Arterial dissection in childhood Takayasu Arteritis: not as rare as thought

Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection i...
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Autor*in:	Aeschlimann, Florence A. [verfasserIn] Grosse-Wortmann, Lars Benseler, Susanne M. Laxer, Ronald M. Hebert, Diane Yeung, Rae S.M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Takayasu arteritis Vasculitis Children Imaging Arterial dissection

Anmerkung:	© The Author(s). 2016

Übergeordnetes Werk:	Enthalten in: Pediatric rheumatology - London : BioMed Central, 2003, 14(2016), 1 vom: 22. Sept.
Übergeordnetes Werk:	volume:14 ; year:2016 ; number:1 ; day:22 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12969-016-0115-3

Katalog-ID:	SPR029069351

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520			\|a Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA.
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allfields	10.1186/s12969-016-0115-3 doi (DE-627)SPR029069351 (SPR)s12969-016-0115-3-e DE-627 ger DE-627 rakwb eng Aeschlimann, Florence A. verfasserin aut Arterial dissection in childhood Takayasu Arteritis: not as rare as thought 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213 Grosse-Wortmann, Lars aut Benseler, Susanne M. aut Laxer, Ronald M. aut Hebert, Diane aut Yeung, Rae S.M. aut Enthalten in Pediatric rheumatology London : BioMed Central, 2003 14(2016), 1 vom: 22. Sept. (DE-627)527833746 (DE-600)2279468-2 1546-0096 nnns volume:14 year:2016 number:1 day:22 month:09 https://dx.doi.org/10.1186/s12969-016-0115-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 22 09
spelling	10.1186/s12969-016-0115-3 doi (DE-627)SPR029069351 (SPR)s12969-016-0115-3-e DE-627 ger DE-627 rakwb eng Aeschlimann, Florence A. verfasserin aut Arterial dissection in childhood Takayasu Arteritis: not as rare as thought 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213 Grosse-Wortmann, Lars aut Benseler, Susanne M. aut Laxer, Ronald M. aut Hebert, Diane aut Yeung, Rae S.M. aut Enthalten in Pediatric rheumatology London : BioMed Central, 2003 14(2016), 1 vom: 22. Sept. (DE-627)527833746 (DE-600)2279468-2 1546-0096 nnns volume:14 year:2016 number:1 day:22 month:09 https://dx.doi.org/10.1186/s12969-016-0115-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 22 09
allfields_unstemmed	10.1186/s12969-016-0115-3 doi (DE-627)SPR029069351 (SPR)s12969-016-0115-3-e DE-627 ger DE-627 rakwb eng Aeschlimann, Florence A. verfasserin aut Arterial dissection in childhood Takayasu Arteritis: not as rare as thought 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213 Grosse-Wortmann, Lars aut Benseler, Susanne M. aut Laxer, Ronald M. aut Hebert, Diane aut Yeung, Rae S.M. aut Enthalten in Pediatric rheumatology London : BioMed Central, 2003 14(2016), 1 vom: 22. Sept. (DE-627)527833746 (DE-600)2279468-2 1546-0096 nnns volume:14 year:2016 number:1 day:22 month:09 https://dx.doi.org/10.1186/s12969-016-0115-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 22 09
allfieldsGer	10.1186/s12969-016-0115-3 doi (DE-627)SPR029069351 (SPR)s12969-016-0115-3-e DE-627 ger DE-627 rakwb eng Aeschlimann, Florence A. verfasserin aut Arterial dissection in childhood Takayasu Arteritis: not as rare as thought 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213 Grosse-Wortmann, Lars aut Benseler, Susanne M. aut Laxer, Ronald M. aut Hebert, Diane aut Yeung, Rae S.M. aut Enthalten in Pediatric rheumatology London : BioMed Central, 2003 14(2016), 1 vom: 22. Sept. (DE-627)527833746 (DE-600)2279468-2 1546-0096 nnns volume:14 year:2016 number:1 day:22 month:09 https://dx.doi.org/10.1186/s12969-016-0115-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 22 09
allfieldsSound	10.1186/s12969-016-0115-3 doi (DE-627)SPR029069351 (SPR)s12969-016-0115-3-e DE-627 ger DE-627 rakwb eng Aeschlimann, Florence A. verfasserin aut Arterial dissection in childhood Takayasu Arteritis: not as rare as thought 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213 Grosse-Wortmann, Lars aut Benseler, Susanne M. aut Laxer, Ronald M. aut Hebert, Diane aut Yeung, Rae S.M. aut Enthalten in Pediatric rheumatology London : BioMed Central, 2003 14(2016), 1 vom: 22. Sept. (DE-627)527833746 (DE-600)2279468-2 1546-0096 nnns volume:14 year:2016 number:1 day:22 month:09 https://dx.doi.org/10.1186/s12969-016-0115-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2016 1 22 09
language	English
source	Enthalten in Pediatric rheumatology 14(2016), 1 vom: 22. Sept. volume:14 year:2016 number:1 day:22 month:09
sourceStr	Enthalten in Pediatric rheumatology 14(2016), 1 vom: 22. Sept. volume:14 year:2016 number:1 day:22 month:09
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topic_facet	Takayasu arteritis Vasculitis Children Imaging Arterial dissection
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author	Aeschlimann, Florence A.
spellingShingle	Aeschlimann, Florence A. misc Takayasu arteritis misc Vasculitis misc Children misc Imaging misc Arterial dissection Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
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topic_title	Arterial dissection in childhood Takayasu Arteritis: not as rare as thought Takayasu arteritis (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Children (dpeaa)DE-He213 Imaging (dpeaa)DE-He213 Arterial dissection (dpeaa)DE-He213
topic	misc Takayasu arteritis misc Vasculitis misc Children misc Imaging misc Arterial dissection
topic_unstemmed	misc Takayasu arteritis misc Vasculitis misc Children misc Imaging misc Arterial dissection
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title	Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
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title_full	Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
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author_browse	Aeschlimann, Florence A. Grosse-Wortmann, Lars Benseler, Susanne M. Laxer, Ronald M. Hebert, Diane Yeung, Rae S.M.
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title_sort	arterial dissection in childhood takayasu arteritis: not as rare as thought
title_auth	Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
abstract	Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. © The Author(s). 2016
abstractGer	Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. © The Author(s). 2016
abstract_unstemmed	Background Arterial vessel wall dissection is a rare, life-threatening and rarely described complication in childhood Takayasu Arteritis (cTA). Prevalence and risk factors for arterial dissection in cTA are unknown. We sought to study the prevalence and analyse risk factors for arterial dissection in cTA. Findings A single center retrospective review of all children with cTA was performed. Patients with arterial dissection at cTA diagnosis were reported in detail and compared to the remaining single center retrospective cohort of children without dissection. Disease activity was assessed by the Pediatric Vasculitis Disease Activity Score (PVAS). A total of 27 cTA patients (74 % girls) were included. Three children (11 %) presented with dissection at diagnosis of cTA. They had higher PVAS (median 21 versus 10, p = 0.26), increased neutrophils (p < 0.0001) and lower albumin levels (p = 0.05). Arterial hypertension was common in both groups: in 67 % of children with dissection and 54 % of those without. Conclusions Arterial dissection was more frequent in our cTA cohort than previously reported. Careful vascular imaging assessment is crucial to document this complication. High disease activity and markers of inflammation especially in combination with arterial hypertension, may be associated with the risk for vessel wall dissection in children with cTA. © The Author(s). 2016
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title_short	Arterial dissection in childhood Takayasu Arteritis: not as rare as thought
url	https://dx.doi.org/10.1186/s12969-016-0115-3
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author2	Grosse-Wortmann, Lars Benseler, Susanne M. Laxer, Ronald M. Hebert, Diane Yeung, Rae S.M.
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Arterial dissection in childhood Takayasu Arteritis: not as rare as thought

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