The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study

Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recru...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bottomley, Christian [verfasserIn] Bojang, Abdoulie Smith, Peter G Darboe, Ousainou Antonio, Martin Foster-Nyarko, Ebenezer Kampmann, Beate Greenwood, Brian D’Alessandro, Umberto Roca, Anna

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Non-specific vaccine effects Measles DTP Nasopharyngeal bacterial carriage

Anmerkung:	© Bottomley et al.; licensee BioMed Central. 2015

Übergeordnetes Werk:	Enthalten in: Emerging Themes in Epidemiology - London : BioMed Central, 2004, 12(2015), 1 vom: 16. Jan.
Übergeordnetes Werk:	volume:12 ; year:2015 ; number:1 ; day:16 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12982-014-0022-3

Katalog-ID:	SPR029207649

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245	1	4	\|a The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
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520			\|a Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination.
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allfields	10.1186/s12982-014-0022-3 doi (DE-627)SPR029207649 (SPR)s12982-014-0022-3-e DE-627 ger DE-627 rakwb eng Bottomley, Christian verfasserin aut The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bottomley et al.; licensee BioMed Central. 2015 Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213 Bojang, Abdoulie aut Smith, Peter G aut Darboe, Ousainou aut Antonio, Martin aut Foster-Nyarko, Ebenezer aut Kampmann, Beate aut Greenwood, Brian aut D’Alessandro, Umberto aut Roca, Anna aut Enthalten in Emerging Themes in Epidemiology London : BioMed Central, 2004 12(2015), 1 vom: 16. Jan. (DE-627)461908042 (DE-600)2164388-X 1742-7622 nnns volume:12 year:2015 number:1 day:16 month:01 https://dx.doi.org/10.1186/s12982-014-0022-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 16 01
spelling	10.1186/s12982-014-0022-3 doi (DE-627)SPR029207649 (SPR)s12982-014-0022-3-e DE-627 ger DE-627 rakwb eng Bottomley, Christian verfasserin aut The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bottomley et al.; licensee BioMed Central. 2015 Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213 Bojang, Abdoulie aut Smith, Peter G aut Darboe, Ousainou aut Antonio, Martin aut Foster-Nyarko, Ebenezer aut Kampmann, Beate aut Greenwood, Brian aut D’Alessandro, Umberto aut Roca, Anna aut Enthalten in Emerging Themes in Epidemiology London : BioMed Central, 2004 12(2015), 1 vom: 16. Jan. (DE-627)461908042 (DE-600)2164388-X 1742-7622 nnns volume:12 year:2015 number:1 day:16 month:01 https://dx.doi.org/10.1186/s12982-014-0022-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 16 01
allfields_unstemmed	10.1186/s12982-014-0022-3 doi (DE-627)SPR029207649 (SPR)s12982-014-0022-3-e DE-627 ger DE-627 rakwb eng Bottomley, Christian verfasserin aut The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bottomley et al.; licensee BioMed Central. 2015 Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213 Bojang, Abdoulie aut Smith, Peter G aut Darboe, Ousainou aut Antonio, Martin aut Foster-Nyarko, Ebenezer aut Kampmann, Beate aut Greenwood, Brian aut D’Alessandro, Umberto aut Roca, Anna aut Enthalten in Emerging Themes in Epidemiology London : BioMed Central, 2004 12(2015), 1 vom: 16. Jan. (DE-627)461908042 (DE-600)2164388-X 1742-7622 nnns volume:12 year:2015 number:1 day:16 month:01 https://dx.doi.org/10.1186/s12982-014-0022-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 16 01
allfieldsGer	10.1186/s12982-014-0022-3 doi (DE-627)SPR029207649 (SPR)s12982-014-0022-3-e DE-627 ger DE-627 rakwb eng Bottomley, Christian verfasserin aut The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bottomley et al.; licensee BioMed Central. 2015 Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213 Bojang, Abdoulie aut Smith, Peter G aut Darboe, Ousainou aut Antonio, Martin aut Foster-Nyarko, Ebenezer aut Kampmann, Beate aut Greenwood, Brian aut D’Alessandro, Umberto aut Roca, Anna aut Enthalten in Emerging Themes in Epidemiology London : BioMed Central, 2004 12(2015), 1 vom: 16. Jan. (DE-627)461908042 (DE-600)2164388-X 1742-7622 nnns volume:12 year:2015 number:1 day:16 month:01 https://dx.doi.org/10.1186/s12982-014-0022-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 16 01
allfieldsSound	10.1186/s12982-014-0022-3 doi (DE-627)SPR029207649 (SPR)s12982-014-0022-3-e DE-627 ger DE-627 rakwb eng Bottomley, Christian verfasserin aut The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bottomley et al.; licensee BioMed Central. 2015 Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213 Bojang, Abdoulie aut Smith, Peter G aut Darboe, Ousainou aut Antonio, Martin aut Foster-Nyarko, Ebenezer aut Kampmann, Beate aut Greenwood, Brian aut D’Alessandro, Umberto aut Roca, Anna aut Enthalten in Emerging Themes in Epidemiology London : BioMed Central, 2004 12(2015), 1 vom: 16. Jan. (DE-627)461908042 (DE-600)2164388-X 1742-7622 nnns volume:12 year:2015 number:1 day:16 month:01 https://dx.doi.org/10.1186/s12982-014-0022-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 16 01
language	English
source	Enthalten in Emerging Themes in Epidemiology 12(2015), 1 vom: 16. Jan. volume:12 year:2015 number:1 day:16 month:01
sourceStr	Enthalten in Emerging Themes in Epidemiology 12(2015), 1 vom: 16. Jan. volume:12 year:2015 number:1 day:16 month:01
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The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. 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author	Bottomley, Christian
spellingShingle	Bottomley, Christian misc Non-specific vaccine effects misc Measles misc DTP misc Nasopharyngeal bacterial carriage The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
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topic_title	The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study Non-specific vaccine effects (dpeaa)DE-He213 Measles (dpeaa)DE-He213 DTP (dpeaa)DE-He213 Nasopharyngeal bacterial carriage (dpeaa)DE-He213
topic	misc Non-specific vaccine effects misc Measles misc DTP misc Nasopharyngeal bacterial carriage
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title	The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
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title_full	The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
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author_browse	Bottomley, Christian Bojang, Abdoulie Smith, Peter G Darboe, Ousainou Antonio, Martin Foster-Nyarko, Ebenezer Kampmann, Beate Greenwood, Brian D’Alessandro, Umberto Roca, Anna
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title_sort	impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
title_auth	The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
abstract	Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. © Bottomley et al.; licensee BioMed Central. 2015
abstractGer	Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. © Bottomley et al.; licensee BioMed Central. 2015
abstract_unstemmed	Background There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. Conclusions Nasopharyngeal bacterial carriage is unaffected by DTP-Hib-HepB vaccination and reduced after measles-yellow fever vaccination. © Bottomley et al.; licensee BioMed Central. 2015
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title_short	The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study
url	https://dx.doi.org/10.1186/s12982-014-0022-3
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author2	Bojang, Abdoulie Smith, Peter G Darboe, Ousainou Antonio, Martin Foster-Nyarko, Ebenezer Kampmann, Beate Greenwood, Brian D’Alessandro, Umberto Roca, Anna
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up_date	2024-07-03T23:58:10.286Z
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The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx. Methods A cohort of children from rural Gambia was recruited at birth and followed up for one year. Nasopharyngeal swabs were taken immediately after birth, every two weeks for the first six months and then every other month. The presence of bacteria in the nasopharynx (Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus) was compared before and after the administration of DTP-Hib-HepB and measles-yellow fever vaccines. Results A total of 1,779 nasopharyngeal swabs were collected from 136 children for whom vaccination data were available. The prevalence of bacterial carriage was high: 82.2% S. pneumoniae, 30.6%, S.aureus, 27.8% H. influenzae. Carriage of H. influenzae (OR = 0.36; 95% CI: 0.13, 0.99) and S. pneumoniae (OR = 0.25; 95% CI: 0.07, 0.90) were significantly reduced after measles-yellow fever vaccination; while DTP-Hib-HepB had no effect on bacterial carriage. 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The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study

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