A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands

Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility deli...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Garces, Ana [verfasserIn] McClure, Elizabeth M. Figueroa, Lester Pineda, Sayury Hambidge, K. Michael Krebs, Nancy F. Thorsten, Vanessa R. Wallace, Dennis D. Althabe, Fernando Goldenberg, Robert L.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Preterm Birth Neonatal Mortality Intervention Cluster Home Birth Antenatal Corticosteroid

Anmerkung:	© Garces et al. 2016

Übergeordnetes Werk:	Enthalten in: Reproductive health - London : BioMed Central, 2004, 13(2016), 1 vom: 24. Mai
Übergeordnetes Werk:	volume:13 ; year:2016 ; number:1 ; day:24 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12978-016-0178-0

Katalog-ID:	SPR029188148

Internformat


LEADER	01000caa a22002652 4500
001	SPR029188148
003	DE-627
005	20230519124120.0
007	cr uuu---uuuuu
008	201007s2016 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1186/s12978-016-0178-0 \|2 doi
035			\|a (DE-627)SPR029188148
035			\|a (SPR)s12978-016-0178-0-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Garces, Ana \|e verfasserin \|4 aut
245	1	2	\|a A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
264		1	\|c 2016
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © Garces et al. 2016
520			\|a Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096.
650		4	\|a Preterm Birth \|7 (dpeaa)DE-He213
650		4	\|a Neonatal Mortality \|7 (dpeaa)DE-He213
650		4	\|a Intervention Cluster \|7 (dpeaa)DE-He213
650		4	\|a Home Birth \|7 (dpeaa)DE-He213
650		4	\|a Antenatal Corticosteroid \|7 (dpeaa)DE-He213
700	1		\|a McClure, Elizabeth M. \|4 aut
700	1		\|a Figueroa, Lester \|4 aut
700	1		\|a Pineda, Sayury \|4 aut
700	1		\|a Hambidge, K. Michael \|4 aut
700	1		\|a Krebs, Nancy F. \|4 aut
700	1		\|a Thorsten, Vanessa R. \|4 aut
700	1		\|a Wallace, Dennis D. \|4 aut
700	1		\|a Althabe, Fernando \|4 aut
700	1		\|a Goldenberg, Robert L. \|4 aut
773	0	8	\|i Enthalten in \|t Reproductive health \|d London : BioMed Central, 2004 \|g 13(2016), 1 vom: 24. Mai \|w (DE-627)389462543 \|w (DE-600)2149029-6 \|x 1742-4755 \|7 nnns
773	1	8	\|g volume:13 \|g year:2016 \|g number:1 \|g day:24 \|g month:05
856	4	0	\|u https://dx.doi.org/10.1186/s12978-016-0178-0 \|z kostenfrei \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 13 \|j 2016 \|e 1 \|b 24 \|c 05

Indexfelder

author_variant	a g ag e m m em emm l f lf s p sp k m h km kmh n f k nf nfk v r t vr vrt d d w dd ddw f a fa r l g rl rlg
matchkey_str	article:17424755:2016----::mliaeeitretoicuigneaacriotrisoeueentlotltascaewtpeemitaae
hierarchy_sort_str	2016
publishDate	2016
allfields	10.1186/s12978-016-0178-0 doi (DE-627)SPR029188148 (SPR)s12978-016-0178-0-e DE-627 ger DE-627 rakwb eng Garces, Ana verfasserin aut A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Garces et al. 2016 Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213 McClure, Elizabeth M. aut Figueroa, Lester aut Pineda, Sayury aut Hambidge, K. Michael aut Krebs, Nancy F. aut Thorsten, Vanessa R. aut Wallace, Dennis D. aut Althabe, Fernando aut Goldenberg, Robert L. aut Enthalten in Reproductive health London : BioMed Central, 2004 13(2016), 1 vom: 24. Mai (DE-627)389462543 (DE-600)2149029-6 1742-4755 nnns volume:13 year:2016 number:1 day:24 month:05 https://dx.doi.org/10.1186/s12978-016-0178-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 1 24 05
spelling	10.1186/s12978-016-0178-0 doi (DE-627)SPR029188148 (SPR)s12978-016-0178-0-e DE-627 ger DE-627 rakwb eng Garces, Ana verfasserin aut A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Garces et al. 2016 Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213 McClure, Elizabeth M. aut Figueroa, Lester aut Pineda, Sayury aut Hambidge, K. Michael aut Krebs, Nancy F. aut Thorsten, Vanessa R. aut Wallace, Dennis D. aut Althabe, Fernando aut Goldenberg, Robert L. aut Enthalten in Reproductive health London : BioMed Central, 2004 13(2016), 1 vom: 24. Mai (DE-627)389462543 (DE-600)2149029-6 1742-4755 nnns volume:13 year:2016 number:1 day:24 month:05 https://dx.doi.org/10.1186/s12978-016-0178-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 1 24 05
allfields_unstemmed	10.1186/s12978-016-0178-0 doi (DE-627)SPR029188148 (SPR)s12978-016-0178-0-e DE-627 ger DE-627 rakwb eng Garces, Ana verfasserin aut A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Garces et al. 2016 Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213 McClure, Elizabeth M. aut Figueroa, Lester aut Pineda, Sayury aut Hambidge, K. Michael aut Krebs, Nancy F. aut Thorsten, Vanessa R. aut Wallace, Dennis D. aut Althabe, Fernando aut Goldenberg, Robert L. aut Enthalten in Reproductive health London : BioMed Central, 2004 13(2016), 1 vom: 24. Mai (DE-627)389462543 (DE-600)2149029-6 1742-4755 nnns volume:13 year:2016 number:1 day:24 month:05 https://dx.doi.org/10.1186/s12978-016-0178-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 1 24 05
allfieldsGer	10.1186/s12978-016-0178-0 doi (DE-627)SPR029188148 (SPR)s12978-016-0178-0-e DE-627 ger DE-627 rakwb eng Garces, Ana verfasserin aut A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Garces et al. 2016 Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213 McClure, Elizabeth M. aut Figueroa, Lester aut Pineda, Sayury aut Hambidge, K. Michael aut Krebs, Nancy F. aut Thorsten, Vanessa R. aut Wallace, Dennis D. aut Althabe, Fernando aut Goldenberg, Robert L. aut Enthalten in Reproductive health London : BioMed Central, 2004 13(2016), 1 vom: 24. Mai (DE-627)389462543 (DE-600)2149029-6 1742-4755 nnns volume:13 year:2016 number:1 day:24 month:05 https://dx.doi.org/10.1186/s12978-016-0178-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 1 24 05
allfieldsSound	10.1186/s12978-016-0178-0 doi (DE-627)SPR029188148 (SPR)s12978-016-0178-0-e DE-627 ger DE-627 rakwb eng Garces, Ana verfasserin aut A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Garces et al. 2016 Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213 McClure, Elizabeth M. aut Figueroa, Lester aut Pineda, Sayury aut Hambidge, K. Michael aut Krebs, Nancy F. aut Thorsten, Vanessa R. aut Wallace, Dennis D. aut Althabe, Fernando aut Goldenberg, Robert L. aut Enthalten in Reproductive health London : BioMed Central, 2004 13(2016), 1 vom: 24. Mai (DE-627)389462543 (DE-600)2149029-6 1742-4755 nnns volume:13 year:2016 number:1 day:24 month:05 https://dx.doi.org/10.1186/s12978-016-0178-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2016 1 24 05
language	English
source	Enthalten in Reproductive health 13(2016), 1 vom: 24. Mai volume:13 year:2016 number:1 day:24 month:05
sourceStr	Enthalten in Reproductive health 13(2016), 1 vom: 24. Mai volume:13 year:2016 number:1 day:24 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Preterm Birth Neonatal Mortality Intervention Cluster Home Birth Antenatal Corticosteroid
isfreeaccess_bool	true
container_title	Reproductive health
authorswithroles_txt_mv	Garces, Ana @@aut@@ McClure, Elizabeth M. @@aut@@ Figueroa, Lester @@aut@@ Pineda, Sayury @@aut@@ Hambidge, K. Michael @@aut@@ Krebs, Nancy F. @@aut@@ Thorsten, Vanessa R. @@aut@@ Wallace, Dennis D. @@aut@@ Althabe, Fernando @@aut@@ Goldenberg, Robert L. @@aut@@
publishDateDaySort_date	2016-05-24T00:00:00Z
hierarchy_top_id	389462543
id	SPR029188148
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR029188148</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519124120.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2016 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12978-016-0178-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR029188148</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12978-016-0178-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Garces, Ana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Garces et al. 2016</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Preterm Birth</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neonatal Mortality</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intervention Cluster</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Home Birth</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antenatal Corticosteroid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McClure, Elizabeth M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Figueroa, Lester</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pineda, Sayury</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hambidge, K. Michael</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krebs, Nancy F.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thorsten, Vanessa R.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wallace, Dennis D.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Althabe, Fernando</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goldenberg, Robert L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reproductive health</subfield><subfield code="d">London : BioMed Central, 2004</subfield><subfield code="g">13(2016), 1 vom: 24. Mai</subfield><subfield code="w">(DE-627)389462543</subfield><subfield code="w">(DE-600)2149029-6</subfield><subfield code="x">1742-4755</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:1</subfield><subfield code="g">day:24</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s12978-016-0178-0</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">2016</subfield><subfield code="e">1</subfield><subfield code="b">24</subfield><subfield code="c">05</subfield></datafield></record></collection>
author	Garces, Ana
spellingShingle	Garces, Ana misc Preterm Birth misc Neonatal Mortality misc Intervention Cluster misc Home Birth misc Antenatal Corticosteroid A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
authorStr	Garces, Ana
ppnlink_with_tag_str_mv	@@773@@(DE-627)389462543
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut
collection	springer
remote_str	true
illustrated	Not Illustrated
issn	1742-4755
topic_title	A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands Preterm Birth (dpeaa)DE-He213 Neonatal Mortality (dpeaa)DE-He213 Intervention Cluster (dpeaa)DE-He213 Home Birth (dpeaa)DE-He213 Antenatal Corticosteroid (dpeaa)DE-He213
topic	misc Preterm Birth misc Neonatal Mortality misc Intervention Cluster misc Home Birth misc Antenatal Corticosteroid
topic_unstemmed	misc Preterm Birth misc Neonatal Mortality misc Intervention Cluster misc Home Birth misc Antenatal Corticosteroid
topic_browse	misc Preterm Birth misc Neonatal Mortality misc Intervention Cluster misc Home Birth misc Antenatal Corticosteroid
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Reproductive health
hierarchy_parent_id	389462543
hierarchy_top_title	Reproductive health
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)389462543 (DE-600)2149029-6
title	A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
ctrlnum	(DE-627)SPR029188148 (SPR)s12978-016-0178-0-e
title_full	A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
author_sort	Garces, Ana
journal	Reproductive health
journalStr	Reproductive health
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2016
contenttype_str_mv	txt
author_browse	Garces, Ana McClure, Elizabeth M. Figueroa, Lester Pineda, Sayury Hambidge, K. Michael Krebs, Nancy F. Thorsten, Vanessa R. Wallace, Dennis D. Althabe, Fernando Goldenberg, Robert L.
container_volume	13
format_se	Elektronische Aufsätze
author-letter	Garces, Ana
doi_str_mv	10.1186/s12978-016-0178-0
title_sort	multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the guatemalan western highlands
title_auth	A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
abstract	Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. © Garces et al. 2016
abstractGer	Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. © Garces et al. 2016
abstract_unstemmed	Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096. © Garces et al. 2016
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	1
title_short	A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands
url	https://dx.doi.org/10.1186/s12978-016-0178-0
remote_bool	true
author2	McClure, Elizabeth M. Figueroa, Lester Pineda, Sayury Hambidge, K. Michael Krebs, Nancy F. Thorsten, Vanessa R. Wallace, Dennis D. Althabe, Fernando Goldenberg, Robert L.
author2Str	McClure, Elizabeth M. Figueroa, Lester Pineda, Sayury Hambidge, K. Michael Krebs, Nancy F. Thorsten, Vanessa R. Wallace, Dennis D. Althabe, Fernando Goldenberg, Robert L.
ppnlink	389462543
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1186/s12978-016-0178-0
up_date	2024-07-03T23:52:36.709Z
_version_	1803603942267944960
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR029188148</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519124120.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2016 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12978-016-0178-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR029188148</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12978-016-0178-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Garces, Ana</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Garces et al. 2016</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The Global Network for Women’s and Children’s Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala’s improvement in neonatal mortality was by far the largest. Methods We used data available from the ACT trial as well as pretrial data in an attempt to understand why neonatal mortality may have decreased in the intervention clusters in <$ 5^{th} $ percentile infants in Chimaltenango, Guatemala. The intervention and control clusters were compared in regards to ACS use, the various types of medical care, outcomes in facility and community births and among births in various birth weight categories. Results Neonatal mortality decreased to a greater extent in the intervention compared to the control clusters in the <$ 5^{th} $ percentile infants in Guatemala during the ACT Trial. ACS use for the <$ 5^{th} $ percentile infants in the intervention clusters was 49.1 % compared to 13.8 % in the control clusters. Many measures of the quality of obstetric and neonatal care improved to a greater extent in the intervention compared to the control clusters during the trial. Births in facilities and births weighing 1500 to 2500 g had the greatest reduction in neonatal mortality. Conclusions The combination of improved care and greater ACS use may potentially account for the observed difference in neonatal mortality between the intervention and control clusters. Trial registration Clinicaltrials.gov: NCT01084096.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Preterm Birth</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neonatal Mortality</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intervention Cluster</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Home Birth</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antenatal Corticosteroid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">McClure, Elizabeth M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Figueroa, Lester</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pineda, Sayury</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hambidge, K. Michael</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Krebs, Nancy F.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Thorsten, Vanessa R.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wallace, Dennis D.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Althabe, Fernando</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goldenberg, Robert L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Reproductive health</subfield><subfield code="d">London : BioMed Central, 2004</subfield><subfield code="g">13(2016), 1 vom: 24. Mai</subfield><subfield code="w">(DE-627)389462543</subfield><subfield code="w">(DE-600)2149029-6</subfield><subfield code="x">1742-4755</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:2016</subfield><subfield code="g">number:1</subfield><subfield code="g">day:24</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s12978-016-0178-0</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">2016</subfield><subfield code="e">1</subfield><subfield code="b">24</subfield><subfield code="c">05</subfield></datafield></record></collection>
score	7.4005127

Nicht das Richtige dabei?

Schreiben Sie uns!

A multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth: a case study from the Guatemalan Western Highlands

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?