Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies

Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Qureshi-Baig, Komal [verfasserIn] Ullmann, Pit Haan, Serge Letellier, Elisabeth

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Colorectal cancer Cancer stem cells Tumor-initiating cells Culturing conditions Surface markers Spheroid Culture Systems Metabolic identity Targeted therapy Inter- and intra-tumor heterogeneity

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: Molecular cancer - London : Biomed Central, 2002, 16(2017), 1 vom: 16. Feb.
Übergeordnetes Werk:	volume:16 ; year:2017 ; number:1 ; day:16 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12943-017-0602-2

Katalog-ID:	SPR029057310

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allfields	10.1186/s12943-017-0602-2 doi (DE-627)SPR029057310 (SPR)s12943-017-0602-2-e DE-627 ger DE-627 rakwb eng Qureshi-Baig, Komal verfasserin aut Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213 Ullmann, Pit aut Haan, Serge aut Letellier, Elisabeth (orcid)0000-0001-8242-9393 aut Enthalten in Molecular cancer London : Biomed Central, 2002 16(2017), 1 vom: 16. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:16 year:2017 number:1 day:16 month:02 https://dx.doi.org/10.1186/s12943-017-0602-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 16 02
spelling	10.1186/s12943-017-0602-2 doi (DE-627)SPR029057310 (SPR)s12943-017-0602-2-e DE-627 ger DE-627 rakwb eng Qureshi-Baig, Komal verfasserin aut Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213 Ullmann, Pit aut Haan, Serge aut Letellier, Elisabeth (orcid)0000-0001-8242-9393 aut Enthalten in Molecular cancer London : Biomed Central, 2002 16(2017), 1 vom: 16. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:16 year:2017 number:1 day:16 month:02 https://dx.doi.org/10.1186/s12943-017-0602-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 16 02
allfields_unstemmed	10.1186/s12943-017-0602-2 doi (DE-627)SPR029057310 (SPR)s12943-017-0602-2-e DE-627 ger DE-627 rakwb eng Qureshi-Baig, Komal verfasserin aut Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213 Ullmann, Pit aut Haan, Serge aut Letellier, Elisabeth (orcid)0000-0001-8242-9393 aut Enthalten in Molecular cancer London : Biomed Central, 2002 16(2017), 1 vom: 16. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:16 year:2017 number:1 day:16 month:02 https://dx.doi.org/10.1186/s12943-017-0602-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 16 02
allfieldsGer	10.1186/s12943-017-0602-2 doi (DE-627)SPR029057310 (SPR)s12943-017-0602-2-e DE-627 ger DE-627 rakwb eng Qureshi-Baig, Komal verfasserin aut Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213 Ullmann, Pit aut Haan, Serge aut Letellier, Elisabeth (orcid)0000-0001-8242-9393 aut Enthalten in Molecular cancer London : Biomed Central, 2002 16(2017), 1 vom: 16. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:16 year:2017 number:1 day:16 month:02 https://dx.doi.org/10.1186/s12943-017-0602-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 16 02
allfieldsSound	10.1186/s12943-017-0602-2 doi (DE-627)SPR029057310 (SPR)s12943-017-0602-2-e DE-627 ger DE-627 rakwb eng Qureshi-Baig, Komal verfasserin aut Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213 Ullmann, Pit aut Haan, Serge aut Letellier, Elisabeth (orcid)0000-0001-8242-9393 aut Enthalten in Molecular cancer London : Biomed Central, 2002 16(2017), 1 vom: 16. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:16 year:2017 number:1 day:16 month:02 https://dx.doi.org/10.1186/s12943-017-0602-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2017 1 16 02
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source	Enthalten in Molecular cancer 16(2017), 1 vom: 16. Feb. volume:16 year:2017 number:1 day:16 month:02
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author	Qureshi-Baig, Komal
spellingShingle	Qureshi-Baig, Komal misc Colorectal cancer misc Cancer stem cells misc Tumor-initiating cells misc Culturing conditions misc Surface markers misc Spheroid Culture Systems misc Metabolic identity misc Targeted therapy misc Inter- and intra-tumor heterogeneity Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
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topic_title	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies Colorectal cancer (dpeaa)DE-He213 Cancer stem cells (dpeaa)DE-He213 Tumor-initiating cells (dpeaa)DE-He213 Culturing conditions (dpeaa)DE-He213 Surface markers (dpeaa)DE-He213 Spheroid Culture Systems (dpeaa)DE-He213 Metabolic identity (dpeaa)DE-He213 Targeted therapy (dpeaa)DE-He213 Inter- and intra-tumor heterogeneity (dpeaa)DE-He213
topic	misc Colorectal cancer misc Cancer stem cells misc Tumor-initiating cells misc Culturing conditions misc Surface markers misc Spheroid Culture Systems misc Metabolic identity misc Targeted therapy misc Inter- and intra-tumor heterogeneity
topic_unstemmed	misc Colorectal cancer misc Cancer stem cells misc Tumor-initiating cells misc Culturing conditions misc Surface markers misc Spheroid Culture Systems misc Metabolic identity misc Targeted therapy misc Inter- and intra-tumor heterogeneity
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title	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
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title_full	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
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title_sort	tumor-initiating cells: a critical review of isolation approaches and new challenges in targeting strategies
title_auth	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
abstract	Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. © The Author(s). 2017
abstractGer	Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. © The Author(s). 2017
abstract_unstemmed	Abstract Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches. © The Author(s). 2017
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title_short	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
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up_date	2024-07-03T23:15:06.698Z
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