Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer

Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder c...
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Autor*in:	Maruyama, Suguru [verfasserIn] Kawaida, Hiromichi Hosomura, Naohiro Amemiya, Hidetake Saito, Ryo Shimizu, Hiroki Furuya, Shinji Akaike, Hidenori Kawaguchi, Yoshihiko Sudo, Makoto Inoue, Shingo Kono, Hiroshi Ichikawa, Daisuke

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Gallbladder cancer Perineural invasion Extrahepatic bile duct resection

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: World journal of surgical oncology - London : Biomed Central, 2003, 17(2019), 1 vom: 30. Nov.
Übergeordnetes Werk:	volume:17 ; year:2019 ; number:1 ; day:30 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12957-019-1735-0

Katalog-ID:	SPR028844211

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520			\|a Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI.
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allfields	10.1186/s12957-019-1735-0 doi (DE-627)SPR028844211 (SPR)s12957-019-1735-0-e DE-627 ger DE-627 rakwb eng Maruyama, Suguru verfasserin aut Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213 Kawaida, Hiromichi aut Hosomura, Naohiro aut Amemiya, Hidetake aut Saito, Ryo aut Shimizu, Hiroki aut Furuya, Shinji aut Akaike, Hidenori aut Kawaguchi, Yoshihiko aut Sudo, Makoto aut Inoue, Shingo aut Kono, Hiroshi aut Ichikawa, Daisuke aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 17(2019), 1 vom: 30. Nov. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:17 year:2019 number:1 day:30 month:11 https://dx.doi.org/10.1186/s12957-019-1735-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 30 11
spelling	10.1186/s12957-019-1735-0 doi (DE-627)SPR028844211 (SPR)s12957-019-1735-0-e DE-627 ger DE-627 rakwb eng Maruyama, Suguru verfasserin aut Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213 Kawaida, Hiromichi aut Hosomura, Naohiro aut Amemiya, Hidetake aut Saito, Ryo aut Shimizu, Hiroki aut Furuya, Shinji aut Akaike, Hidenori aut Kawaguchi, Yoshihiko aut Sudo, Makoto aut Inoue, Shingo aut Kono, Hiroshi aut Ichikawa, Daisuke aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 17(2019), 1 vom: 30. Nov. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:17 year:2019 number:1 day:30 month:11 https://dx.doi.org/10.1186/s12957-019-1735-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 30 11
allfields_unstemmed	10.1186/s12957-019-1735-0 doi (DE-627)SPR028844211 (SPR)s12957-019-1735-0-e DE-627 ger DE-627 rakwb eng Maruyama, Suguru verfasserin aut Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213 Kawaida, Hiromichi aut Hosomura, Naohiro aut Amemiya, Hidetake aut Saito, Ryo aut Shimizu, Hiroki aut Furuya, Shinji aut Akaike, Hidenori aut Kawaguchi, Yoshihiko aut Sudo, Makoto aut Inoue, Shingo aut Kono, Hiroshi aut Ichikawa, Daisuke aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 17(2019), 1 vom: 30. Nov. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:17 year:2019 number:1 day:30 month:11 https://dx.doi.org/10.1186/s12957-019-1735-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 30 11
allfieldsGer	10.1186/s12957-019-1735-0 doi (DE-627)SPR028844211 (SPR)s12957-019-1735-0-e DE-627 ger DE-627 rakwb eng Maruyama, Suguru verfasserin aut Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213 Kawaida, Hiromichi aut Hosomura, Naohiro aut Amemiya, Hidetake aut Saito, Ryo aut Shimizu, Hiroki aut Furuya, Shinji aut Akaike, Hidenori aut Kawaguchi, Yoshihiko aut Sudo, Makoto aut Inoue, Shingo aut Kono, Hiroshi aut Ichikawa, Daisuke aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 17(2019), 1 vom: 30. Nov. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:17 year:2019 number:1 day:30 month:11 https://dx.doi.org/10.1186/s12957-019-1735-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 30 11
allfieldsSound	10.1186/s12957-019-1735-0 doi (DE-627)SPR028844211 (SPR)s12957-019-1735-0-e DE-627 ger DE-627 rakwb eng Maruyama, Suguru verfasserin aut Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213 Kawaida, Hiromichi aut Hosomura, Naohiro aut Amemiya, Hidetake aut Saito, Ryo aut Shimizu, Hiroki aut Furuya, Shinji aut Akaike, Hidenori aut Kawaguchi, Yoshihiko aut Sudo, Makoto aut Inoue, Shingo aut Kono, Hiroshi aut Ichikawa, Daisuke aut Enthalten in World journal of surgical oncology London : Biomed Central, 2003 17(2019), 1 vom: 30. Nov. (DE-627)369082907 (DE-600)2118383-1 1477-7819 nnns volume:17 year:2019 number:1 day:30 month:11 https://dx.doi.org/10.1186/s12957-019-1735-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 30 11
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source	Enthalten in World journal of surgical oncology 17(2019), 1 vom: 30. Nov. volume:17 year:2019 number:1 day:30 month:11
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On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. 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author	Maruyama, Suguru
spellingShingle	Maruyama, Suguru misc Gallbladder cancer misc Perineural invasion misc Extrahepatic bile duct resection Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
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topic_title	Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer Gallbladder cancer (dpeaa)DE-He213 Perineural invasion (dpeaa)DE-He213 Extrahepatic bile duct resection (dpeaa)DE-He213
topic	misc Gallbladder cancer misc Perineural invasion misc Extrahepatic bile duct resection
topic_unstemmed	misc Gallbladder cancer misc Perineural invasion misc Extrahepatic bile duct resection
topic_browse	misc Gallbladder cancer misc Perineural invasion misc Extrahepatic bile duct resection
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title	Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
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title_full	Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
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author_browse	Maruyama, Suguru Kawaida, Hiromichi Hosomura, Naohiro Amemiya, Hidetake Saito, Ryo Shimizu, Hiroki Furuya, Shinji Akaike, Hidenori Kawaguchi, Yoshihiko Sudo, Makoto Inoue, Shingo Kono, Hiroshi Ichikawa, Daisuke
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title_sort	indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
title_auth	Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
abstract	Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. © The Author(s). 2019
abstractGer	Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. © The Author(s). 2019
abstract_unstemmed	Background The indications for extrahepatic bile duct (EHBD) resection remain a major controversy in the surgical management of patients with gallbladder cancer. On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. We suggest that EHBD resection in combination with cholecystectomy may not be useful for distal-type tumors from a perspective of PNI. © The Author(s). 2019
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title_short	Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
url	https://dx.doi.org/10.1186/s12957-019-1735-0
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author2	Kawaida, Hiromichi Hosomura, Naohiro Amemiya, Hidetake Saito, Ryo Shimizu, Hiroki Furuya, Shinji Akaike, Hidenori Kawaguchi, Yoshihiko Sudo, Makoto Inoue, Shingo Kono, Hiroshi Ichikawa, Daisuke
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up_date	2024-07-03T22:04:10.457Z
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On the other hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via perineural routes. We assessed the correlation of PNI with clinicopathological factors in patients with gallbladder cancer to elucidate EHBD resection indications specifically in patients with PNI. Methods This retrospective study assessed the PNI status of 50 patients with gallbladder cancer who underwent curative resection and examined the correlation between the presence of PNI and clinicopathological factors. Results Thirteen patients (26%) were PNI positive. PNI was significantly correlated with male sex, proximal-type tumor, lymphatic and vascular invasion, and advanced T stage. Multivariate analysis found that PNI positivity (p < 0.001), lymphatic invasion (p = 0.007), and nodal stage (p < 0.001) were independent prognostic factors. PNI was never observed in patients with stage T1 cancer. Conversely, PNI was detected rarely in distal-type tumors, all of whom developed various types of recurrences. Conclusions These results clearly demonstrated the prognostic impact of PNI in patients with gallbladder cancer. 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Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer

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