Prognosis of breast cancer is associated with one-carbon metabolism related nutrients among Korean women

Background The 5-year survival rate for breast cancer among Korean women has increased steadily; however, breast cancer remains the leading cause of cancer mortality among women. One-carbon metabolism, which requires an adequate supply of methyl group donors and B vitamins, may affect the prognosis...
Ausführliche Beschreibung

Background The 5-year survival rate for breast cancer among Korean women has increased steadily; however, breast cancer remains the leading cause of cancer mortality among women. One-carbon metabolism, which requires an adequate supply of methyl group donors and B vitamins, may affect the prognosis of breast cancer. This aim of this study was to investigate the associations of dietary intake of vitamin $ B_{2} $, vitamin $ B_{6} $ and folate before diagnosis on the prognosis of breast cancer. Methods We assessed the dietary intake using a food frequency questionnaire with 980 women who were newly diagnosed and histopathologically confirmed to have primary breast cancer from hospitals in Korea, and 141 disease progression events occurred. Cox’s proportional hazard regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) adjusting for age, education, recruitment sites, TNM stage, hormone status, nuclear grade and total calorie. Results There was no significant association between any one-carbon metabolism related nutrients (vitamin $ B_{2} $, $ B_{6} $ and folate) and the progression of breast cancer overall. However, one-carbon metabolism related nutrients were associated with disease progression in breast cancer patients stratified by subtypes. In ER + and/or PR + breast cancers, no association was observed; however, in ER–/PR– breast cancers, a high intake of vitamin $ B_{2} $ and folate statistically elevated the HR of breast cancer progression (HR = 2.28; 95% CI, 1.20-4.35, HR = 1.84; 95% CI, 1.02-3.32, respectively) compared to a low intake. This positive association between the ER/PR status and progression of the disease was profound when the nutrient intakes were categorized in a combined score ($ P_{interaction} $ = 0.018). In ER–/PR– breast cancers, high combined scores were associated with a significantly poor DFS compared to those belonging to the low score group (HR = 3.84; 95% CI, 1.70-8.71). Conclusions In conclusion, our results suggest that one-carbon related nutrients have a role in the prognosis of breast cancer depending on the ER/PR status. Ausführliche Beschreibung

Autor*in:	Lee, Yunhee [verfasserIn] Lee, Sang-Ah Choi, Ji-Yeob Song, Minkyo Sung, Hyuna Jeon, Sujee Park, Sue K Yoo, Keun-Young Noh, Dong-Young Ahn, Sei-Hyun Kang, Daehee

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Breast cancer prognosis One-carbon metabolism Vitamin B Folate

Anmerkung:	© Lee et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Nutrition journal - London : BioMed Central, 2002, 11(2012), 1 vom: 28. Aug.
Übergeordnetes Werk:	volume:11 ; year:2012 ; number:1 ; day:28 ; month:08

Links:	Volltext

DOI / URN:	10.1186/1475-2891-11-59

Katalog-ID:	SPR028672658