Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity

Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to th...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Guclu, Metin [verfasserIn] Cander, Soner Kiyici, Sinem Vatansever, Ebru Hacihasanoğlu, Arif Bayram Kisakol, Gurcan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Pregnancy Prolactin Macroprolactin Thyroid dysfunction Thyroid autoimmunity

Anmerkung:	© Guclu et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC endocrine disorders - [S.l.] : BioMed Central, 2001, 15(2015), 1 vom: 20. Juni
Übergeordnetes Werk:	volume:15 ; year:2015 ; number:1 ; day:20 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12902-015-0025-2

Katalog-ID:	SPR028699610

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520			\|a Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy.
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allfields	10.1186/s12902-015-0025-2 doi (DE-627)SPR028699610 (SPR)s12902-015-0025-2-e DE-627 ger DE-627 rakwb eng Guclu, Metin verfasserin aut Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Guclu et al. 2015 Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213 Cander, Soner aut Kiyici, Sinem aut Vatansever, Ebru aut Hacihasanoğlu, Arif Bayram aut Kisakol, Gurcan aut Enthalten in BMC endocrine disorders [S.l.] : BioMed Central, 2001 15(2015), 1 vom: 20. Juni (DE-627)355456575 (DE-600)2091323-0 1472-6823 nnns volume:15 year:2015 number:1 day:20 month:06 https://dx.doi.org/10.1186/s12902-015-0025-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 06
spelling	10.1186/s12902-015-0025-2 doi (DE-627)SPR028699610 (SPR)s12902-015-0025-2-e DE-627 ger DE-627 rakwb eng Guclu, Metin verfasserin aut Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Guclu et al. 2015 Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213 Cander, Soner aut Kiyici, Sinem aut Vatansever, Ebru aut Hacihasanoğlu, Arif Bayram aut Kisakol, Gurcan aut Enthalten in BMC endocrine disorders [S.l.] : BioMed Central, 2001 15(2015), 1 vom: 20. Juni (DE-627)355456575 (DE-600)2091323-0 1472-6823 nnns volume:15 year:2015 number:1 day:20 month:06 https://dx.doi.org/10.1186/s12902-015-0025-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 06
allfields_unstemmed	10.1186/s12902-015-0025-2 doi (DE-627)SPR028699610 (SPR)s12902-015-0025-2-e DE-627 ger DE-627 rakwb eng Guclu, Metin verfasserin aut Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Guclu et al. 2015 Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213 Cander, Soner aut Kiyici, Sinem aut Vatansever, Ebru aut Hacihasanoğlu, Arif Bayram aut Kisakol, Gurcan aut Enthalten in BMC endocrine disorders [S.l.] : BioMed Central, 2001 15(2015), 1 vom: 20. Juni (DE-627)355456575 (DE-600)2091323-0 1472-6823 nnns volume:15 year:2015 number:1 day:20 month:06 https://dx.doi.org/10.1186/s12902-015-0025-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 06
allfieldsGer	10.1186/s12902-015-0025-2 doi (DE-627)SPR028699610 (SPR)s12902-015-0025-2-e DE-627 ger DE-627 rakwb eng Guclu, Metin verfasserin aut Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Guclu et al. 2015 Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213 Cander, Soner aut Kiyici, Sinem aut Vatansever, Ebru aut Hacihasanoğlu, Arif Bayram aut Kisakol, Gurcan aut Enthalten in BMC endocrine disorders [S.l.] : BioMed Central, 2001 15(2015), 1 vom: 20. Juni (DE-627)355456575 (DE-600)2091323-0 1472-6823 nnns volume:15 year:2015 number:1 day:20 month:06 https://dx.doi.org/10.1186/s12902-015-0025-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 06
allfieldsSound	10.1186/s12902-015-0025-2 doi (DE-627)SPR028699610 (SPR)s12902-015-0025-2-e DE-627 ger DE-627 rakwb eng Guclu, Metin verfasserin aut Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Guclu et al. 2015 Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213 Cander, Soner aut Kiyici, Sinem aut Vatansever, Ebru aut Hacihasanoğlu, Arif Bayram aut Kisakol, Gurcan aut Enthalten in BMC endocrine disorders [S.l.] : BioMed Central, 2001 15(2015), 1 vom: 20. Juni (DE-627)355456575 (DE-600)2091323-0 1472-6823 nnns volume:15 year:2015 number:1 day:20 month:06 https://dx.doi.org/10.1186/s12902-015-0025-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2015 1 20 06
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source	Enthalten in BMC endocrine disorders 15(2015), 1 vom: 20. Juni volume:15 year:2015 number:1 day:20 month:06
sourceStr	Enthalten in BMC endocrine disorders 15(2015), 1 vom: 20. Juni volume:15 year:2015 number:1 day:20 month:06
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topic_facet	Pregnancy Prolactin Macroprolactin Thyroid dysfunction Thyroid autoimmunity
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authorswithroles_txt_mv	Guclu, Metin @@aut@@ Cander, Soner @@aut@@ Kiyici, Sinem @@aut@@ Vatansever, Ebru @@aut@@ Hacihasanoğlu, Arif Bayram @@aut@@ Kisakol, Gurcan @@aut@@
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author	Guclu, Metin
spellingShingle	Guclu, Metin misc Pregnancy misc Prolactin misc Macroprolactin misc Thyroid dysfunction misc Thyroid autoimmunity Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
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topic_title	Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity Pregnancy (dpeaa)DE-He213 Prolactin (dpeaa)DE-He213 Macroprolactin (dpeaa)DE-He213 Thyroid dysfunction (dpeaa)DE-He213 Thyroid autoimmunity (dpeaa)DE-He213
topic	misc Pregnancy misc Prolactin misc Macroprolactin misc Thyroid dysfunction misc Thyroid autoimmunity
topic_unstemmed	misc Pregnancy misc Prolactin misc Macroprolactin misc Thyroid dysfunction misc Thyroid autoimmunity
topic_browse	misc Pregnancy misc Prolactin misc Macroprolactin misc Thyroid dysfunction misc Thyroid autoimmunity
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title	Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
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title_full	Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
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author_browse	Guclu, Metin Cander, Soner Kiyici, Sinem Vatansever, Ebru Hacihasanoğlu, Arif Bayram Kisakol, Gurcan
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title_sort	serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
title_auth	Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
abstract	Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. © Guclu et al. 2015
abstractGer	Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. © Guclu et al. 2015
abstract_unstemmed	Bacground To assess the contribution of macroprolactin to high serum prolactin levels and their association with thyroid status and thyroid autoimmunity during pregnancy. Methods 138 pregnant women who suspected of having thyroid dysfunction were studied and divided into three groups according to the thyroid status; group 1; euthyroidism (n 40), group 2; hypothyroidism (n 54), and group 3; hyperthyroid (n 44). Polyethylene glycol (PEG) precipitation method was used for detection of macroprolactin. A percentage recovery of 40 % or less is considered as macroprolactinemia. If macroprolactin was negative, the percentage of monomeric prolactin recovery (monoPRL %) after PEG precipitation was used for comparison between the groups. Results Macroprolactinemia was found in two patients (1.4 %) one from hypothyroid and other from euthyroid group. Basal prolactin levels in these patients were 400 and 403 ng/mL respectively. Referring to all patients, there was no correlation between PRL, macroPRL or monoPRL % with thyroid hormone status and also with the serum levels of thyroid antibodies (p > 0.05). A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. These results confirmed that measured prolactin was quite homogeneous during pregnancy. © Guclu et al. 2015
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title_short	Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity
url	https://dx.doi.org/10.1186/s12902-015-0025-2
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author2	Cander, Soner Kiyici, Sinem Vatansever, Ebru Hacihasanoğlu, Arif Bayram Kisakol, Gurcan
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up_date	2024-07-03T21:10:01.893Z
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A positive correlation was observed between the serum levels of PRL with TSH (p = 0.014 and r = 0.219), while a negative correlation was found with FT4 (p = 0.011 and r = −0.227). Conclusions Despite the fact that serum prolactin levels were found to be high during pregnancy, the contribution of macroprolactin was found to be insignificant in our study. Unlike other auto immune diseases, we could not find any relationship between thyroid autoimmunity and PRL, macroPRL or monoPRL %. 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Serum macroprolactin levels in pregnancy and association with thyroid autoimmunity

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