Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects
Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained durin...
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| Autor*in: |
Okon, Monica D. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
Idiopathic intracranial hypertension Cerebrospinal fluid pressure waveform |
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| Anmerkung: |
© The Author(s) 2018 |
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| Übergeordnetes Werk: |
Enthalten in: Cerebrospinal fluid research - London : BioMed Central, 2004, 15(2018), 1 vom: 01. Aug. |
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| Übergeordnetes Werk: |
volume:15 ; year:2018 ; number:1 ; day:01 ; month:08 |
| Links: |
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| DOI / URN: |
10.1186/s12987-018-0106-5 |
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| Katalog-ID: |
SPR029292859 |
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| 100 | 1 | |a Okon, Monica D. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects |
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| 520 | |a Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. | ||
| 650 | 4 | |a Idiopathic intracranial hypertension |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cerebrospinal fluid pressure waveform |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cerebrospinal fluid pressure pulse amplitude |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Craniospinal compliance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pressure–volume curves |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Compliance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cerebrospinal fluid pressure |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Roberts, Cynthia J. |4 aut | |
| 700 | 1 | |a Mahmoud, Ashraf M. |4 aut | |
| 700 | 1 | |a Springer, Andrew N. |4 aut | |
| 700 | 1 | |a Small, Robert H. |4 aut | |
| 700 | 1 | |a McGregor, John M. |4 aut | |
| 700 | 1 | |a Katz, Steven E. |4 aut | |
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10.1186/s12987-018-0106-5 doi (DE-627)SPR029292859 (SPR)s12987-018-0106-5-e DE-627 ger DE-627 rakwb eng Okon, Monica D. verfasserin aut Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 Roberts, Cynthia J. aut Mahmoud, Ashraf M. aut Springer, Andrew N. aut Small, Robert H. aut McGregor, John M. aut Katz, Steven E. aut Enthalten in Cerebrospinal fluid research London : BioMed Central, 2004 15(2018), 1 vom: 01. Aug. (DE-627)476171717 (DE-600)2171132-X 1743-8454 nnns volume:15 year:2018 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12987-018-0106-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_2003 AR 15 2018 1 01 08 |
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10.1186/s12987-018-0106-5 doi (DE-627)SPR029292859 (SPR)s12987-018-0106-5-e DE-627 ger DE-627 rakwb eng Okon, Monica D. verfasserin aut Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 Roberts, Cynthia J. aut Mahmoud, Ashraf M. aut Springer, Andrew N. aut Small, Robert H. aut McGregor, John M. aut Katz, Steven E. aut Enthalten in Cerebrospinal fluid research London : BioMed Central, 2004 15(2018), 1 vom: 01. Aug. (DE-627)476171717 (DE-600)2171132-X 1743-8454 nnns volume:15 year:2018 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12987-018-0106-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_2003 AR 15 2018 1 01 08 |
| allfields_unstemmed |
10.1186/s12987-018-0106-5 doi (DE-627)SPR029292859 (SPR)s12987-018-0106-5-e DE-627 ger DE-627 rakwb eng Okon, Monica D. verfasserin aut Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 Roberts, Cynthia J. aut Mahmoud, Ashraf M. aut Springer, Andrew N. aut Small, Robert H. aut McGregor, John M. aut Katz, Steven E. aut Enthalten in Cerebrospinal fluid research London : BioMed Central, 2004 15(2018), 1 vom: 01. Aug. (DE-627)476171717 (DE-600)2171132-X 1743-8454 nnns volume:15 year:2018 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12987-018-0106-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_2003 AR 15 2018 1 01 08 |
| allfieldsGer |
10.1186/s12987-018-0106-5 doi (DE-627)SPR029292859 (SPR)s12987-018-0106-5-e DE-627 ger DE-627 rakwb eng Okon, Monica D. verfasserin aut Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 Roberts, Cynthia J. aut Mahmoud, Ashraf M. aut Springer, Andrew N. aut Small, Robert H. aut McGregor, John M. aut Katz, Steven E. aut Enthalten in Cerebrospinal fluid research London : BioMed Central, 2004 15(2018), 1 vom: 01. Aug. (DE-627)476171717 (DE-600)2171132-X 1743-8454 nnns volume:15 year:2018 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12987-018-0106-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_2003 AR 15 2018 1 01 08 |
| allfieldsSound |
10.1186/s12987-018-0106-5 doi (DE-627)SPR029292859 (SPR)s12987-018-0106-5-e DE-627 ger DE-627 rakwb eng Okon, Monica D. verfasserin aut Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 Roberts, Cynthia J. aut Mahmoud, Ashraf M. aut Springer, Andrew N. aut Small, Robert H. aut McGregor, John M. aut Katz, Steven E. aut Enthalten in Cerebrospinal fluid research London : BioMed Central, 2004 15(2018), 1 vom: 01. Aug. (DE-627)476171717 (DE-600)2171132-X 1743-8454 nnns volume:15 year:2018 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12987-018-0106-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_2003 AR 15 2018 1 01 08 |
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Okon, Monica D. @@aut@@ Roberts, Cynthia J. @@aut@@ Mahmoud, Ashraf M. @@aut@@ Springer, Andrew N. @@aut@@ Small, Robert H. @@aut@@ McGregor, John M. @@aut@@ Katz, Steven E. @@aut@@ |
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The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. 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Okon, Monica D. misc Idiopathic intracranial hypertension misc Cerebrospinal fluid pressure waveform misc Cerebrospinal fluid pressure pulse amplitude misc Craniospinal compliance misc Pressure–volume curves misc Compliance misc Cerebrospinal fluid pressure Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects |
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Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects Idiopathic intracranial hypertension (dpeaa)DE-He213 Cerebrospinal fluid pressure waveform (dpeaa)DE-He213 Cerebrospinal fluid pressure pulse amplitude (dpeaa)DE-He213 Craniospinal compliance (dpeaa)DE-He213 Pressure–volume curves (dpeaa)DE-He213 Compliance (dpeaa)DE-He213 Cerebrospinal fluid pressure (dpeaa)DE-He213 |
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characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects |
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Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects |
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Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. © The Author(s) 2018 |
| abstractGer |
Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. © The Author(s) 2018 |
| abstract_unstemmed |
Background Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH. Methods Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal. Joinpoint regression models were used to calculate compliance from CSF pressure and the corresponding volume removed at each increment for each subject. Twelve subjects had their CSFP waveform recorded with an electronic transducer. Body mass index, mean CSFP, and cerebral perfusion pressure (CPP) were also calculated. T-tests were used to compare measurements, and correlations were performed between parameters. Results Cerebrospinal fluid pressure, CSFP pulse amplitude (CPA), and CPP were found to be significantly different (p < 0.05) before and after the LP. CSFP and CPA decreased after the LP, while CPP increased. The craniospinal compliance significantly increased (p < 0.05) post-LP. CPA and CSFP were significantly positively correlated. Conclusions Both low craniospinal compliance (at high CSFP) and high craniospinal compliance (at low CSFP) regions were determined. The CSFP waveform morphology in IIH was characterized and CPA was found to be positively correlated to the magnitude of CSFP. Future studies will investigate how craniospinal compliance may correlate to symptoms and/or response to therapy in IIH subjects. © The Author(s) 2018 |
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