The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation
Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clin...
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| Autor*in: |
Mobascher, Arian [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Anmerkung: |
© Mobascher et al; licensee BioMed Central Ltd. 2010 |
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| Übergeordnetes Werk: |
Enthalten in: Molecular pain - London : Sage, 2005, 6(2010), 1 vom: 31. Mai |
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| Übergeordnetes Werk: |
volume:6 ; year:2010 ; number:1 ; day:31 ; month:05 |
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| DOI / URN: |
10.1186/1744-8069-6-32 |
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| Katalog-ID: |
SPR029305578 |
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| 520 | |a Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. | ||
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10.1186/1744-8069-6-32 doi (DE-627)SPR029305578 (SPR)1744-8069-6-32-e DE-627 ger DE-627 rakwb eng Mobascher, Arian verfasserin aut The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mobascher et al; licensee BioMed Central Ltd. 2010 Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 Brinkmeyer, Juergen aut Thiele, Holger aut Toliat, Mohammad R aut Steffens, Michael aut Warbrick, Tracy aut Musso, Francesco aut Wittsack, Hans-Joerg aut Saleh, Andreas aut Schnitzler, Alfons aut Winterer, Georg aut Enthalten in Molecular pain London : Sage, 2005 6(2010), 1 vom: 31. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:6 year:2010 number:1 day:31 month:05 https://dx.doi.org/10.1186/1744-8069-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1 31 05 |
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10.1186/1744-8069-6-32 doi (DE-627)SPR029305578 (SPR)1744-8069-6-32-e DE-627 ger DE-627 rakwb eng Mobascher, Arian verfasserin aut The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mobascher et al; licensee BioMed Central Ltd. 2010 Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 Brinkmeyer, Juergen aut Thiele, Holger aut Toliat, Mohammad R aut Steffens, Michael aut Warbrick, Tracy aut Musso, Francesco aut Wittsack, Hans-Joerg aut Saleh, Andreas aut Schnitzler, Alfons aut Winterer, Georg aut Enthalten in Molecular pain London : Sage, 2005 6(2010), 1 vom: 31. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:6 year:2010 number:1 day:31 month:05 https://dx.doi.org/10.1186/1744-8069-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1 31 05 |
| allfields_unstemmed |
10.1186/1744-8069-6-32 doi (DE-627)SPR029305578 (SPR)1744-8069-6-32-e DE-627 ger DE-627 rakwb eng Mobascher, Arian verfasserin aut The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mobascher et al; licensee BioMed Central Ltd. 2010 Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 Brinkmeyer, Juergen aut Thiele, Holger aut Toliat, Mohammad R aut Steffens, Michael aut Warbrick, Tracy aut Musso, Francesco aut Wittsack, Hans-Joerg aut Saleh, Andreas aut Schnitzler, Alfons aut Winterer, Georg aut Enthalten in Molecular pain London : Sage, 2005 6(2010), 1 vom: 31. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:6 year:2010 number:1 day:31 month:05 https://dx.doi.org/10.1186/1744-8069-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1 31 05 |
| allfieldsGer |
10.1186/1744-8069-6-32 doi (DE-627)SPR029305578 (SPR)1744-8069-6-32-e DE-627 ger DE-627 rakwb eng Mobascher, Arian verfasserin aut The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mobascher et al; licensee BioMed Central Ltd. 2010 Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 Brinkmeyer, Juergen aut Thiele, Holger aut Toliat, Mohammad R aut Steffens, Michael aut Warbrick, Tracy aut Musso, Francesco aut Wittsack, Hans-Joerg aut Saleh, Andreas aut Schnitzler, Alfons aut Winterer, Georg aut Enthalten in Molecular pain London : Sage, 2005 6(2010), 1 vom: 31. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:6 year:2010 number:1 day:31 month:05 https://dx.doi.org/10.1186/1744-8069-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1 31 05 |
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10.1186/1744-8069-6-32 doi (DE-627)SPR029305578 (SPR)1744-8069-6-32-e DE-627 ger DE-627 rakwb eng Mobascher, Arian verfasserin aut The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mobascher et al; licensee BioMed Central Ltd. 2010 Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 Brinkmeyer, Juergen aut Thiele, Holger aut Toliat, Mohammad R aut Steffens, Michael aut Warbrick, Tracy aut Musso, Francesco aut Wittsack, Hans-Joerg aut Saleh, Andreas aut Schnitzler, Alfons aut Winterer, Georg aut Enthalten in Molecular pain London : Sage, 2005 6(2010), 1 vom: 31. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:6 year:2010 number:1 day:31 month:05 https://dx.doi.org/10.1186/1744-8069-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2010 1 31 05 |
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The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation Anterior Cingulate Cortex (dpeaa)DE-He213 Pain Processing (dpeaa)DE-He213 Bold Activation (dpeaa)DE-He213 Dorsal Anterior Cingulate Cortex (dpeaa)DE-He213 COMT Genotype (dpeaa)DE-He213 |
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$ val^{158} $met polymorphism of human catechol-o-methyltransferase (comt) affects anterior cingulate cortex activation in response to painful laser stimulation |
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The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation |
| abstract |
Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. © Mobascher et al; licensee BioMed Central Ltd. 2010 |
| abstractGer |
Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. © Mobascher et al; licensee BioMed Central Ltd. 2010 |
| abstract_unstemmed |
Background Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional μ-opioid system responses to painful stimulation as measured by ligand-PET (positron emission tomography). The functional $ val^{158} $met single nucleotide polymorphism has been most widely studied. However, apart from its impact on pain-induced opioid release the effect of this genetic variation on cerebral pain processing has not been studied with activation measures such as functional magnetic resonance imaging (fMRI), PET or electroencephalography. In the present fMRI study we therefore sought to investigate the impact of the COMT $ val^{158} $met polymorphism on the blood oxygen level-dependent (BOLD) response to painful laser stimulation. Results 57 subjects were studied. We found that subjects homozygous for the met158 allele exhibit a higher BOLD response in the anterior cingulate cortex (ACC), foremost in the mid-cingulate cortex, than carriers of the val158 allele. Conclusion This result is in line with previous studies that reported higher pain sensitivity in homozygous met carriers. It adds to the current literature in suggesting that this behavioral phenotype may be mediated by, or is at least associated with, increased ACC activity. More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT $ val^{158} $met polymorphism on cerebral pain processing. © Mobascher et al; licensee BioMed Central Ltd. 2010 |
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The $ val^{158} $met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation |
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https://dx.doi.org/10.1186/1744-8069-6-32 |
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| author2 |
Brinkmeyer, Juergen Thiele, Holger Toliat, Mohammad R Steffens, Michael Warbrick, Tracy Musso, Francesco Wittsack, Hans-Joerg Saleh, Andreas Schnitzler, Alfons Winterer, Georg |
| author2Str |
Brinkmeyer, Juergen Thiele, Holger Toliat, Mohammad R Steffens, Michael Warbrick, Tracy Musso, Francesco Wittsack, Hans-Joerg Saleh, Andreas Schnitzler, Alfons Winterer, Georg |
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