Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer

Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate th...
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Autor*in:	Tominaga, Tetsuro [verfasserIn] Nonaka, Takashi Sumida, Yorihisa Hidaka, Shigekazu Sawai, Terumitsu Nagayasu, Takeshi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Adjuvant chemotherapy Colorectal cancer Elderly patients

Anmerkung:	© The Author(s). 2016

Übergeordnetes Werk:	Enthalten in: World journal of surgical oncology - London : Biomed Central, 2003, 14(2016), 1 vom: 28. Juli
Übergeordnetes Werk:	volume:14 ; year:2016 ; number:1 ; day:28 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12957-016-0959-5

Katalog-ID:	SPR028836375

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520			\|a Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age.
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allfields	10.1186/s12957-016-0959-5 doi (DE-627)SPR028836375 (SPR)s12957-016-0959-5-e DE-627 ger DE-627 rakwb eng Tominaga, Tetsuro verfasserin (orcid)0000-0001-9429-3227 aut Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Nonaka, Takashi aut Sumida, Yorihisa aut Hidaka, Shigekazu aut Sawai, Terumitsu aut Nagayasu, Takeshi aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 14(2016), 1 vom: 28. Juli (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:14 year:2016 number:1 day:28 month:07 https://dx.doi.org/10.1186/s12957-016-0959-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 28 07
spelling	10.1186/s12957-016-0959-5 doi (DE-627)SPR028836375 (SPR)s12957-016-0959-5-e DE-627 ger DE-627 rakwb eng Tominaga, Tetsuro verfasserin (orcid)0000-0001-9429-3227 aut Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Nonaka, Takashi aut Sumida, Yorihisa aut Hidaka, Shigekazu aut Sawai, Terumitsu aut Nagayasu, Takeshi aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 14(2016), 1 vom: 28. Juli (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:14 year:2016 number:1 day:28 month:07 https://dx.doi.org/10.1186/s12957-016-0959-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 28 07
allfields_unstemmed	10.1186/s12957-016-0959-5 doi (DE-627)SPR028836375 (SPR)s12957-016-0959-5-e DE-627 ger DE-627 rakwb eng Tominaga, Tetsuro verfasserin (orcid)0000-0001-9429-3227 aut Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Nonaka, Takashi aut Sumida, Yorihisa aut Hidaka, Shigekazu aut Sawai, Terumitsu aut Nagayasu, Takeshi aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 14(2016), 1 vom: 28. Juli (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:14 year:2016 number:1 day:28 month:07 https://dx.doi.org/10.1186/s12957-016-0959-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 28 07
allfieldsGer	10.1186/s12957-016-0959-5 doi (DE-627)SPR028836375 (SPR)s12957-016-0959-5-e DE-627 ger DE-627 rakwb eng Tominaga, Tetsuro verfasserin (orcid)0000-0001-9429-3227 aut Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Nonaka, Takashi aut Sumida, Yorihisa aut Hidaka, Shigekazu aut Sawai, Terumitsu aut Nagayasu, Takeshi aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 14(2016), 1 vom: 28. Juli (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:14 year:2016 number:1 day:28 month:07 https://dx.doi.org/10.1186/s12957-016-0959-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 28 07
allfieldsSound	10.1186/s12957-016-0959-5 doi (DE-627)SPR028836375 (SPR)s12957-016-0959-5-e DE-627 ger DE-627 rakwb eng Tominaga, Tetsuro verfasserin (orcid)0000-0001-9429-3227 aut Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213 Nonaka, Takashi aut Sumida, Yorihisa aut Hidaka, Shigekazu aut Sawai, Terumitsu aut Nagayasu, Takeshi aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 14(2016), 1 vom: 28. Juli (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:14 year:2016 number:1 day:28 month:07 https://dx.doi.org/10.1186/s12957-016-0959-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 28 07
language	English
source	Enthalten in World journal of surgical oncology 14(2016), 1 vom: 28. Juli volume:14 year:2016 number:1 day:28 month:07
sourceStr	Enthalten in World journal of surgical oncology 14(2016), 1 vom: 28. Juli volume:14 year:2016 number:1 day:28 month:07
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institution	findex.gbv.de
topic_facet	Adjuvant chemotherapy Colorectal cancer Elderly patients
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container_title	World journal of surgical oncology
authorswithroles_txt_mv	Tominaga, Tetsuro @@aut@@ Nonaka, Takashi @@aut@@ Sumida, Yorihisa @@aut@@ Hidaka, Shigekazu @@aut@@ Sawai, Terumitsu @@aut@@ Nagayasu, Takeshi @@aut@@
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However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). 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author	Tominaga, Tetsuro
spellingShingle	Tominaga, Tetsuro misc Adjuvant chemotherapy misc Colorectal cancer misc Elderly patients Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
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topic_title	Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer Adjuvant chemotherapy (dpeaa)DE-He213 Colorectal cancer (dpeaa)DE-He213 Elderly patients (dpeaa)DE-He213
topic	misc Adjuvant chemotherapy misc Colorectal cancer misc Elderly patients
topic_unstemmed	misc Adjuvant chemotherapy misc Colorectal cancer misc Elderly patients
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title	Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
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title_full	Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
author_sort	Tominaga, Tetsuro
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author_browse	Tominaga, Tetsuro Nonaka, Takashi Sumida, Yorihisa Hidaka, Shigekazu Sawai, Terumitsu Nagayasu, Takeshi
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title_sort	effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
title_auth	Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
abstract	Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. © The Author(s). 2016
abstractGer	Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. © The Author(s). 2016
abstract_unstemmed	Background Several guidelines state that postoperative adjuvant chemotherapy (AC) confers survival benefits to patients with lymph node-positive colorectal cancer. However, older patients are usually not administered AC due to the higher risk of side effects. The aim of this study was to evaluate the benefit of AC for elderly patients (EP) and examine its tolerability. Methods Data from 204 patients with lymph node-positive colon cancer were retrospectively analyzed. Patients were subdivided into two groups: EP, >75 years old (n = 53) and young patients (YP), <75 years old (n = 151). Clinicopathological features, type of chemotherapy, and outcomes were compared between groups. Results Frequency of comorbidities and performance status were significantly higher in EP (p < 0.01 each), a greater proportion of YP (76 %) than EP received AC (40 %, p < 0.01), and YP received combination therapy more frequently than EP (p < 0.01). In terms of side effects, few EP showed severe side effects. Both YP and EP gained survival benefits from AC (p = 0.07 and p < 0.01, respectively). Conclusions AC should not be withheld from eligible EP purely because of age. © The Author(s). 2016
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title_short	Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer
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author2	Nonaka, Takashi Sumida, Yorihisa Hidaka, Shigekazu Sawai, Terumitsu Nagayasu, Takeshi
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Effectiveness of adjuvant chemotherapy for elderly patients with lymph node-positive colorectal cancer

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