Biological effects of deuteronation: ATP synthase as an example

Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rath...
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Autor*in:	Olgun, Abdullah [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Electron Transport Chain Hepatitis Delta Virus Proton Couple Electron Transfer Versus Membrane Potential Heavy Water

Anmerkung:	© Olgun; licensee BioMed Central Ltd. 2007

Übergeordnetes Werk:	Enthalten in: Theoretical biology and medical modelling - London : BioMed Central, 2004, 4(2007), 1 vom: 22. Feb.
Übergeordnetes Werk:	volume:4 ; year:2007 ; number:1 ; day:22 ; month:02

Links:	Volltext

DOI / URN:	10.1186/1742-4682-4-9

Katalog-ID:	SPR029126088

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520			\|a Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging.
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allfields	10.1186/1742-4682-4-9 doi (DE-627)SPR029126088 (SPR)1742-4682-4-9-e DE-627 ger DE-627 rakwb eng Olgun, Abdullah verfasserin aut Biological effects of deuteronation: ATP synthase as an example 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Olgun; licensee BioMed Central Ltd. 2007 Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213 Enthalten in Theoretical biology and medical modelling London : BioMed Central, 2004 4(2007), 1 vom: 22. Feb. (DE-627)39178482X (DE-600)2156462-0 1742-4682 nnns volume:4 year:2007 number:1 day:22 month:02 https://dx.doi.org/10.1186/1742-4682-4-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 22 02
spelling	10.1186/1742-4682-4-9 doi (DE-627)SPR029126088 (SPR)1742-4682-4-9-e DE-627 ger DE-627 rakwb eng Olgun, Abdullah verfasserin aut Biological effects of deuteronation: ATP synthase as an example 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Olgun; licensee BioMed Central Ltd. 2007 Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213 Enthalten in Theoretical biology and medical modelling London : BioMed Central, 2004 4(2007), 1 vom: 22. Feb. (DE-627)39178482X (DE-600)2156462-0 1742-4682 nnns volume:4 year:2007 number:1 day:22 month:02 https://dx.doi.org/10.1186/1742-4682-4-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 22 02
allfields_unstemmed	10.1186/1742-4682-4-9 doi (DE-627)SPR029126088 (SPR)1742-4682-4-9-e DE-627 ger DE-627 rakwb eng Olgun, Abdullah verfasserin aut Biological effects of deuteronation: ATP synthase as an example 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Olgun; licensee BioMed Central Ltd. 2007 Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213 Enthalten in Theoretical biology and medical modelling London : BioMed Central, 2004 4(2007), 1 vom: 22. Feb. (DE-627)39178482X (DE-600)2156462-0 1742-4682 nnns volume:4 year:2007 number:1 day:22 month:02 https://dx.doi.org/10.1186/1742-4682-4-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 22 02
allfieldsGer	10.1186/1742-4682-4-9 doi (DE-627)SPR029126088 (SPR)1742-4682-4-9-e DE-627 ger DE-627 rakwb eng Olgun, Abdullah verfasserin aut Biological effects of deuteronation: ATP synthase as an example 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Olgun; licensee BioMed Central Ltd. 2007 Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213 Enthalten in Theoretical biology and medical modelling London : BioMed Central, 2004 4(2007), 1 vom: 22. Feb. (DE-627)39178482X (DE-600)2156462-0 1742-4682 nnns volume:4 year:2007 number:1 day:22 month:02 https://dx.doi.org/10.1186/1742-4682-4-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 22 02
allfieldsSound	10.1186/1742-4682-4-9 doi (DE-627)SPR029126088 (SPR)1742-4682-4-9-e DE-627 ger DE-627 rakwb eng Olgun, Abdullah verfasserin aut Biological effects of deuteronation: ATP synthase as an example 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Olgun; licensee BioMed Central Ltd. 2007 Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213 Enthalten in Theoretical biology and medical modelling London : BioMed Central, 2004 4(2007), 1 vom: 22. Feb. (DE-627)39178482X (DE-600)2156462-0 1742-4682 nnns volume:4 year:2007 number:1 day:22 month:02 https://dx.doi.org/10.1186/1742-4682-4-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 22 02
language	English
source	Enthalten in Theoretical biology and medical modelling 4(2007), 1 vom: 22. Feb. volume:4 year:2007 number:1 day:22 month:02
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topic_facet	Electron Transport Chain Hepatitis Delta Virus Proton Couple Electron Transfer Versus Membrane Potential Heavy Water
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author	Olgun, Abdullah
spellingShingle	Olgun, Abdullah misc Electron Transport Chain misc Hepatitis Delta Virus misc Proton Couple Electron Transfer misc Versus Membrane Potential misc Heavy Water Biological effects of deuteronation: ATP synthase as an example
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topic_title	Biological effects of deuteronation: ATP synthase as an example Electron Transport Chain (dpeaa)DE-He213 Hepatitis Delta Virus (dpeaa)DE-He213 Proton Couple Electron Transfer (dpeaa)DE-He213 Versus Membrane Potential (dpeaa)DE-He213 Heavy Water (dpeaa)DE-He213
topic	misc Electron Transport Chain misc Hepatitis Delta Virus misc Proton Couple Electron Transfer misc Versus Membrane Potential misc Heavy Water
topic_unstemmed	misc Electron Transport Chain misc Hepatitis Delta Virus misc Proton Couple Electron Transfer misc Versus Membrane Potential misc Heavy Water
topic_browse	misc Electron Transport Chain misc Hepatitis Delta Virus misc Proton Couple Electron Transfer misc Versus Membrane Potential misc Heavy Water
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Biological effects of deuteronation: ATP synthase as an example
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title_full	Biological effects of deuteronation: ATP synthase as an example
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title_sort	biological effects of deuteronation: atp synthase as an example
title_auth	Biological effects of deuteronation: ATP synthase as an example
abstract	Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. © Olgun; licensee BioMed Central Ltd. 2007
abstractGer	Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. © Olgun; licensee BioMed Central Ltd. 2007
abstract_unstemmed	Background In nature, deuterium/hydrogen ratio is ~1/6600, therefore one of ~3300 water ($ H_{2} $O) molecules is deuterated (HOD + $ D_{2} $O). In body fluids the ratio of deuterons to protons is ~1/15000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 61 on the subunit c of $ F_{0} $ part of ATP synthase is also ~1/15000. The contribution of deuteronation to the pKa of Asp 61 is 0.35. Theory and Discussion In mitochondria, the release of a deuteron into the matrix side half-channel of $ F_{0} $ is likely to be slower than that of a proton. As another example, deuteronation may slow down electron transfer in the electron transport chain (ETC) by interfering with proton coupled electron transport reactions (PCET), and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation, as exemplified by ATP synthase and the ETC, may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. © Olgun; licensee BioMed Central Ltd. 2007
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title_short	Biological effects of deuteronation: ATP synthase as an example
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Biological effects of deuteronation: ATP synthase as an example

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