee BioMed Central Ltd. 2011 Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 Hasrul, Mohd A aut Ruzanna, Rusdiah J aut Ibrahim, Ibrahim A aut Baruah, Prasamit S aut Mazlan, Musalmah aut Yusof, Yasmin Anum Mohd aut Ngah, Wan Zurinah Wan aut Enthalten in Nutrition journal London : BioMed Central, 2002 10(2011), 1 vom: 23. Apr. (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:10 year:2011 number:1 day:23 month:04 https://dx.doi.org/10.1186/1475-2891-10-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1 23 04 |
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10.1186/1475-2891-10-37 doi (DE-627)SPR028670981 (SPR)1475-2891-10-37-e DE-627 ger DE-627 rakwb eng Hamid, Noor Aini Abd verfasserin aut Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Abd Hamid et al; licensee BioMed Central Ltd. 2011 Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 Hasrul, Mohd A aut Ruzanna, Rusdiah J aut Ibrahim, Ibrahim A aut Baruah, Prasamit S aut Mazlan, Musalmah aut Yusof, Yasmin Anum Mohd aut Ngah, Wan Zurinah Wan aut Enthalten in Nutrition journal London : BioMed Central, 2002 10(2011), 1 vom: 23. Apr. (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:10 year:2011 number:1 day:23 month:04 https://dx.doi.org/10.1186/1475-2891-10-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1 23 04 |
allfieldsSound |
10.1186/1475-2891-10-37 doi (DE-627)SPR028670981 (SPR)1475-2891-10-37-e DE-627 ger DE-627 rakwb eng Hamid, Noor Aini Abd verfasserin aut Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Abd Hamid et al; licensee BioMed Central Ltd. 2011 Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 Hasrul, Mohd A aut Ruzanna, Rusdiah J aut Ibrahim, Ibrahim A aut Baruah, Prasamit S aut Mazlan, Musalmah aut Yusof, Yasmin Anum Mohd aut Ngah, Wan Zurinah Wan aut Enthalten in Nutrition journal London : BioMed Central, 2002 10(2011), 1 vom: 23. Apr. (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:10 year:2011 number:1 day:23 month:04 https://dx.doi.org/10.1186/1475-2891-10-37 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2011 1 23 04 |
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Hamid, Noor Aini Abd @@aut@@ Hasrul, Mohd A @@aut@@ Ruzanna, Rusdiah J @@aut@@ Ibrahim, Ibrahim A @@aut@@ Baruah, Prasamit S @@aut@@ Mazlan, Musalmah @@aut@@ Yusof, Yasmin Anum Mohd @@aut@@ Ngah, Wan Zurinah Wan @@aut@@ |
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The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. 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Hamid, Noor Aini Abd misc Comet Assay misc Exercise Group misc Sedentary Group misc Sedentary Control Group misc Exercise Training Protocol Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise |
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Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise Comet Assay (dpeaa)DE-He213 Exercise Group (dpeaa)DE-He213 Sedentary Group (dpeaa)DE-He213 Sedentary Control Group (dpeaa)DE-He213 Exercise Training Protocol (dpeaa)DE-He213 |
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Hamid, Noor Aini Abd Hasrul, Mohd A Ruzanna, Rusdiah J Ibrahim, Ibrahim A Baruah, Prasamit S Mazlan, Musalmah Yusof, Yasmin Anum Mohd Ngah, Wan Zurinah Wan |
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effect of vitamin e (tri $ e^{®} $) on antioxidant enzymes and dna damage in rats following eight weeks exercise |
title_auth |
Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise |
abstract |
Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. © Abd Hamid et al; licensee BioMed Central Ltd. 2011 |
abstractGer |
Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. © Abd Hamid et al; licensee BioMed Central Ltd. 2011 |
abstract_unstemmed |
Background Exercise is beneficial to health, but during exercise the body generates reactive oxygen species (ROS) which are known to result in oxidative stress. The present study analysed the effects of vitamin E (Tri $ E^{®} $) on antioxidant enzymes; superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (Cat) activity and DNA damage in rats undergoing eight weeks exercise. Methods Twenty four Sprague-Dawley rats (weighing 320-370 gm) were divided into four groups; a control group of sedentary rats which were given a normal diet, second group of sedentary rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $, third group comprised of exercised rats on a normal diet, and the fourth group of exercised rats with oral supplementation of 30 mg/kg/d of Tri $ E^{®} $. The exercising rats were trained on a treadmill for 30 minutes per day for 8 weeks. Blood samples were taken before and after 8 weeks of the study to determine SOD, GPx, Cat activities and DNA damage. Results SOD activity decreased significantly in all the groups compared to baseline, however both exercised groups showed significant reduction in SOD activity as compared to the sedentary groups. Sedentary control groups showed significantly higher GPx and Cat activity compared to baseline and exercised groups. The supplemented groups, both exercised and non exercised groups, showed significant decrease in Cat activity as compared to their control groups with normal diet. DNA damage was significantly higher in exercising rats as compared to sedentary control. However in exercising groups, the DNA damage in supplemented group is significantly lower as compared to the non-supplemented group. Conclusions In conclusion, antioxidant enzymes activity were generally reduced in rats supplemented with Tri $ E^{®} $ probably due to its synergistic anti-oxidative defence, as evidenced by the decrease in DNA damage in Tri $ E^{®} $ supplemented exercise group. © Abd Hamid et al; licensee BioMed Central Ltd. 2011 |
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Effect of vitamin E (Tri $ E^{®} $) on antioxidant enzymes and DNA damage in rats following eight weeks exercise |
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Hasrul, Mohd A Ruzanna, Rusdiah J Ibrahim, Ibrahim A Baruah, Prasamit S Mazlan, Musalmah Yusof, Yasmin Anum Mohd Ngah, Wan Zurinah Wan |
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|
score |
7.3995056 |