Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake o...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Gaiser, Birgit K [verfasserIn] Fernandes, Teresa F Jepson, Mark Lead, Jamie R Tyler, Charles R Stone, Vicki

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Silver Particle Human Intestinal Epithelial Cell CeO2 Particle Nanotechnology Industry Human Intestinal Epithelial Cell Line

Anmerkung:	© Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Environmental health - London : BioMed Central, 2002, 8(2009), Suppl 1 vom: 21. Dez.
Übergeordnetes Werk:	volume:8 ; year:2009 ; number:Suppl 1 ; day:21 ; month:12

Links:	Volltext

DOI / URN:	10.1186/1476-069X-8-S1-S2

Katalog-ID:	SPR028722221

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allfields	10.1186/1476-069X-8-S1-S2 doi (DE-627)SPR028722221 (SPR)1476-069X-8-S1-S2-e DE-627 ger DE-627 rakwb eng Gaiser, Birgit K verfasserin aut Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213 Fernandes, Teresa F aut Jepson, Mark aut Lead, Jamie R aut Tyler, Charles R aut Stone, Vicki aut Enthalten in Environmental health London : BioMed Central, 2002 8(2009), Suppl 1 vom: 21. Dez. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:8 year:2009 number:Suppl 1 day:21 month:12 https://dx.doi.org/10.1186/1476-069X-8-S1-S2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2009 Suppl 1 21 12
spelling	10.1186/1476-069X-8-S1-S2 doi (DE-627)SPR028722221 (SPR)1476-069X-8-S1-S2-e DE-627 ger DE-627 rakwb eng Gaiser, Birgit K verfasserin aut Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213 Fernandes, Teresa F aut Jepson, Mark aut Lead, Jamie R aut Tyler, Charles R aut Stone, Vicki aut Enthalten in Environmental health London : BioMed Central, 2002 8(2009), Suppl 1 vom: 21. Dez. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:8 year:2009 number:Suppl 1 day:21 month:12 https://dx.doi.org/10.1186/1476-069X-8-S1-S2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2009 Suppl 1 21 12
allfields_unstemmed	10.1186/1476-069X-8-S1-S2 doi (DE-627)SPR028722221 (SPR)1476-069X-8-S1-S2-e DE-627 ger DE-627 rakwb eng Gaiser, Birgit K verfasserin aut Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213 Fernandes, Teresa F aut Jepson, Mark aut Lead, Jamie R aut Tyler, Charles R aut Stone, Vicki aut Enthalten in Environmental health London : BioMed Central, 2002 8(2009), Suppl 1 vom: 21. Dez. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:8 year:2009 number:Suppl 1 day:21 month:12 https://dx.doi.org/10.1186/1476-069X-8-S1-S2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2009 Suppl 1 21 12
allfieldsGer	10.1186/1476-069X-8-S1-S2 doi (DE-627)SPR028722221 (SPR)1476-069X-8-S1-S2-e DE-627 ger DE-627 rakwb eng Gaiser, Birgit K verfasserin aut Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213 Fernandes, Teresa F aut Jepson, Mark aut Lead, Jamie R aut Tyler, Charles R aut Stone, Vicki aut Enthalten in Environmental health London : BioMed Central, 2002 8(2009), Suppl 1 vom: 21. Dez. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:8 year:2009 number:Suppl 1 day:21 month:12 https://dx.doi.org/10.1186/1476-069X-8-S1-S2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2009 Suppl 1 21 12
allfieldsSound	10.1186/1476-069X-8-S1-S2 doi (DE-627)SPR028722221 (SPR)1476-069X-8-S1-S2-e DE-627 ger DE-627 rakwb eng Gaiser, Birgit K verfasserin aut Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213 Fernandes, Teresa F aut Jepson, Mark aut Lead, Jamie R aut Tyler, Charles R aut Stone, Vicki aut Enthalten in Environmental health London : BioMed Central, 2002 8(2009), Suppl 1 vom: 21. Dez. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:8 year:2009 number:Suppl 1 day:21 month:12 https://dx.doi.org/10.1186/1476-069X-8-S1-S2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2009 Suppl 1 21 12
language	English
source	Enthalten in Environmental health 8(2009), Suppl 1 vom: 21. Dez. volume:8 year:2009 number:Suppl 1 day:21 month:12
sourceStr	Enthalten in Environmental health 8(2009), Suppl 1 vom: 21. Dez. volume:8 year:2009 number:Suppl 1 day:21 month:12
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author	Gaiser, Birgit K
spellingShingle	Gaiser, Birgit K misc Silver Particle misc Human Intestinal Epithelial Cell misc CeO2 Particle misc Nanotechnology Industry misc Human Intestinal Epithelial Cell Line Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
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topic_title	Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments Silver Particle (dpeaa)DE-He213 Human Intestinal Epithelial Cell (dpeaa)DE-He213 CeO2 Particle (dpeaa)DE-He213 Nanotechnology Industry (dpeaa)DE-He213 Human Intestinal Epithelial Cell Line (dpeaa)DE-He213
topic	misc Silver Particle misc Human Intestinal Epithelial Cell misc CeO2 Particle misc Nanotechnology Industry misc Human Intestinal Epithelial Cell Line
topic_unstemmed	misc Silver Particle misc Human Intestinal Epithelial Cell misc CeO2 Particle misc Nanotechnology Industry misc Human Intestinal Epithelial Cell Line
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title_full	Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
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title_sort	assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
title_auth	Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
abstract	Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species. © Gaiser et al; licensee BioMed Central Ltd. 2009. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
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This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and $ CeO_{2} $ particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano $ CeO_{2} $ = micro $ CeO_{2} $. Such consistency suggests that further studies might allow extrapolation of results between different models and species.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Silver Particle</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Intestinal Epithelial Cell</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CeO2 Particle</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanotechnology Industry</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Intestinal Epithelial Cell Line</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fernandes, Teresa F</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jepson, Mark</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lead, Jamie R</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tyler, Charles R</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stone, Vicki</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Environmental health</subfield><subfield code="d">London : BioMed Central, 2002</subfield><subfield code="g">8(2009), Suppl 1 vom: 21. 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Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

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