Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib
Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wicherts, Dennis A [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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| Übergeordnetes Werk: |
Enthalten in: World journal of surgical oncology - London : Biomed Central, 2003, 11(2013), 1 vom: 08. März |
|---|---|
| Übergeordnetes Werk: |
volume:11 ; year:2013 ; number:1 ; day:08 ; month:03 |
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10.1186/1477-7819-11-59 |
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| 520 | |a Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. | ||
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10.1186/1477-7819-11-59 doi (DE-627)SPR028822196 (SPR)1477-7819-11-59-e DE-627 ger DE-627 rakwb eng Wicherts, Dennis A verfasserin aut Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. Dermatofibrosarcoma protuberans (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 van Coevorden, Frits aut Klomp, Houke M aut van Huizum, Martine A aut Kerst, J Martijn aut Haas, Rick LM aut van Boven, Hester H aut van der Hage, JA aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 11(2013), 1 vom: 08. März (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:11 year:2013 number:1 day:08 month:03 https://dx.doi.org/10.1186/1477-7819-11-59 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 1 08 03 |
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10.1186/1477-7819-11-59 doi (DE-627)SPR028822196 (SPR)1477-7819-11-59-e DE-627 ger DE-627 rakwb eng Wicherts, Dennis A verfasserin aut Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. Dermatofibrosarcoma protuberans (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 van Coevorden, Frits aut Klomp, Houke M aut van Huizum, Martine A aut Kerst, J Martijn aut Haas, Rick LM aut van Boven, Hester H aut van der Hage, JA aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 11(2013), 1 vom: 08. März (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:11 year:2013 number:1 day:08 month:03 https://dx.doi.org/10.1186/1477-7819-11-59 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 1 08 03 |
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10.1186/1477-7819-11-59 doi (DE-627)SPR028822196 (SPR)1477-7819-11-59-e DE-627 ger DE-627 rakwb eng Wicherts, Dennis A verfasserin aut Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. Dermatofibrosarcoma protuberans (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 van Coevorden, Frits aut Klomp, Houke M aut van Huizum, Martine A aut Kerst, J Martijn aut Haas, Rick LM aut van Boven, Hester H aut van der Hage, JA aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 11(2013), 1 vom: 08. März (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:11 year:2013 number:1 day:08 month:03 https://dx.doi.org/10.1186/1477-7819-11-59 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 1 08 03 |
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10.1186/1477-7819-11-59 doi (DE-627)SPR028822196 (SPR)1477-7819-11-59-e DE-627 ger DE-627 rakwb eng Wicherts, Dennis A verfasserin aut Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. Dermatofibrosarcoma protuberans (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 van Coevorden, Frits aut Klomp, Houke M aut van Huizum, Martine A aut Kerst, J Martijn aut Haas, Rick LM aut van Boven, Hester H aut van der Hage, JA aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 11(2013), 1 vom: 08. März (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:11 year:2013 number:1 day:08 month:03 https://dx.doi.org/10.1186/1477-7819-11-59 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 1 08 03 |
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10.1186/1477-7819-11-59 doi (DE-627)SPR028822196 (SPR)1477-7819-11-59-e DE-627 ger DE-627 rakwb eng Wicherts, Dennis A verfasserin aut Complete resection of recurrent and initially unresectable dermatofibrosarcoma protuberans downsized by Imatinib 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. Dermatofibrosarcoma protuberans (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 van Coevorden, Frits aut Klomp, Houke M aut van Huizum, Martine A aut Kerst, J Martijn aut Haas, Rick LM aut van Boven, Hester H aut van der Hage, JA aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 11(2013), 1 vom: 08. März (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:11 year:2013 number:1 day:08 month:03 https://dx.doi.org/10.1186/1477-7819-11-59 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2013 1 08 03 |
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Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Abstract Curative surgical treatment of recurrent, locally advanced dermatofibrosarcoma protuberans is often limited owing to a close relation of the tumor with important anatomical structures. Targeted therapy with imatinib, a tyrosine kinase inhibitor, may cause significant reduction of tumor volume, thereby enabling radical surgery. This treatment strategy, therefore, offers a chance of cure for selected patients with advanced dermatofibrosarcoma protuberans. In addition, preoperative treatment with imatinib may decrease possible disfigurement related to radical surgery for large tumors. © Wicherts et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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7.4001703 |