Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway

Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza vi...
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Autor*in:	Terrier, Olivier [verfasserIn] Josset, Laurence Textoris, Julien Marcel, Virginie Cartet, Gaëlle Ferraris, Olivier N'Guyen, Catherine Lina, Bruno Diaz, Jean-Jacques Bourdon, Jean-Christophe Rosa-Calatrava, Manuel

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Influenza A549 Cell Influenza Virus H7N1 Virus Avian Influenza Virus

Anmerkung:	© Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Virology journal - London : BioMed Central, 2004, 8(2011), 1 vom: 08. Juni
Übergeordnetes Werk:	volume:8 ; year:2011 ; number:1 ; day:08 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1743-422X-8-285

Katalog-ID:	SPR029246601

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245	1	0	\|a Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
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520			\|a Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation.
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700	1		\|a Josset, Laurence \|4 aut
700	1		\|a Textoris, Julien \|4 aut
700	1		\|a Marcel, Virginie \|4 aut
700	1		\|a Cartet, Gaëlle \|4 aut
700	1		\|a Ferraris, Olivier \|4 aut
700	1		\|a N'Guyen, Catherine \|4 aut
700	1		\|a Lina, Bruno \|4 aut
700	1		\|a Diaz, Jean-Jacques \|4 aut
700	1		\|a Bourdon, Jean-Christophe \|4 aut
700	1		\|a Rosa-Calatrava, Manuel \|4 aut
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Indexfelder

author_variant	o t ot l j lj j t jt v m vm g c gc o f of c n cn b l bl j j d jjd j c b jcb m r c mrc
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allfields	10.1186/1743-422X-8-285 doi (DE-627)SPR029246601 (SPR)1743-422X-8-285-e DE-627 ger DE-627 rakwb eng Terrier, Olivier verfasserin aut Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213 Josset, Laurence aut Textoris, Julien aut Marcel, Virginie aut Cartet, Gaëlle aut Ferraris, Olivier aut N'Guyen, Catherine aut Lina, Bruno aut Diaz, Jean-Jacques aut Bourdon, Jean-Christophe aut Rosa-Calatrava, Manuel aut Enthalten in Virology journal London : BioMed Central, 2004 8(2011), 1 vom: 08. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:8 year:2011 number:1 day:08 month:06 https://dx.doi.org/10.1186/1743-422X-8-285 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1 08 06
spelling	10.1186/1743-422X-8-285 doi (DE-627)SPR029246601 (SPR)1743-422X-8-285-e DE-627 ger DE-627 rakwb eng Terrier, Olivier verfasserin aut Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213 Josset, Laurence aut Textoris, Julien aut Marcel, Virginie aut Cartet, Gaëlle aut Ferraris, Olivier aut N'Guyen, Catherine aut Lina, Bruno aut Diaz, Jean-Jacques aut Bourdon, Jean-Christophe aut Rosa-Calatrava, Manuel aut Enthalten in Virology journal London : BioMed Central, 2004 8(2011), 1 vom: 08. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:8 year:2011 number:1 day:08 month:06 https://dx.doi.org/10.1186/1743-422X-8-285 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1 08 06
allfields_unstemmed	10.1186/1743-422X-8-285 doi (DE-627)SPR029246601 (SPR)1743-422X-8-285-e DE-627 ger DE-627 rakwb eng Terrier, Olivier verfasserin aut Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213 Josset, Laurence aut Textoris, Julien aut Marcel, Virginie aut Cartet, Gaëlle aut Ferraris, Olivier aut N'Guyen, Catherine aut Lina, Bruno aut Diaz, Jean-Jacques aut Bourdon, Jean-Christophe aut Rosa-Calatrava, Manuel aut Enthalten in Virology journal London : BioMed Central, 2004 8(2011), 1 vom: 08. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:8 year:2011 number:1 day:08 month:06 https://dx.doi.org/10.1186/1743-422X-8-285 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1 08 06
allfieldsGer	10.1186/1743-422X-8-285 doi (DE-627)SPR029246601 (SPR)1743-422X-8-285-e DE-627 ger DE-627 rakwb eng Terrier, Olivier verfasserin aut Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213 Josset, Laurence aut Textoris, Julien aut Marcel, Virginie aut Cartet, Gaëlle aut Ferraris, Olivier aut N'Guyen, Catherine aut Lina, Bruno aut Diaz, Jean-Jacques aut Bourdon, Jean-Christophe aut Rosa-Calatrava, Manuel aut Enthalten in Virology journal London : BioMed Central, 2004 8(2011), 1 vom: 08. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:8 year:2011 number:1 day:08 month:06 https://dx.doi.org/10.1186/1743-422X-8-285 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1 08 06
allfieldsSound	10.1186/1743-422X-8-285 doi (DE-627)SPR029246601 (SPR)1743-422X-8-285-e DE-627 ger DE-627 rakwb eng Terrier, Olivier verfasserin aut Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213 Josset, Laurence aut Textoris, Julien aut Marcel, Virginie aut Cartet, Gaëlle aut Ferraris, Olivier aut N'Guyen, Catherine aut Lina, Bruno aut Diaz, Jean-Jacques aut Bourdon, Jean-Christophe aut Rosa-Calatrava, Manuel aut Enthalten in Virology journal London : BioMed Central, 2004 8(2011), 1 vom: 08. Juni (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:8 year:2011 number:1 day:08 month:06 https://dx.doi.org/10.1186/1743-422X-8-285 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1 08 06
language	English
source	Enthalten in Virology journal 8(2011), 1 vom: 08. Juni volume:8 year:2011 number:1 day:08 month:06
sourceStr	Enthalten in Virology journal 8(2011), 1 vom: 08. Juni volume:8 year:2011 number:1 day:08 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Influenza A549 Cell Influenza Virus H7N1 Virus Avian Influenza Virus
isfreeaccess_bool	true
container_title	Virology journal
authorswithroles_txt_mv	Terrier, Olivier @@aut@@ Josset, Laurence @@aut@@ Textoris, Julien @@aut@@ Marcel, Virginie @@aut@@ Cartet, Gaëlle @@aut@@ Ferraris, Olivier @@aut@@ N'Guyen, Catherine @@aut@@ Lina, Bruno @@aut@@ Diaz, Jean-Jacques @@aut@@ Bourdon, Jean-Christophe @@aut@@ Rosa-Calatrava, Manuel @@aut@@
publishDateDaySort_date	2011-06-08T00:00:00Z
hierarchy_top_id	394165004
id	SPR029246601
language_de	englisch
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author	Terrier, Olivier
spellingShingle	Terrier, Olivier misc Influenza misc A549 Cell misc Influenza Virus misc H7N1 Virus misc Avian Influenza Virus Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
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topic_title	Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway Influenza (dpeaa)DE-He213 A549 Cell (dpeaa)DE-He213 Influenza Virus (dpeaa)DE-He213 H7N1 Virus (dpeaa)DE-He213 Avian Influenza Virus (dpeaa)DE-He213
topic	misc Influenza misc A549 Cell misc Influenza Virus misc H7N1 Virus misc Avian Influenza Virus
topic_unstemmed	misc Influenza misc A549 Cell misc Influenza Virus misc H7N1 Virus misc Avian Influenza Virus
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title	Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
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title_full	Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
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author_browse	Terrier, Olivier Josset, Laurence Textoris, Julien Marcel, Virginie Cartet, Gaëlle Ferraris, Olivier N'Guyen, Catherine Lina, Bruno Diaz, Jean-Jacques Bourdon, Jean-Christophe Rosa-Calatrava, Manuel
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title_sort	cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza a viruses reveals an overall down-regulation of the host p53 pathway
title_auth	Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
abstract	Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Influenza viruses can modulate and hijack several cellular signalling pathways to efficiently support their replication. We recently investigated and compared the cellular gene expression profiles of human lung A549 cells infected by five different subtypes of human and avian influenza viruses (Josset et al. Plos One 2010). Using these transcriptomic data, we have focused our analysis on the modulation of the p53 pathway in response to influenza infection. Results Our results were supported by both RT-qPCR and western blot analyses and reveal multiple alterations of the p53 pathway during infection. A down-regulation of mRNA expression was observed for the main regulators of p53 protein stability during infection by the complete set of viruses tested, and a significant decrease in p53 mRNA expression was also observed in H5N1 infected cells. In addition, several p53 target genes were also down-regulated by these influenza viruses and the expression of their product reduced. Conclusions Our data reveal that influenza viruses cause an overall down-regulation of the host p53 pathway and highlight this pathway and p53 protein itself as important viral targets in the altering of apoptotic processes and in cell-cycle regulation. © Terrier et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway
url	https://dx.doi.org/10.1186/1743-422X-8-285
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author2	Josset, Laurence Textoris, Julien Marcel, Virginie Cartet, Gaëlle Ferraris, Olivier N'Guyen, Catherine Lina, Bruno Diaz, Jean-Jacques Bourdon, Jean-Christophe Rosa-Calatrava, Manuel
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Cellular transcriptional profiling in human lung epithelial cells infected by different subtypes of influenza A viruses reveals an overall down-regulation of the host p53 pathway

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