Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth

Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up...
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Autor*in:	Melnik, Bodo C [verfasserIn] John, Swen Malte Schmitz, Gerd

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Branched-chain amino acids Diseases of civilization Glucose-dependent insulinotropic polypeptide Glucagon-like peptide-1 Exosomal microRNA Leucine MicroRNA-21 Milk mTORC1 Postnatal growth Tryptophan

Anmerkung:	© Melnik et al.; licensee BioMed Central Ltd. 2013

Übergeordnetes Werk:	Enthalten in: Nutrition journal - London : BioMed Central, 2002, 12(2013), 1 vom: 25. Juli
Übergeordnetes Werk:	volume:12 ; year:2013 ; number:1 ; day:25 ; month:07

Links:	Volltext

DOI / URN:	10.1186/1475-2891-12-103

Katalog-ID:	SPR028674510

Internformat


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publishDate	2013
allfields	10.1186/1475-2891-12-103 doi (DE-627)SPR028674510 (SPR)1475-2891-12-103-e DE-627 ger DE-627 rakwb eng Melnik, Bodo C verfasserin aut Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Melnik et al.; licensee BioMed Central Ltd. 2013 Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 John, Swen Malte aut Schmitz, Gerd aut Enthalten in Nutrition journal London : BioMed Central, 2002 12(2013), 1 vom: 25. Juli (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:12 year:2013 number:1 day:25 month:07 https://dx.doi.org/10.1186/1475-2891-12-103 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1 25 07
spelling	10.1186/1475-2891-12-103 doi (DE-627)SPR028674510 (SPR)1475-2891-12-103-e DE-627 ger DE-627 rakwb eng Melnik, Bodo C verfasserin aut Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Melnik et al.; licensee BioMed Central Ltd. 2013 Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 John, Swen Malte aut Schmitz, Gerd aut Enthalten in Nutrition journal London : BioMed Central, 2002 12(2013), 1 vom: 25. Juli (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:12 year:2013 number:1 day:25 month:07 https://dx.doi.org/10.1186/1475-2891-12-103 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1 25 07
allfields_unstemmed	10.1186/1475-2891-12-103 doi (DE-627)SPR028674510 (SPR)1475-2891-12-103-e DE-627 ger DE-627 rakwb eng Melnik, Bodo C verfasserin aut Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Melnik et al.; licensee BioMed Central Ltd. 2013 Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 John, Swen Malte aut Schmitz, Gerd aut Enthalten in Nutrition journal London : BioMed Central, 2002 12(2013), 1 vom: 25. Juli (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:12 year:2013 number:1 day:25 month:07 https://dx.doi.org/10.1186/1475-2891-12-103 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1 25 07
allfieldsGer	10.1186/1475-2891-12-103 doi (DE-627)SPR028674510 (SPR)1475-2891-12-103-e DE-627 ger DE-627 rakwb eng Melnik, Bodo C verfasserin aut Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Melnik et al.; licensee BioMed Central Ltd. 2013 Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 John, Swen Malte aut Schmitz, Gerd aut Enthalten in Nutrition journal London : BioMed Central, 2002 12(2013), 1 vom: 25. Juli (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:12 year:2013 number:1 day:25 month:07 https://dx.doi.org/10.1186/1475-2891-12-103 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1 25 07
allfieldsSound	10.1186/1475-2891-12-103 doi (DE-627)SPR028674510 (SPR)1475-2891-12-103-e DE-627 ger DE-627 rakwb eng Melnik, Bodo C verfasserin aut Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Melnik et al.; licensee BioMed Central Ltd. 2013 Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 John, Swen Malte aut Schmitz, Gerd aut Enthalten in Nutrition journal London : BioMed Central, 2002 12(2013), 1 vom: 25. Juli (DE-627)355989441 (DE-600)2091602-4 1475-2891 nnns volume:12 year:2013 number:1 day:25 month:07 https://dx.doi.org/10.1186/1475-2891-12-103 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2013 1 25 07
language	English
source	Enthalten in Nutrition journal 12(2013), 1 vom: 25. Juli volume:12 year:2013 number:1 day:25 month:07
sourceStr	Enthalten in Nutrition journal 12(2013), 1 vom: 25. Juli volume:12 year:2013 number:1 day:25 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Branched-chain amino acids Diseases of civilization Glucose-dependent insulinotropic polypeptide Glucagon-like peptide-1 Exosomal microRNA Leucine MicroRNA-21 Milk mTORC1 Postnatal growth Tryptophan
isfreeaccess_bool	true
container_title	Nutrition journal
authorswithroles_txt_mv	Melnik, Bodo C @@aut@@ John, Swen Malte @@aut@@ Schmitz, Gerd @@aut@@
publishDateDaySort_date	2013-07-25T00:00:00Z
hierarchy_top_id	355989441
id	SPR028674510
language_de	englisch
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author	Melnik, Bodo C
spellingShingle	Melnik, Bodo C misc Branched-chain amino acids misc Diseases of civilization misc Glucose-dependent insulinotropic polypeptide misc Glucagon-like peptide-1 misc Exosomal microRNA misc Leucine misc MicroRNA-21 misc Milk misc mTORC1 misc Postnatal growth misc Tryptophan Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
authorStr	Melnik, Bodo C
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topic_title	Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth Branched-chain amino acids (dpeaa)DE-He213 Diseases of civilization (dpeaa)DE-He213 Glucose-dependent insulinotropic polypeptide (dpeaa)DE-He213 Glucagon-like peptide-1 (dpeaa)DE-He213 Exosomal microRNA (dpeaa)DE-He213 Leucine (dpeaa)DE-He213 MicroRNA-21 (dpeaa)DE-He213 Milk (dpeaa)DE-He213 mTORC1 (dpeaa)DE-He213 Postnatal growth (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213
topic	misc Branched-chain amino acids misc Diseases of civilization misc Glucose-dependent insulinotropic polypeptide misc Glucagon-like peptide-1 misc Exosomal microRNA misc Leucine misc MicroRNA-21 misc Milk misc mTORC1 misc Postnatal growth misc Tryptophan
topic_unstemmed	misc Branched-chain amino acids misc Diseases of civilization misc Glucose-dependent insulinotropic polypeptide misc Glucagon-like peptide-1 misc Exosomal microRNA misc Leucine misc MicroRNA-21 misc Milk misc mTORC1 misc Postnatal growth misc Tryptophan
topic_browse	misc Branched-chain amino acids misc Diseases of civilization misc Glucose-dependent insulinotropic polypeptide misc Glucagon-like peptide-1 misc Exosomal microRNA misc Leucine misc MicroRNA-21 misc Milk misc mTORC1 misc Postnatal growth misc Tryptophan
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title	Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
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title_full	Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
author_sort	Melnik, Bodo C
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author-letter	Melnik, Bodo C
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title_sort	milk is not just food but most likely a genetic transfection system activating mtorc1 signaling for postnatal growth
title_auth	Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
abstract	Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. © Melnik et al.; licensee BioMed Central Ltd. 2013
abstractGer	Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. © Melnik et al.; licensee BioMed Central Ltd. 2013
abstract_unstemmed	Abstract Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization. © Melnik et al.; licensee BioMed Central Ltd. 2013
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title_short	Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
url	https://dx.doi.org/10.1186/1475-2891-12-103
remote_bool	true
author2	John, Swen Malte Schmitz, Gerd
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doi_str	10.1186/1475-2891-12-103
up_date	2024-07-03T21:00:07.339Z
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