Immunosenescence and gender: a study in healthy Cubans
Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of ind...
Ausführliche Beschreibung
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| Autor*in: |
García Verdecia, Beatriz [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© García Verdecia et al.; licensee BioMed Central Ltd. 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Immunity & ageing - London : BioMed Central, 2004, 10(2013), 1 vom: 30. Apr. |
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| Übergeordnetes Werk: |
volume:10 ; year:2013 ; number:1 ; day:30 ; month:04 |
| Links: |
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| DOI / URN: |
10.1186/1742-4933-10-16 |
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| Katalog-ID: |
SPR029197694 |
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| 520 | |a Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. | ||
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| 700 | 1 | |a Saavedra Hernández, Danay |4 aut | |
| 700 | 1 | |a Lorenzo-Luaces, Patricia |4 aut | |
| 700 | 1 | |a de Jesús Badía Alvarez, Teresita |4 aut | |
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| 700 | 1 | |a Lage Dávila, Agustín |4 aut | |
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10.1186/1742-4933-10-16 doi (DE-627)SPR029197694 (SPR)1742-4933-10-16-e DE-627 ger DE-627 rakwb eng García Verdecia, Beatriz verfasserin aut Immunosenescence and gender: a study in healthy Cubans 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © García Verdecia et al.; licensee BioMed Central Ltd. 2013 Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. Epstein Barr Virus (dpeaa)DE-He213 Total Lymphocyte Count (dpeaa)DE-He213 Thymus Involution (dpeaa)DE-He213 Seropositive Individual (dpeaa)DE-He213 Antigenic Load (dpeaa)DE-He213 Saavedra Hernández, Danay aut Lorenzo-Luaces, Patricia aut de Jesús Badía Alvarez, Teresita aut Leonard Rupalé, Idrissa aut Mazorra Herrera, Zaima aut Crombet Ramos, Tania aut Lage Dávila, Agustín aut Enthalten in Immunity & ageing London : BioMed Central, 2004 10(2013), 1 vom: 30. Apr. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:10 year:2013 number:1 day:30 month:04 https://dx.doi.org/10.1186/1742-4933-10-16 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2013 1 30 04 |
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10.1186/1742-4933-10-16 doi (DE-627)SPR029197694 (SPR)1742-4933-10-16-e DE-627 ger DE-627 rakwb eng García Verdecia, Beatriz verfasserin aut Immunosenescence and gender: a study in healthy Cubans 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © García Verdecia et al.; licensee BioMed Central Ltd. 2013 Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. Epstein Barr Virus (dpeaa)DE-He213 Total Lymphocyte Count (dpeaa)DE-He213 Thymus Involution (dpeaa)DE-He213 Seropositive Individual (dpeaa)DE-He213 Antigenic Load (dpeaa)DE-He213 Saavedra Hernández, Danay aut Lorenzo-Luaces, Patricia aut de Jesús Badía Alvarez, Teresita aut Leonard Rupalé, Idrissa aut Mazorra Herrera, Zaima aut Crombet Ramos, Tania aut Lage Dávila, Agustín aut Enthalten in Immunity & ageing London : BioMed Central, 2004 10(2013), 1 vom: 30. Apr. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:10 year:2013 number:1 day:30 month:04 https://dx.doi.org/10.1186/1742-4933-10-16 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2013 1 30 04 |
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10.1186/1742-4933-10-16 doi (DE-627)SPR029197694 (SPR)1742-4933-10-16-e DE-627 ger DE-627 rakwb eng García Verdecia, Beatriz verfasserin aut Immunosenescence and gender: a study in healthy Cubans 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © García Verdecia et al.; licensee BioMed Central Ltd. 2013 Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. Epstein Barr Virus (dpeaa)DE-He213 Total Lymphocyte Count (dpeaa)DE-He213 Thymus Involution (dpeaa)DE-He213 Seropositive Individual (dpeaa)DE-He213 Antigenic Load (dpeaa)DE-He213 Saavedra Hernández, Danay aut Lorenzo-Luaces, Patricia aut de Jesús Badía Alvarez, Teresita aut Leonard Rupalé, Idrissa aut Mazorra Herrera, Zaima aut Crombet Ramos, Tania aut Lage Dávila, Agustín aut Enthalten in Immunity & ageing London : BioMed Central, 2004 10(2013), 1 vom: 30. Apr. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:10 year:2013 number:1 day:30 month:04 https://dx.doi.org/10.1186/1742-4933-10-16 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2013 1 30 04 |
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10.1186/1742-4933-10-16 doi (DE-627)SPR029197694 (SPR)1742-4933-10-16-e DE-627 ger DE-627 rakwb eng García Verdecia, Beatriz verfasserin aut Immunosenescence and gender: a study in healthy Cubans 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © García Verdecia et al.; licensee BioMed Central Ltd. 2013 Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. Epstein Barr Virus (dpeaa)DE-He213 Total Lymphocyte Count (dpeaa)DE-He213 Thymus Involution (dpeaa)DE-He213 Seropositive Individual (dpeaa)DE-He213 Antigenic Load (dpeaa)DE-He213 Saavedra Hernández, Danay aut Lorenzo-Luaces, Patricia aut de Jesús Badía Alvarez, Teresita aut Leonard Rupalé, Idrissa aut Mazorra Herrera, Zaima aut Crombet Ramos, Tania aut Lage Dávila, Agustín aut Enthalten in Immunity & ageing London : BioMed Central, 2004 10(2013), 1 vom: 30. Apr. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:10 year:2013 number:1 day:30 month:04 https://dx.doi.org/10.1186/1742-4933-10-16 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2013 1 30 04 |
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10.1186/1742-4933-10-16 doi (DE-627)SPR029197694 (SPR)1742-4933-10-16-e DE-627 ger DE-627 rakwb eng García Verdecia, Beatriz verfasserin aut Immunosenescence and gender: a study in healthy Cubans 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © García Verdecia et al.; licensee BioMed Central Ltd. 2013 Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. Epstein Barr Virus (dpeaa)DE-He213 Total Lymphocyte Count (dpeaa)DE-He213 Thymus Involution (dpeaa)DE-He213 Seropositive Individual (dpeaa)DE-He213 Antigenic Load (dpeaa)DE-He213 Saavedra Hernández, Danay aut Lorenzo-Luaces, Patricia aut de Jesús Badía Alvarez, Teresita aut Leonard Rupalé, Idrissa aut Mazorra Herrera, Zaima aut Crombet Ramos, Tania aut Lage Dávila, Agustín aut Enthalten in Immunity & ageing London : BioMed Central, 2004 10(2013), 1 vom: 30. Apr. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:10 year:2013 number:1 day:30 month:04 https://dx.doi.org/10.1186/1742-4933-10-16 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2013 1 30 04 |
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García Verdecia, Beatriz @@aut@@ Saavedra Hernández, Danay @@aut@@ Lorenzo-Luaces, Patricia @@aut@@ de Jesús Badía Alvarez, Teresita @@aut@@ Leonard Rupalé, Idrissa @@aut@@ Mazorra Herrera, Zaima @@aut@@ Crombet Ramos, Tania @@aut@@ Lage Dávila, Agustín @@aut@@ |
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García Verdecia, Beatriz Saavedra Hernández, Danay Lorenzo-Luaces, Patricia de Jesús Badía Alvarez, Teresita Leonard Rupalé, Idrissa Mazorra Herrera, Zaima Crombet Ramos, Tania Lage Dávila, Agustín |
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immunosenescence and gender: a study in healthy cubans |
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Immunosenescence and gender: a study in healthy Cubans |
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Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. © García Verdecia et al.; licensee BioMed Central Ltd. 2013 |
| abstractGer |
Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. © García Verdecia et al.; licensee BioMed Central Ltd. 2013 |
| abstract_unstemmed |
Background The progressive decline in the immune function during ageing is termed immunosenescence. Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. These patterns could have implications in the design of immunotherapy in the elderly. © García Verdecia et al.; licensee BioMed Central Ltd. 2013 |
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Saavedra Hernández, Danay Lorenzo-Luaces, Patricia de Jesús Badía Alvarez, Teresita Leonard Rupalé, Idrissa Mazorra Herrera, Zaima Crombet Ramos, Tania Lage Dávila, Agustín |
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Saavedra Hernández, Danay Lorenzo-Luaces, Patricia de Jesús Badía Alvarez, Teresita Leonard Rupalé, Idrissa Mazorra Herrera, Zaima Crombet Ramos, Tania Lage Dávila, Agustín |
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Previous studies have reported differences between males and females in the distribution and cell responses of lymphocyte subsets. Most studies of immunosenescence have been done in populations of industrialized countries living in a rather cold environment, and facing lower antigenic challenges such as Cytomegalovirus (CMV). The aim of this study was to determine the effect of ageing on lymphocytes in a population with a high prevalence of CMV infection in all ages, and to compare gender differences related to the immunosenescence markers. Results Different populations of peripheral blood leukocytes from healthy young and old IgG-CMV seropositive individuals were examined using flow cytometry. With age, the number and frequency of B cells and T cells significantly decreased, while highly differentiated T cells increased. Such changes were different in males and females. The age-associated decline of less differentiated lymphocyte subsets (CD19, CD4 and CD8 cells) and the increase of highly differentiated T cells were more prominent in females. In males, there were no significant changes in CD19, CD4 and CD8 subsets but there was a significant increase in the proportion of highly differentiated T cells. Conclusion Shifts in lymphocyte subsets distribution were influenced by age and gender in an IgG-CMV seropositive population. These results suggest different patterns of immunosenescence in respect to gender differences. 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