Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders

Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr)...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Janbaz, Khalid Hussain [verfasserIn] Akhtar, Tashfeen Saqib, Fatima Imran, Imran Zia-Ul-Haq, Muhammad Jansakul, Chaweeewan De Feo, Vincenzo Moga, Marius

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Lour Spasmolytic activity Bronchodilator activity Vasorelaxant activity

Anmerkung:	© Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Journal of translational medicine - London : BioMed Central, 2003, 13(2015), 1 vom: 30. Apr.
Übergeordnetes Werk:	volume:13 ; year:2015 ; number:1 ; day:30 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s12967-015-0470-8

Katalog-ID:	SPR028955579

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520			\|a Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system.
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650		4	\|a Bronchodilator activity \|7 (dpeaa)DE-He213
650		4	\|a Vasorelaxant activity \|7 (dpeaa)DE-He213
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700	1		\|a Moga, Marius \|4 aut
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912			\|a GBV_ILN_31
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912			\|a GBV_ILN_60
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912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
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allfields	10.1186/s12967-015-0470-8 doi (DE-627)SPR028955579 (SPR)s12967-015-0470-8-e DE-627 ger DE-627 rakwb eng Janbaz, Khalid Hussain verfasserin aut Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213 Akhtar, Tashfeen aut Saqib, Fatima aut Imran, Imran aut Zia-Ul-Haq, Muhammad aut Jansakul, Chaweeewan aut De Feo, Vincenzo aut Moga, Marius aut Enthalten in Journal of translational medicine London : BioMed Central, 2003 13(2015), 1 vom: 30. Apr. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:13 year:2015 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12967-015-0470-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 30 04
spelling	10.1186/s12967-015-0470-8 doi (DE-627)SPR028955579 (SPR)s12967-015-0470-8-e DE-627 ger DE-627 rakwb eng Janbaz, Khalid Hussain verfasserin aut Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213 Akhtar, Tashfeen aut Saqib, Fatima aut Imran, Imran aut Zia-Ul-Haq, Muhammad aut Jansakul, Chaweeewan aut De Feo, Vincenzo aut Moga, Marius aut Enthalten in Journal of translational medicine London : BioMed Central, 2003 13(2015), 1 vom: 30. Apr. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:13 year:2015 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12967-015-0470-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 30 04
allfields_unstemmed	10.1186/s12967-015-0470-8 doi (DE-627)SPR028955579 (SPR)s12967-015-0470-8-e DE-627 ger DE-627 rakwb eng Janbaz, Khalid Hussain verfasserin aut Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213 Akhtar, Tashfeen aut Saqib, Fatima aut Imran, Imran aut Zia-Ul-Haq, Muhammad aut Jansakul, Chaweeewan aut De Feo, Vincenzo aut Moga, Marius aut Enthalten in Journal of translational medicine London : BioMed Central, 2003 13(2015), 1 vom: 30. Apr. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:13 year:2015 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12967-015-0470-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 30 04
allfieldsGer	10.1186/s12967-015-0470-8 doi (DE-627)SPR028955579 (SPR)s12967-015-0470-8-e DE-627 ger DE-627 rakwb eng Janbaz, Khalid Hussain verfasserin aut Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213 Akhtar, Tashfeen aut Saqib, Fatima aut Imran, Imran aut Zia-Ul-Haq, Muhammad aut Jansakul, Chaweeewan aut De Feo, Vincenzo aut Moga, Marius aut Enthalten in Journal of translational medicine London : BioMed Central, 2003 13(2015), 1 vom: 30. Apr. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:13 year:2015 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12967-015-0470-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 30 04
allfieldsSound	10.1186/s12967-015-0470-8 doi (DE-627)SPR028955579 (SPR)s12967-015-0470-8-e DE-627 ger DE-627 rakwb eng Janbaz, Khalid Hussain verfasserin aut Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213 Akhtar, Tashfeen aut Saqib, Fatima aut Imran, Imran aut Zia-Ul-Haq, Muhammad aut Jansakul, Chaweeewan aut De Feo, Vincenzo aut Moga, Marius aut Enthalten in Journal of translational medicine London : BioMed Central, 2003 13(2015), 1 vom: 30. Apr. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:13 year:2015 number:1 day:30 month:04 https://dx.doi.org/10.1186/s12967-015-0470-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 30 04
language	English
source	Enthalten in Journal of translational medicine 13(2015), 1 vom: 30. Apr. volume:13 year:2015 number:1 day:30 month:04
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. 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author	Janbaz, Khalid Hussain
spellingShingle	Janbaz, Khalid Hussain misc Lour misc Spasmolytic activity misc Bronchodilator activity misc Vasorelaxant activity Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders
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topic_title	Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders Lour (dpeaa)DE-He213 Spasmolytic activity (dpeaa)DE-He213 Bronchodilator activity (dpeaa)DE-He213 Vasorelaxant activity (dpeaa)DE-He213
topic	misc Lour misc Spasmolytic activity misc Bronchodilator activity misc Vasorelaxant activity
topic_unstemmed	misc Lour misc Spasmolytic activity misc Bronchodilator activity misc Vasorelaxant activity
topic_browse	misc Lour misc Spasmolytic activity misc Bronchodilator activity misc Vasorelaxant activity
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title	Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders
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title_full	Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders
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title_sort	pharmacological justification of use of solena heterophylla lour. in gastrointestinal, respiratory and vascular disorders
title_auth	Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders
abstract	Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system. © Janbaz et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders
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author2	Akhtar, Tashfeen Saqib, Fatima Imran, Imran Zia-Ul-Haq, Muhammad Jansakul, Chaweeewan De Feo, Vincenzo Moga, Marius
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system and present study was undertaken to validate its traditional uses. Methods The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) was tested in-vitro on isolated rabbit jejunum, tracheal and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. Results The aqueous ethanolic extract of Solena heterophylla Lour (Sh.Cr) (0.03-1.0 mg/ml) on application to spontaneous contractions in isolated rabbit jejunum preparation exerted relaxant effect through decrease in magnitude and frequency of contractions, caused relaxation of $ K^{+} $(80 mM)-induced contractions and shifted the $ Ca^{2+} $ concentration response curves toward right in isolated rabbit jejunum preparations in a manner similar to verapamil (a standard $ Ca^{2+} $ channel blocker), thus confirming its $ Ca^{2+} $ channel blocking activity. The Sh.Cr also caused relaxation of carbachol (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit tracheal preparations in a manner comparable to dicyclomine. Conclusions The observed relaxant effect may be outcome of anti-muscarinic and $ Ca^{2+} $ channel blocking activities. The Sh.Cr (0.03-1.0 mg/ml) against phenyephrine (1 μM)- and $ K^{+} $(80 mM)-induced contractions in isolated rabbit aortic preparations exerted a relaxant effect, possibly through $ Ca^{2+} $ channel blocking activity. These findings provide a rationale for the folkloric uses of the plant in the management of ailments pertaining to gastrointestinal, respiratory and vascular system.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lour</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Spasmolytic activity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bronchodilator activity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vasorelaxant activity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Akhtar, Tashfeen</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Saqib, Fatima</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Imran, Imran</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zia-Ul-Haq, Muhammad</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jansakul, Chaweeewan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">De Feo, Vincenzo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moga, Marius</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of translational medicine</subfield><subfield code="d">London : BioMed Central, 2003</subfield><subfield code="g">13(2015), 1 vom: 30. 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Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders

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