A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease
Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dyna...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shi, Changzheng [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2017 |
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| Übergeordnetes Werk: |
Enthalten in: Biomedical engineering online - London : BioMed Central, 2002, 16(2017), 1 vom: 14. Apr. |
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| Übergeordnetes Werk: |
volume:16 ; year:2017 ; number:1 ; day:14 ; month:04 |
| Links: |
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| DOI / URN: |
10.1186/s12938-017-0330-2 |
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| Katalog-ID: |
SPR028697138 |
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| 245 | 1 | 2 | |a A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease |
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| 520 | |a Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. | ||
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| 700 | 1 | |a Zhang, Tao |4 aut | |
| 700 | 1 | |a Luo, Liangping |4 aut | |
| 700 | 1 | |a Liu, Xin |4 aut | |
| 700 | 1 | |a Zhang, Heye |4 aut | |
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10.1186/s12938-017-0330-2 doi (DE-627)SPR028697138 (SPR)s12938-017-0330-2-e DE-627 ger DE-627 rakwb eng Shi, Changzheng verfasserin aut A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 Zhang, Dong aut Cao, Kunlin aut Zhang, Tao aut Luo, Liangping aut Liu, Xin aut Zhang, Heye aut Enthalten in Biomedical engineering online London : BioMed Central, 2002 16(2017), 1 vom: 14. Apr. (DE-627)35210547X (DE-600)2084374-4 1475-925X nnns volume:16 year:2017 number:1 day:14 month:04 https://dx.doi.org/10.1186/s12938-017-0330-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 14 04 |
| spelling |
10.1186/s12938-017-0330-2 doi (DE-627)SPR028697138 (SPR)s12938-017-0330-2-e DE-627 ger DE-627 rakwb eng Shi, Changzheng verfasserin aut A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 Zhang, Dong aut Cao, Kunlin aut Zhang, Tao aut Luo, Liangping aut Liu, Xin aut Zhang, Heye aut Enthalten in Biomedical engineering online London : BioMed Central, 2002 16(2017), 1 vom: 14. Apr. (DE-627)35210547X (DE-600)2084374-4 1475-925X nnns volume:16 year:2017 number:1 day:14 month:04 https://dx.doi.org/10.1186/s12938-017-0330-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 14 04 |
| allfields_unstemmed |
10.1186/s12938-017-0330-2 doi (DE-627)SPR028697138 (SPR)s12938-017-0330-2-e DE-627 ger DE-627 rakwb eng Shi, Changzheng verfasserin aut A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 Zhang, Dong aut Cao, Kunlin aut Zhang, Tao aut Luo, Liangping aut Liu, Xin aut Zhang, Heye aut Enthalten in Biomedical engineering online London : BioMed Central, 2002 16(2017), 1 vom: 14. Apr. (DE-627)35210547X (DE-600)2084374-4 1475-925X nnns volume:16 year:2017 number:1 day:14 month:04 https://dx.doi.org/10.1186/s12938-017-0330-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 14 04 |
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10.1186/s12938-017-0330-2 doi (DE-627)SPR028697138 (SPR)s12938-017-0330-2-e DE-627 ger DE-627 rakwb eng Shi, Changzheng verfasserin aut A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 Zhang, Dong aut Cao, Kunlin aut Zhang, Tao aut Luo, Liangping aut Liu, Xin aut Zhang, Heye aut Enthalten in Biomedical engineering online London : BioMed Central, 2002 16(2017), 1 vom: 14. Apr. (DE-627)35210547X (DE-600)2084374-4 1475-925X nnns volume:16 year:2017 number:1 day:14 month:04 https://dx.doi.org/10.1186/s12938-017-0330-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 14 04 |
| allfieldsSound |
10.1186/s12938-017-0330-2 doi (DE-627)SPR028697138 (SPR)s12938-017-0330-2-e DE-627 ger DE-627 rakwb eng Shi, Changzheng verfasserin aut A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 Zhang, Dong aut Cao, Kunlin aut Zhang, Tao aut Luo, Liangping aut Liu, Xin aut Zhang, Heye aut Enthalten in Biomedical engineering online London : BioMed Central, 2002 16(2017), 1 vom: 14. Apr. (DE-627)35210547X (DE-600)2084374-4 1475-925X nnns volume:16 year:2017 number:1 day:14 month:04 https://dx.doi.org/10.1186/s12938-017-0330-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 14 04 |
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Shi, Changzheng @@aut@@ Zhang, Dong @@aut@@ Cao, Kunlin @@aut@@ Zhang, Tao @@aut@@ Luo, Liangping @@aut@@ Liu, Xin @@aut@@ Zhang, Heye @@aut@@ |
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Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CCTA</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">FFR</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">FFR</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CFD</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Dong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cao, Kunlin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Tao</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Luo, Liangping</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liu, Xin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Heye</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Biomedical engineering online</subfield><subfield code="d">London : BioMed Central, 2002</subfield><subfield code="g">16(2017), 1 vom: 14. 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Shi, Changzheng misc CCTA misc FFR misc CFD A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease |
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A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease CCTA (dpeaa)DE-He213 FFR (dpeaa)DE-He213 CFD (dpeaa)DE-He213 |
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A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease |
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Shi, Changzheng |
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Shi, Changzheng Zhang, Dong Cao, Kunlin Zhang, Tao Luo, Liangping Liu, Xin Zhang, Heye |
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study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease |
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A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease |
| abstract |
Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. © The Author(s) 2017 |
| abstractGer |
Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. © The Author(s) 2017 |
| abstract_unstemmed |
Background The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. Ischaemia was defined as an FFR or $ FFR_{CTA} $ ≤0.80, and anatomically obstructive CAD was defined as a CCTA stenosis >50%. Results $ FFR_{CTA} $ and invasive FFR were well correlated (r = 0.742, P = 0.001). Slight systematic underestimation was found in $ FFR_{CTA} $ (mean difference 0.03, standard deviation 0.05, P = 0.001). The area under the receiver-operating characteristic curve was 0.93 for $ FFR_{CTA} $ and 0.75 for CCTA on a per-vessel basis. Per-patient accuracy, sensitivity and specificity were 79.3, 93.7 and 61.5%, respectively, for $ FFR_{CTA} $ and 62.1, 87.5 and 30.7%, respectively, for CCTA. Per-vessel accuracy, sensitivity and specificity were 80.6, 94.1 and 68.4%, respectively, for $ FFR_{CTA} $ and 61.6, 88.2 and 36.8%, respectively, for CCTA. Conclusions $ FFR_{CTA} $ derived from pulsatile simulation with a simplified novel boundary condition was in good agreement with invasive FFR and showed better diagnostic performance compared to CCTA, suggesting that the simplified method has the potential to be an alternative and accurate way to assess the haemodynamic characteristics for coronary stenosis. © The Author(s) 2017 |
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Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of $ FFR_{CTA} $ requires further evaluation. Objectives The aim of this study was to investigate the diagnostic performance of $ FFR_{CTA} $ calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making. Methods Twenty-nine subjects included in this study underwent CCTA before undergoing clinically indicated invasive coronary angiography for suspected coronary artery disease. Pulsatile flow simulation and a novel boundary condition were used to obtain $ FFR_{CTA} $ based on the CCTA datasets. The Pearson correlation, Bland–Altman plots and the diagnostic performance of $ FFR_{CTA} $ and CCTA stenosis were analyzed by comparison to the invasive FFR reference standard. 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