The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice

Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generate...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Cox, Peter J [verfasserIn] Pitcher, Tom Trim, Steven A Bell, Christine H Qin, Wenning Kinloch, Ross A

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Dorsal Root Ganglion Sciatic Nerve Chronic Constriction Injury Nocifensive Behaviour Hotplate Test

Anmerkung:	© Cox et al; licensee BioMed Central Ltd. 2008

Übergeordnetes Werk:	Enthalten in: Molecular pain - London : Sage, 2005, 4(2008), 1 vom: 15. Jan.
Übergeordnetes Werk:	volume:4 ; year:2008 ; number:1 ; day:15 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1744-8069-4-2

Katalog-ID:	SPR029303656

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245	1	4	\|a The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
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520			\|a Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice.
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700	1		\|a Kinloch, Ross A \|4 aut
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author_variant	p j c pj pjc t p tp s a t sa sat c h b ch chb w q wq r a k ra rak
matchkey_str	article:17448069:2008----::hefcodltooterhnpoenopercpogcgnmgo
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publishDate	2008
allfields	10.1186/1744-8069-4-2 doi (DE-627)SPR029303656 (SPR)1744-8069-4-2-e DE-627 ger DE-627 rakwb eng Cox, Peter J verfasserin aut The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cox et al; licensee BioMed Central Ltd. 2008 Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213 Pitcher, Tom aut Trim, Steven A aut Bell, Christine H aut Qin, Wenning aut Kinloch, Ross A aut Enthalten in Molecular pain London : Sage, 2005 4(2008), 1 vom: 15. Jan. (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:4 year:2008 number:1 day:15 month:01 https://dx.doi.org/10.1186/1744-8069-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2008 1 15 01
spelling	10.1186/1744-8069-4-2 doi (DE-627)SPR029303656 (SPR)1744-8069-4-2-e DE-627 ger DE-627 rakwb eng Cox, Peter J verfasserin aut The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cox et al; licensee BioMed Central Ltd. 2008 Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213 Pitcher, Tom aut Trim, Steven A aut Bell, Christine H aut Qin, Wenning aut Kinloch, Ross A aut Enthalten in Molecular pain London : Sage, 2005 4(2008), 1 vom: 15. Jan. (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:4 year:2008 number:1 day:15 month:01 https://dx.doi.org/10.1186/1744-8069-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2008 1 15 01
allfields_unstemmed	10.1186/1744-8069-4-2 doi (DE-627)SPR029303656 (SPR)1744-8069-4-2-e DE-627 ger DE-627 rakwb eng Cox, Peter J verfasserin aut The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cox et al; licensee BioMed Central Ltd. 2008 Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213 Pitcher, Tom aut Trim, Steven A aut Bell, Christine H aut Qin, Wenning aut Kinloch, Ross A aut Enthalten in Molecular pain London : Sage, 2005 4(2008), 1 vom: 15. Jan. (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:4 year:2008 number:1 day:15 month:01 https://dx.doi.org/10.1186/1744-8069-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2008 1 15 01
allfieldsGer	10.1186/1744-8069-4-2 doi (DE-627)SPR029303656 (SPR)1744-8069-4-2-e DE-627 ger DE-627 rakwb eng Cox, Peter J verfasserin aut The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cox et al; licensee BioMed Central Ltd. 2008 Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213 Pitcher, Tom aut Trim, Steven A aut Bell, Christine H aut Qin, Wenning aut Kinloch, Ross A aut Enthalten in Molecular pain London : Sage, 2005 4(2008), 1 vom: 15. Jan. (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:4 year:2008 number:1 day:15 month:01 https://dx.doi.org/10.1186/1744-8069-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2008 1 15 01
allfieldsSound	10.1186/1744-8069-4-2 doi (DE-627)SPR029303656 (SPR)1744-8069-4-2-e DE-627 ger DE-627 rakwb eng Cox, Peter J verfasserin aut The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cox et al; licensee BioMed Central Ltd. 2008 Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213 Pitcher, Tom aut Trim, Steven A aut Bell, Christine H aut Qin, Wenning aut Kinloch, Ross A aut Enthalten in Molecular pain London : Sage, 2005 4(2008), 1 vom: 15. Jan. (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:4 year:2008 number:1 day:15 month:01 https://dx.doi.org/10.1186/1744-8069-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2008 1 15 01
language	English
source	Enthalten in Molecular pain 4(2008), 1 vom: 15. Jan. volume:4 year:2008 number:1 day:15 month:01
sourceStr	Enthalten in Molecular pain 4(2008), 1 vom: 15. Jan. volume:4 year:2008 number:1 day:15 month:01
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institution	findex.gbv.de
topic_facet	Dorsal Root Ganglion Sciatic Nerve Chronic Constriction Injury Nocifensive Behaviour Hotplate Test
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container_title	Molecular pain
authorswithroles_txt_mv	Cox, Peter J @@aut@@ Pitcher, Tom @@aut@@ Trim, Steven A @@aut@@ Bell, Christine H @@aut@@ Qin, Wenning @@aut@@ Kinloch, Ross A @@aut@@
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author	Cox, Peter J
spellingShingle	Cox, Peter J misc Dorsal Root Ganglion misc Sciatic Nerve misc Chronic Constriction Injury misc Nocifensive Behaviour misc Hotplate Test The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
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topic_title	The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice Dorsal Root Ganglion (dpeaa)DE-He213 Sciatic Nerve (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Nocifensive Behaviour (dpeaa)DE-He213 Hotplate Test (dpeaa)DE-He213
topic	misc Dorsal Root Ganglion misc Sciatic Nerve misc Chronic Constriction Injury misc Nocifensive Behaviour misc Hotplate Test
topic_unstemmed	misc Dorsal Root Ganglion misc Sciatic Nerve misc Chronic Constriction Injury misc Nocifensive Behaviour misc Hotplate Test
topic_browse	misc Dorsal Root Ganglion misc Sciatic Nerve misc Chronic Constriction Injury misc Nocifensive Behaviour misc Hotplate Test
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title	The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
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title_full	The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
author_sort	Cox, Peter J
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author_browse	Cox, Peter J Pitcher, Tom Trim, Steven A Bell, Christine H Qin, Wenning Kinloch, Ross A
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title_sort	effect of deletion of the orphan g – protein coupled receptor (gpcr) gene mrge on pain-like behaviours in mice
title_auth	The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
abstract	Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. © Cox et al; licensee BioMed Central Ltd. 2008
abstractGer	Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. © Cox et al; licensee BioMed Central Ltd. 2008
abstract_unstemmed	Background The orphan GPCR MrgE is one of an extended family of GPCRs that are expressed in dorsal root ganglia (DRG). Based on these expression patterns it has been suggested that GPCRs like MrgE may play a role in nociception however, to date, no direct supporting evidence has emerged. We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models. The effect of MrgE gene deletion on expression of Mrgs and genes involved in sensory neurone function was also investigated. Results The absence of MrgE had no effect on the development of pain responses to a noxious chemical stimulus or an acute thermal stimulus. However, in contrast, the development but not the maintenance of neuropathic pain was affected by deletion of MrgE. The expression of Mrg genes was not significantly affected in the MrgE knockout (KO) mice with the sole exception of MrgF. In addition, the expression of 77 of 84 genes involved in sensory neuron development and function was also unaffected by deletion of MrgE. Of the 7 genes affected by MrgE deletion, 4 have previously been implicated in nociception. Conclusion The data suggests that MrgE may play a role in selective pain behavioural responses in mice. © Cox et al; licensee BioMed Central Ltd. 2008
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title_short	The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice
url	https://dx.doi.org/10.1186/1744-8069-4-2
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author2	Pitcher, Tom Trim, Steven A Bell, Christine H Qin, Wenning Kinloch, Ross A
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up_date	2024-07-04T00:24:45.418Z
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The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice

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