The emerging role of SPOP protein in tumorigenesis and cancer therapy

Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tum...
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Gespeichert in:

Autor*in:	Song, Yizuo [verfasserIn] Xu, Yichi Pan, Chunyu Yan, Linzhi Wang, Zhi-wei Zhu, Xueqiong

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	SPOP Oncoprotein Tumor suppressor Cancer Therapy

Anmerkung:	© The Author(s). 2020

Übergeordnetes Werk:	Enthalten in: Molecular cancer - London : Biomed Central, 2002, 19(2020), 1 vom: 04. Jan.
Übergeordnetes Werk:	volume:19 ; year:2020 ; number:1 ; day:04 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12943-019-1124-x

Katalog-ID:	SPR029115027

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matchkey_str	article:14764598:2020----::heegnrlosopoennuoieei
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allfields	10.1186/s12943-019-1124-x doi (DE-627)SPR029115027 (SPR)s12943-019-1124-x-e DE-627 ger DE-627 rakwb eng Song, Yizuo verfasserin aut The emerging role of SPOP protein in tumorigenesis and cancer therapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2020 Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Xu, Yichi aut Pan, Chunyu aut Yan, Linzhi aut Wang, Zhi-wei (orcid)0000-0002-6465-7779 aut Zhu, Xueqiong aut Enthalten in Molecular cancer London : Biomed Central, 2002 19(2020), 1 vom: 04. Jan. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:19 year:2020 number:1 day:04 month:01 https://dx.doi.org/10.1186/s12943-019-1124-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020 1 04 01
spelling	10.1186/s12943-019-1124-x doi (DE-627)SPR029115027 (SPR)s12943-019-1124-x-e DE-627 ger DE-627 rakwb eng Song, Yizuo verfasserin aut The emerging role of SPOP protein in tumorigenesis and cancer therapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2020 Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Xu, Yichi aut Pan, Chunyu aut Yan, Linzhi aut Wang, Zhi-wei (orcid)0000-0002-6465-7779 aut Zhu, Xueqiong aut Enthalten in Molecular cancer London : Biomed Central, 2002 19(2020), 1 vom: 04. Jan. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:19 year:2020 number:1 day:04 month:01 https://dx.doi.org/10.1186/s12943-019-1124-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020 1 04 01
allfields_unstemmed	10.1186/s12943-019-1124-x doi (DE-627)SPR029115027 (SPR)s12943-019-1124-x-e DE-627 ger DE-627 rakwb eng Song, Yizuo verfasserin aut The emerging role of SPOP protein in tumorigenesis and cancer therapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2020 Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Xu, Yichi aut Pan, Chunyu aut Yan, Linzhi aut Wang, Zhi-wei (orcid)0000-0002-6465-7779 aut Zhu, Xueqiong aut Enthalten in Molecular cancer London : Biomed Central, 2002 19(2020), 1 vom: 04. Jan. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:19 year:2020 number:1 day:04 month:01 https://dx.doi.org/10.1186/s12943-019-1124-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020 1 04 01
allfieldsGer	10.1186/s12943-019-1124-x doi (DE-627)SPR029115027 (SPR)s12943-019-1124-x-e DE-627 ger DE-627 rakwb eng Song, Yizuo verfasserin aut The emerging role of SPOP protein in tumorigenesis and cancer therapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2020 Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Xu, Yichi aut Pan, Chunyu aut Yan, Linzhi aut Wang, Zhi-wei (orcid)0000-0002-6465-7779 aut Zhu, Xueqiong aut Enthalten in Molecular cancer London : Biomed Central, 2002 19(2020), 1 vom: 04. Jan. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:19 year:2020 number:1 day:04 month:01 https://dx.doi.org/10.1186/s12943-019-1124-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020 1 04 01
allfieldsSound	10.1186/s12943-019-1124-x doi (DE-627)SPR029115027 (SPR)s12943-019-1124-x-e DE-627 ger DE-627 rakwb eng Song, Yizuo verfasserin aut The emerging role of SPOP protein in tumorigenesis and cancer therapy 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2020 Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213 Xu, Yichi aut Pan, Chunyu aut Yan, Linzhi aut Wang, Zhi-wei (orcid)0000-0002-6465-7779 aut Zhu, Xueqiong aut Enthalten in Molecular cancer London : Biomed Central, 2002 19(2020), 1 vom: 04. Jan. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:19 year:2020 number:1 day:04 month:01 https://dx.doi.org/10.1186/s12943-019-1124-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2020 1 04 01
language	English
source	Enthalten in Molecular cancer 19(2020), 1 vom: 04. Jan. volume:19 year:2020 number:1 day:04 month:01
sourceStr	Enthalten in Molecular cancer 19(2020), 1 vom: 04. Jan. volume:19 year:2020 number:1 day:04 month:01
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authorswithroles_txt_mv	Song, Yizuo @@aut@@ Xu, Yichi @@aut@@ Pan, Chunyu @@aut@@ Yan, Linzhi @@aut@@ Wang, Zhi-wei @@aut@@ Zhu, Xueqiong @@aut@@
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spellingShingle	Song, Yizuo misc SPOP misc Oncoprotein misc Tumor suppressor misc Cancer misc Therapy The emerging role of SPOP protein in tumorigenesis and cancer therapy
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topic_title	The emerging role of SPOP protein in tumorigenesis and cancer therapy SPOP (dpeaa)DE-He213 Oncoprotein (dpeaa)DE-He213 Tumor suppressor (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Therapy (dpeaa)DE-He213
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title	The emerging role of SPOP protein in tumorigenesis and cancer therapy
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title_full	The emerging role of SPOP protein in tumorigenesis and cancer therapy
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author_browse	Song, Yizuo Xu, Yichi Pan, Chunyu Yan, Linzhi Wang, Zhi-wei Zhu, Xueqiong
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title_sort	emerging role of spop protein in tumorigenesis and cancer therapy
title_auth	The emerging role of SPOP protein in tumorigenesis and cancer therapy
abstract	Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. © The Author(s). 2020
abstractGer	Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. © The Author(s). 2020
abstract_unstemmed	Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several studies revealed that SPOP exhibited oncogenic function in kidney cancer, suggesting that SPOP could exert its biological function in a cancer type-specific manner. The role of SPOP in thyroid, cervical, ovarian, bone and neurologic cancers has yet to be determined. In this review article, we describe the structure and regulation of SPOP in human cancer. Moreover, we highlight the critical role of SPOP in tumorigenesis based on three major categories: physiological evidence (animal models), pathological evidence (human cancer specimens) and biochemical evidence (downstream ubiquitin substrates). Furthermore, we note that SPOP could be a promising therapeutic target for cancer treatment. © The Author(s). 2020
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title_short	The emerging role of SPOP protein in tumorigenesis and cancer therapy
url	https://dx.doi.org/10.1186/s12943-019-1124-x
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author2	Xu, Yichi Pan, Chunyu Yan, Linzhi Wang, Zhi-wei Zhu, Xueqiong
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up_date	2024-07-03T23:33:06.376Z
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The emerging role of SPOP protein in tumorigenesis and cancer therapy

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