The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)

Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping i...
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Autor*in:	Yi, Colin J [verfasserIn] Wu, Colin O Tee, Michael Liu, Chia-Ying Volpe, Gustavo J Prince, Martin R Hundley, Gregory W Gomes, Antoinette S van der Geest, Rob J Heckbert, Susan Lima, João A Bluemke, David A

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Myocardium Cardiovascular magnetic resonance Risk factors

Anmerkung:	© Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Journal of cardiovascular magnetic resonance - London : BioMed Central, 1999, 17(2015), 1 vom: 12. Feb.
Übergeordnetes Werk:	volume:17 ; year:2015 ; number:1 ; day:12 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12968-015-0121-5

Katalog-ID:	SPR029020999

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100	1		\|a Yi, Colin J \|e verfasserin \|4 aut
245	1	4	\|a The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
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520			\|a Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487.
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700	1		\|a Wu, Colin O \|4 aut
700	1		\|a Tee, Michael \|4 aut
700	1		\|a Liu, Chia-Ying \|4 aut
700	1		\|a Volpe, Gustavo J \|4 aut
700	1		\|a Prince, Martin R \|4 aut
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700	1		\|a Gomes, Antoinette S \|4 aut
700	1		\|a van der Geest, Rob J \|4 aut
700	1		\|a Heckbert, Susan \|4 aut
700	1		\|a Lima, João A \|4 aut
700	1		\|a Bluemke, David A \|4 aut
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allfields	10.1186/s12968-015-0121-5 doi (DE-627)SPR029020999 (SPR)s12968-015-0121-5-e DE-627 ger DE-627 rakwb eng Yi, Colin J verfasserin aut The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Wu, Colin O aut Tee, Michael aut Liu, Chia-Ying aut Volpe, Gustavo J aut Prince, Martin R aut Hundley, Gregory W aut Gomes, Antoinette S aut van der Geest, Rob J aut Heckbert, Susan aut Lima, João A aut Bluemke, David A aut Enthalten in Journal of cardiovascular magnetic resonance London : BioMed Central, 1999 17(2015), 1 vom: 12. Feb. (DE-627)638411602 (DE-600)2578881-4 1532-429X nnns volume:17 year:2015 number:1 day:12 month:02 https://dx.doi.org/10.1186/s12968-015-0121-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2015 1 12 02
spelling	10.1186/s12968-015-0121-5 doi (DE-627)SPR029020999 (SPR)s12968-015-0121-5-e DE-627 ger DE-627 rakwb eng Yi, Colin J verfasserin aut The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Wu, Colin O aut Tee, Michael aut Liu, Chia-Ying aut Volpe, Gustavo J aut Prince, Martin R aut Hundley, Gregory W aut Gomes, Antoinette S aut van der Geest, Rob J aut Heckbert, Susan aut Lima, João A aut Bluemke, David A aut Enthalten in Journal of cardiovascular magnetic resonance London : BioMed Central, 1999 17(2015), 1 vom: 12. Feb. (DE-627)638411602 (DE-600)2578881-4 1532-429X nnns volume:17 year:2015 number:1 day:12 month:02 https://dx.doi.org/10.1186/s12968-015-0121-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2015 1 12 02
allfields_unstemmed	10.1186/s12968-015-0121-5 doi (DE-627)SPR029020999 (SPR)s12968-015-0121-5-e DE-627 ger DE-627 rakwb eng Yi, Colin J verfasserin aut The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Wu, Colin O aut Tee, Michael aut Liu, Chia-Ying aut Volpe, Gustavo J aut Prince, Martin R aut Hundley, Gregory W aut Gomes, Antoinette S aut van der Geest, Rob J aut Heckbert, Susan aut Lima, João A aut Bluemke, David A aut Enthalten in Journal of cardiovascular magnetic resonance London : BioMed Central, 1999 17(2015), 1 vom: 12. Feb. (DE-627)638411602 (DE-600)2578881-4 1532-429X nnns volume:17 year:2015 number:1 day:12 month:02 https://dx.doi.org/10.1186/s12968-015-0121-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2015 1 12 02
allfieldsGer	10.1186/s12968-015-0121-5 doi (DE-627)SPR029020999 (SPR)s12968-015-0121-5-e DE-627 ger DE-627 rakwb eng Yi, Colin J verfasserin aut The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Wu, Colin O aut Tee, Michael aut Liu, Chia-Ying aut Volpe, Gustavo J aut Prince, Martin R aut Hundley, Gregory W aut Gomes, Antoinette S aut van der Geest, Rob J aut Heckbert, Susan aut Lima, João A aut Bluemke, David A aut Enthalten in Journal of cardiovascular magnetic resonance London : BioMed Central, 1999 17(2015), 1 vom: 12. Feb. (DE-627)638411602 (DE-600)2578881-4 1532-429X nnns volume:17 year:2015 number:1 day:12 month:02 https://dx.doi.org/10.1186/s12968-015-0121-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2015 1 12 02
allfieldsSound	10.1186/s12968-015-0121-5 doi (DE-627)SPR029020999 (SPR)s12968-015-0121-5-e DE-627 ger DE-627 rakwb eng Yi, Colin J verfasserin aut The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213 Wu, Colin O aut Tee, Michael aut Liu, Chia-Ying aut Volpe, Gustavo J aut Prince, Martin R aut Hundley, Gregory W aut Gomes, Antoinette S aut van der Geest, Rob J aut Heckbert, Susan aut Lima, João A aut Bluemke, David A aut Enthalten in Journal of cardiovascular magnetic resonance London : BioMed Central, 1999 17(2015), 1 vom: 12. Feb. (DE-627)638411602 (DE-600)2578881-4 1532-429X nnns volume:17 year:2015 number:1 day:12 month:02 https://dx.doi.org/10.1186/s12968-015-0121-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2015 1 12 02
language	English
source	Enthalten in Journal of cardiovascular magnetic resonance 17(2015), 1 vom: 12. Feb. volume:17 year:2015 number:1 day:12 month:02
sourceStr	Enthalten in Journal of cardiovascular magnetic resonance 17(2015), 1 vom: 12. Feb. volume:17 year:2015 number:1 day:12 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Myocardium Cardiovascular magnetic resonance Risk factors
isfreeaccess_bool	false
container_title	Journal of cardiovascular magnetic resonance
authorswithroles_txt_mv	Yi, Colin J @@aut@@ Wu, Colin O @@aut@@ Tee, Michael @@aut@@ Liu, Chia-Ying @@aut@@ Volpe, Gustavo J @@aut@@ Prince, Martin R @@aut@@ Hundley, Gregory W @@aut@@ Gomes, Antoinette S @@aut@@ van der Geest, Rob J @@aut@@ Heckbert, Susan @@aut@@ Lima, João A @@aut@@ Bluemke, David A @@aut@@
publishDateDaySort_date	2015-02-12T00:00:00Z
hierarchy_top_id	638411602
id	SPR029020999
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR029020999</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519150103.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2015 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12968-015-0121-5</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR029020999</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12968-015-0121-5-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Yi, Colin J</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. 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author	Yi, Colin J
spellingShingle	Yi, Colin J misc Myocardium misc Cardiovascular magnetic resonance misc Risk factors The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
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topic_title	The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA) Myocardium (dpeaa)DE-He213 Cardiovascular magnetic resonance (dpeaa)DE-He213 Risk factors (dpeaa)DE-He213
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title	The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
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title_full	The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
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author_browse	Yi, Colin J Wu, Colin O Tee, Michael Liu, Chia-Ying Volpe, Gustavo J Prince, Martin R Hundley, Gregory W Gomes, Antoinette S van der Geest, Rob J Heckbert, Susan Lima, João A Bluemke, David A
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doi_str_mv	10.1186/s12968-015-0121-5
title_sort	association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the multi-ethnic study of atherosclerosis (mesa)
title_auth	The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
abstract	Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. Clinical trial registration http://www.mesa-nhlbi.org/, NCT00005487. © Yi et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)
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author2	Wu, Colin O Tee, Michael Liu, Chia-Ying Volpe, Gustavo J Prince, Martin R Hundley, Gregory W Gomes, Antoinette S van der Geest, Rob J Heckbert, Susan Lima, João A Bluemke, David A
author2Str	Wu, Colin O Tee, Michael Liu, Chia-Ying Volpe, Gustavo J Prince, Martin R Hundley, Gregory W Gomes, Antoinette S van der Geest, Rob J Heckbert, Susan Lima, João A Bluemke, David A
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Risk scores for cardiovascular disease (CVD) are in common use to integrate multiple cardiovascular risk factors in order to identify individuals at greatest risk for disease. The purpose of this study was to determine if individuals at greater cardiovascular risk have $ T_{1} $ mapping indices by cardiovascular magnetic resonance (CMR) indicative of greater myocardial fibrosis. Methods CVD risk scores for 1208 subjects (men, 50.8%) ages 55–94 years old were evaluated in the Multiethnic Study of Atherosclerosis (MESA) at six centers. $ T_{1} $ times were determined at 1.5Tesla before and after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The relationship between CMR measures (native $ T_{1} $, 12 and 25 minute post-gadolinium $ T_{1} $, partition coefficient and extracellular volume fraction) and 14 established different cardiovascular risk scores were determined using regression analysis. Bootstrapping analysis with analysis of variance was used to compare different CMR measures. CVD risk scores were significantly different for men and women (p < 0.001). Results 25 minute post gadolinium $ T_{1} $ time showed more statistically significant associations with risk scores (10/14 scores, 71%) compared to other CMR indices (e.g. native $ T_{1} $ (7/14 scores, 50%) and partition coefficient (7/14, 50%) in men. Risk scores, particularly the new 2013 AHA/ASCVD risk score, did not correlate with any CMR fibrosis index. Conclusions Men with greater CVD risk had greater CMR indices of myocardial fibrosis. $ T_{1} $ times at greater delay time (25 minutes) showed better agreement with commonly used risk score indices compared to ECV and native $ T_{1} $ time. 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The association between cardiovascular risk and cardiovascular magnetic resonance measures of fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)

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