CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing

Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes i...
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Autor*in:	Tserel, Liina [verfasserIn] Limbach, Maia Saare, Mario Kisand, Kai Metspalu, Andres Milani, Lili Peterson, Pärt

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Monocytes DNA methylation Ageing

Anmerkung:	© Tserel et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: Immunity & ageing - London : BioMed Central, 2004, 11(2014), 1 vom: 09. Jan.
Übergeordnetes Werk:	volume:11 ; year:2014 ; number:1 ; day:09 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1742-4933-11-1

Katalog-ID:	SPR029197996

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520			\|a Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes.
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allfields	10.1186/1742-4933-11-1 doi (DE-627)SPR029197996 (SPR)1742-4933-11-1-e DE-627 ger DE-627 rakwb eng Tserel, Liina verfasserin aut CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tserel et al.; licensee BioMed Central Ltd. 2014 Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Limbach, Maia aut Saare, Mario aut Kisand, Kai aut Metspalu, Andres aut Milani, Lili aut Peterson, Pärt aut Enthalten in Immunity & ageing London : BioMed Central, 2004 11(2014), 1 vom: 09. Jan. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:11 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1742-4933-11-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2014 1 09 01
spelling	10.1186/1742-4933-11-1 doi (DE-627)SPR029197996 (SPR)1742-4933-11-1-e DE-627 ger DE-627 rakwb eng Tserel, Liina verfasserin aut CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tserel et al.; licensee BioMed Central Ltd. 2014 Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Limbach, Maia aut Saare, Mario aut Kisand, Kai aut Metspalu, Andres aut Milani, Lili aut Peterson, Pärt aut Enthalten in Immunity & ageing London : BioMed Central, 2004 11(2014), 1 vom: 09. Jan. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:11 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1742-4933-11-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2014 1 09 01
allfields_unstemmed	10.1186/1742-4933-11-1 doi (DE-627)SPR029197996 (SPR)1742-4933-11-1-e DE-627 ger DE-627 rakwb eng Tserel, Liina verfasserin aut CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tserel et al.; licensee BioMed Central Ltd. 2014 Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Limbach, Maia aut Saare, Mario aut Kisand, Kai aut Metspalu, Andres aut Milani, Lili aut Peterson, Pärt aut Enthalten in Immunity & ageing London : BioMed Central, 2004 11(2014), 1 vom: 09. Jan. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:11 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1742-4933-11-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2014 1 09 01
allfieldsGer	10.1186/1742-4933-11-1 doi (DE-627)SPR029197996 (SPR)1742-4933-11-1-e DE-627 ger DE-627 rakwb eng Tserel, Liina verfasserin aut CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tserel et al.; licensee BioMed Central Ltd. 2014 Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Limbach, Maia aut Saare, Mario aut Kisand, Kai aut Metspalu, Andres aut Milani, Lili aut Peterson, Pärt aut Enthalten in Immunity & ageing London : BioMed Central, 2004 11(2014), 1 vom: 09. Jan. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:11 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1742-4933-11-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2014 1 09 01
allfieldsSound	10.1186/1742-4933-11-1 doi (DE-627)SPR029197996 (SPR)1742-4933-11-1-e DE-627 ger DE-627 rakwb eng Tserel, Liina verfasserin aut CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tserel et al.; licensee BioMed Central Ltd. 2014 Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213 Limbach, Maia aut Saare, Mario aut Kisand, Kai aut Metspalu, Andres aut Milani, Lili aut Peterson, Pärt aut Enthalten in Immunity & ageing London : BioMed Central, 2004 11(2014), 1 vom: 09. Jan. (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:11 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1742-4933-11-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2014 1 09 01
language	English
source	Enthalten in Immunity & ageing 11(2014), 1 vom: 09. Jan. volume:11 year:2014 number:1 day:09 month:01
sourceStr	Enthalten in Immunity & ageing 11(2014), 1 vom: 09. Jan. volume:11 year:2014 number:1 day:09 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Monocytes DNA methylation Ageing
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container_title	Immunity & ageing
authorswithroles_txt_mv	Tserel, Liina @@aut@@ Limbach, Maia @@aut@@ Saare, Mario @@aut@@ Kisand, Kai @@aut@@ Metspalu, Andres @@aut@@ Milani, Lili @@aut@@ Peterson, Pärt @@aut@@
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They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). 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author	Tserel, Liina
spellingShingle	Tserel, Liina misc Monocytes misc DNA methylation misc Ageing CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
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topic_title	CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing Monocytes (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Ageing (dpeaa)DE-He213
topic	misc Monocytes misc DNA methylation misc Ageing
topic_unstemmed	misc Monocytes misc DNA methylation misc Ageing
topic_browse	misc Monocytes misc DNA methylation misc Ageing
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title	CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
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title_full	CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
author_sort	Tserel, Liina
journal	Immunity & ageing
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author_browse	Tserel, Liina Limbach, Maia Saare, Mario Kisand, Kai Metspalu, Andres Milani, Lili Peterson, Pärt
container_volume	11
format_se	Elektronische Aufsätze
author-letter	Tserel, Liina
doi_str_mv	10.1186/1742-4933-11-1
title_sort	cpg sites associated with nrp1, nrxn2 and mir-29b-2 are hypomethylated in monocytes during ageing
title_auth	CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
abstract	Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. © Tserel et al.; licensee BioMed Central Ltd. 2014
abstractGer	Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. © Tserel et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Background Ageing affects many components of the immune system, including innate immune cells like monocytes. They are important in the early response to pathogens and for their role to differentiate into macrophages and dendritic cells. Recent studies have revealed significant age-related changes in genomic DNA methylation in peripheral blood mononuclear cells, however information on epigenetic changes in specific leukocyte subsets is still lacking. Here, we aimed to analyse DNA methylation in purified monocyte populations from young and elderly individuals. Findings We analysed the methylation changes in monocytes purified from young and elderly individuals using the HumanMethylation450 BeadChip array. Interestingly, we found that among 26 differentially methylated CpG sites, the majority of sites were hypomethylated in elderly individuals. The most hypomethylated CpG sites were located in neuropilin 1 (NRP1; cg24892069) and neurexin 2 (NRXN2; cg27209729) genes, and upstream of miR-29b-2 gene (cg10501210). The age-related hypomethylation of these three sites was confirmed in a separate group of young and elderly individuals. Conclusions We identified significant age-related hypomethylation in human purified monocytes at CpG sites within the regions of NRP1, NRXN2 and miR-29b-2 genes. © Tserel et al.; licensee BioMed Central Ltd. 2014
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title_short	CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing
url	https://dx.doi.org/10.1186/1742-4933-11-1
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author2	Limbach, Maia Saare, Mario Kisand, Kai Metspalu, Andres Milani, Lili Peterson, Pärt
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up_date	2024-07-03T23:55:31.629Z
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CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing

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