Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection
Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interferenc...
Ausführliche Beschreibung
Autor*in: |
Raaben, Matthijs [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2007 |
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Schlagwörter: |
Human Immunodeficiency Virus Type |
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Anmerkung: |
© Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Übergeordnetes Werk: |
Enthalten in: Virology journal - London : BioMed Central, 2004, 4(2007), 1 vom: 07. Juni |
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Übergeordnetes Werk: |
volume:4 ; year:2007 ; number:1 ; day:07 ; month:06 |
Links: |
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DOI / URN: |
10.1186/1743-422X-4-55 |
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Katalog-ID: |
SPR029233984 |
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520 | |a Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. | ||
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10.1186/1743-422X-4-55 doi (DE-627)SPR029233984 (SPR)1743-422X-4-55-e DE-627 ger DE-627 rakwb eng Raaben, Matthijs verfasserin aut Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. Indomethacin (dpeaa)DE-He213 Human Immunodeficiency Virus Type (dpeaa)DE-He213 Severe Acute Respiratory Syndrome (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Bovine Leukemia Virus (dpeaa)DE-He213 Einerhand, Alexandra WC aut Taminiau, Lucas JA aut van Houdt, Michel aut Bouma, Janneke aut Raatgeep, Rolien H aut Büller, Hans A aut de Haan, Cornelis AM aut Rossen, John WA aut Enthalten in Virology journal London : BioMed Central, 2004 4(2007), 1 vom: 07. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:4 year:2007 number:1 day:07 month:06 https://dx.doi.org/10.1186/1743-422X-4-55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 07 06 |
spelling |
10.1186/1743-422X-4-55 doi (DE-627)SPR029233984 (SPR)1743-422X-4-55-e DE-627 ger DE-627 rakwb eng Raaben, Matthijs verfasserin aut Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. Indomethacin (dpeaa)DE-He213 Human Immunodeficiency Virus Type (dpeaa)DE-He213 Severe Acute Respiratory Syndrome (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Bovine Leukemia Virus (dpeaa)DE-He213 Einerhand, Alexandra WC aut Taminiau, Lucas JA aut van Houdt, Michel aut Bouma, Janneke aut Raatgeep, Rolien H aut Büller, Hans A aut de Haan, Cornelis AM aut Rossen, John WA aut Enthalten in Virology journal London : BioMed Central, 2004 4(2007), 1 vom: 07. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:4 year:2007 number:1 day:07 month:06 https://dx.doi.org/10.1186/1743-422X-4-55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 07 06 |
allfields_unstemmed |
10.1186/1743-422X-4-55 doi (DE-627)SPR029233984 (SPR)1743-422X-4-55-e DE-627 ger DE-627 rakwb eng Raaben, Matthijs verfasserin aut Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. Indomethacin (dpeaa)DE-He213 Human Immunodeficiency Virus Type (dpeaa)DE-He213 Severe Acute Respiratory Syndrome (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Bovine Leukemia Virus (dpeaa)DE-He213 Einerhand, Alexandra WC aut Taminiau, Lucas JA aut van Houdt, Michel aut Bouma, Janneke aut Raatgeep, Rolien H aut Büller, Hans A aut de Haan, Cornelis AM aut Rossen, John WA aut Enthalten in Virology journal London : BioMed Central, 2004 4(2007), 1 vom: 07. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:4 year:2007 number:1 day:07 month:06 https://dx.doi.org/10.1186/1743-422X-4-55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 07 06 |
allfieldsGer |
10.1186/1743-422X-4-55 doi (DE-627)SPR029233984 (SPR)1743-422X-4-55-e DE-627 ger DE-627 rakwb eng Raaben, Matthijs verfasserin aut Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. Indomethacin (dpeaa)DE-He213 Human Immunodeficiency Virus Type (dpeaa)DE-He213 Severe Acute Respiratory Syndrome (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Bovine Leukemia Virus (dpeaa)DE-He213 Einerhand, Alexandra WC aut Taminiau, Lucas JA aut van Houdt, Michel aut Bouma, Janneke aut Raatgeep, Rolien H aut Büller, Hans A aut de Haan, Cornelis AM aut Rossen, John WA aut Enthalten in Virology journal London : BioMed Central, 2004 4(2007), 1 vom: 07. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:4 year:2007 number:1 day:07 month:06 https://dx.doi.org/10.1186/1743-422X-4-55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 07 06 |
allfieldsSound |
10.1186/1743-422X-4-55 doi (DE-627)SPR029233984 (SPR)1743-422X-4-55-e DE-627 ger DE-627 rakwb eng Raaben, Matthijs verfasserin aut Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. Indomethacin (dpeaa)DE-He213 Human Immunodeficiency Virus Type (dpeaa)DE-He213 Severe Acute Respiratory Syndrome (dpeaa)DE-He213 Firefly Luciferase (dpeaa)DE-He213 Bovine Leukemia Virus (dpeaa)DE-He213 Einerhand, Alexandra WC aut Taminiau, Lucas JA aut van Houdt, Michel aut Bouma, Janneke aut Raatgeep, Rolien H aut Büller, Hans A aut de Haan, Cornelis AM aut Rossen, John WA aut Enthalten in Virology journal London : BioMed Central, 2004 4(2007), 1 vom: 07. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:4 year:2007 number:1 day:07 month:06 https://dx.doi.org/10.1186/1743-422X-4-55 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2007 1 07 06 |
language |
English |
source |
Enthalten in Virology journal 4(2007), 1 vom: 07. Juni volume:4 year:2007 number:1 day:07 month:06 |
sourceStr |
Enthalten in Virology journal 4(2007), 1 vom: 07. Juni volume:4 year:2007 number:1 day:07 month:06 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
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Indomethacin Human Immunodeficiency Virus Type Severe Acute Respiratory Syndrome Firefly Luciferase Bovine Leukemia Virus |
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Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy. © Raaben et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. 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