Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia

Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and...
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Autor*in:	Ishida, Kosei [verfasserIn] Ito, Satoshi Wada, Naoyuki Deguchi, Hiroyo Hata, Tsuyoshi Hosoda, Masaru Nohno, Tsutomu

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Nuclear Expression Epithelial Dysplasia Oral Leukoplakia Atypical Epithelium Mild Dysplasia

Anmerkung:	© Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Molecular cancer - London : Biomed Central, 2002, 6(2007), 1 vom: 09. Okt.
Übergeordnetes Werk:	volume:6 ; year:2007 ; number:1 ; day:09 ; month:10

Links:	Volltext

DOI / URN:	10.1186/1476-4598-6-62

Katalog-ID:	SPR028881567

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520			\|a Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia.
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author_variant	k i ki s i si n w nw h d hd t h th m h mh t n tn
matchkey_str	article:14764598:2007----::ulalclztoobtctnnnovdnrcneosh
hierarchy_sort_str	2007
publishDate	2007
allfields	10.1186/1476-4598-6-62 doi (DE-627)SPR028881567 (SPR)1476-4598-6-62-e DE-627 ger DE-627 rakwb eng Ishida, Kosei verfasserin aut Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Ito, Satoshi aut Wada, Naoyuki aut Deguchi, Hiroyo aut Hata, Tsuyoshi aut Hosoda, Masaru aut Nohno, Tsutomu aut Enthalten in Molecular cancer London : Biomed Central, 2002 6(2007), 1 vom: 09. Okt. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:6 year:2007 number:1 day:09 month:10 https://dx.doi.org/10.1186/1476-4598-6-62 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 09 10
spelling	10.1186/1476-4598-6-62 doi (DE-627)SPR028881567 (SPR)1476-4598-6-62-e DE-627 ger DE-627 rakwb eng Ishida, Kosei verfasserin aut Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Ito, Satoshi aut Wada, Naoyuki aut Deguchi, Hiroyo aut Hata, Tsuyoshi aut Hosoda, Masaru aut Nohno, Tsutomu aut Enthalten in Molecular cancer London : Biomed Central, 2002 6(2007), 1 vom: 09. Okt. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:6 year:2007 number:1 day:09 month:10 https://dx.doi.org/10.1186/1476-4598-6-62 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 09 10
allfields_unstemmed	10.1186/1476-4598-6-62 doi (DE-627)SPR028881567 (SPR)1476-4598-6-62-e DE-627 ger DE-627 rakwb eng Ishida, Kosei verfasserin aut Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Ito, Satoshi aut Wada, Naoyuki aut Deguchi, Hiroyo aut Hata, Tsuyoshi aut Hosoda, Masaru aut Nohno, Tsutomu aut Enthalten in Molecular cancer London : Biomed Central, 2002 6(2007), 1 vom: 09. Okt. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:6 year:2007 number:1 day:09 month:10 https://dx.doi.org/10.1186/1476-4598-6-62 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 09 10
allfieldsGer	10.1186/1476-4598-6-62 doi (DE-627)SPR028881567 (SPR)1476-4598-6-62-e DE-627 ger DE-627 rakwb eng Ishida, Kosei verfasserin aut Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Ito, Satoshi aut Wada, Naoyuki aut Deguchi, Hiroyo aut Hata, Tsuyoshi aut Hosoda, Masaru aut Nohno, Tsutomu aut Enthalten in Molecular cancer London : Biomed Central, 2002 6(2007), 1 vom: 09. Okt. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:6 year:2007 number:1 day:09 month:10 https://dx.doi.org/10.1186/1476-4598-6-62 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 09 10
allfieldsSound	10.1186/1476-4598-6-62 doi (DE-627)SPR028881567 (SPR)1476-4598-6-62-e DE-627 ger DE-627 rakwb eng Ishida, Kosei verfasserin aut Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Ito, Satoshi aut Wada, Naoyuki aut Deguchi, Hiroyo aut Hata, Tsuyoshi aut Hosoda, Masaru aut Nohno, Tsutomu aut Enthalten in Molecular cancer London : Biomed Central, 2002 6(2007), 1 vom: 09. Okt. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:6 year:2007 number:1 day:09 month:10 https://dx.doi.org/10.1186/1476-4598-6-62 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2007 1 09 10
language	English
source	Enthalten in Molecular cancer 6(2007), 1 vom: 09. Okt. volume:6 year:2007 number:1 day:09 month:10
sourceStr	Enthalten in Molecular cancer 6(2007), 1 vom: 09. Okt. volume:6 year:2007 number:1 day:09 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Nuclear Expression Epithelial Dysplasia Oral Leukoplakia Atypical Epithelium Mild Dysplasia
isfreeaccess_bool	false
container_title	Molecular cancer
authorswithroles_txt_mv	Ishida, Kosei @@aut@@ Ito, Satoshi @@aut@@ Wada, Naoyuki @@aut@@ Deguchi, Hiroyo @@aut@@ Hata, Tsuyoshi @@aut@@ Hosoda, Masaru @@aut@@ Nohno, Tsutomu @@aut@@
publishDateDaySort_date	2007-10-09T00:00:00Z
hierarchy_top_id	355987619
id	SPR028881567
language_de	englisch
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author	Ishida, Kosei
spellingShingle	Ishida, Kosei misc Nuclear Expression misc Epithelial Dysplasia misc Oral Leukoplakia misc Atypical Epithelium misc Mild Dysplasia Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
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topic_title	Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia Nuclear Expression (dpeaa)DE-He213 Epithelial Dysplasia (dpeaa)DE-He213 Oral Leukoplakia (dpeaa)DE-He213 Atypical Epithelium (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213
topic	misc Nuclear Expression misc Epithelial Dysplasia misc Oral Leukoplakia misc Atypical Epithelium misc Mild Dysplasia
topic_unstemmed	misc Nuclear Expression misc Epithelial Dysplasia misc Oral Leukoplakia misc Atypical Epithelium misc Mild Dysplasia
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title	Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
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title_full	Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
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author_browse	Ishida, Kosei Ito, Satoshi Wada, Naoyuki Deguchi, Hiroyo Hata, Tsuyoshi Hosoda, Masaru Nohno, Tsutomu
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title_sort	nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
title_auth	Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
abstract	Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia. Results The normal oral epithelium showed β-catenin expression only in the cell membrane, but not in the nuclei. In the oral leukoplakia without dysplasia, 7 out of 17 samples (41%) showed β-catenin expression in the cell membrane, and 5 samples (29%) showed expression in the nuclei. In the oral leukoplakia with dysplasia, nuclear expression of β-catenin was shown in 11 out of 12 samples (92%). Incidence of nuclear β-catenin expression was significantly different between dysplasia and normal oral epithelium (P < 0.01), and also between oral leukoplakia with dysplasia and those without dysplasia (P < 0.01). Wnt3 expression was detected in the epithelial cell membrane or cytoplasm in oral leukoplakia where nuclear expression of β-catenin was evident, but not in epithelial cells without nuclear expression of β-catenin. Conclusion The components of canonical Wnt pathway, such as Wnt3, β-catenin, and cyclin D1, were detected, implying that this pathway is potentially involved in the progression of dysplasia in oral leukoplakia. © Ishida et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia
url	https://dx.doi.org/10.1186/1476-4598-6-62
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author2	Ito, Satoshi Wada, Naoyuki Deguchi, Hiroyo Hata, Tsuyoshi Hosoda, Masaru Nohno, Tsutomu
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up_date	2024-07-03T22:17:33.968Z
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Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia

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