Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice

Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the presen...
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Autor*in:	Song, Qian [verfasserIn] Liu, Ming-Gang Zhuo, Min

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Minocycline Multi-electrode array Presynaptic long-term potentiation Postsynaptic long-term potentiation Anterior cingulate cortex

Anmerkung:	© Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Molecular pain - London : Sage, 2005, 11(2015), 1 vom: 02. Mai
Übergeordnetes Werk:	volume:11 ; year:2015 ; number:1 ; day:02 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s12990-015-0025-2

Katalog-ID:	SPR029310563

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allfields	10.1186/s12990-015-0025-2 doi (DE-627)SPR029310563 (SPR)s12990-015-0025-2-e DE-627 ger DE-627 rakwb eng Song, Qian verfasserin aut Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213 Liu, Ming-Gang aut Zhuo, Min aut Enthalten in Molecular pain London : Sage, 2005 11(2015), 1 vom: 02. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:11 year:2015 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12990-015-0025-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 02 05
spelling	10.1186/s12990-015-0025-2 doi (DE-627)SPR029310563 (SPR)s12990-015-0025-2-e DE-627 ger DE-627 rakwb eng Song, Qian verfasserin aut Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213 Liu, Ming-Gang aut Zhuo, Min aut Enthalten in Molecular pain London : Sage, 2005 11(2015), 1 vom: 02. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:11 year:2015 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12990-015-0025-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 02 05
allfields_unstemmed	10.1186/s12990-015-0025-2 doi (DE-627)SPR029310563 (SPR)s12990-015-0025-2-e DE-627 ger DE-627 rakwb eng Song, Qian verfasserin aut Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213 Liu, Ming-Gang aut Zhuo, Min aut Enthalten in Molecular pain London : Sage, 2005 11(2015), 1 vom: 02. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:11 year:2015 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12990-015-0025-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 02 05
allfieldsGer	10.1186/s12990-015-0025-2 doi (DE-627)SPR029310563 (SPR)s12990-015-0025-2-e DE-627 ger DE-627 rakwb eng Song, Qian verfasserin aut Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213 Liu, Ming-Gang aut Zhuo, Min aut Enthalten in Molecular pain London : Sage, 2005 11(2015), 1 vom: 02. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:11 year:2015 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12990-015-0025-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 02 05
allfieldsSound	10.1186/s12990-015-0025-2 doi (DE-627)SPR029310563 (SPR)s12990-015-0025-2-e DE-627 ger DE-627 rakwb eng Song, Qian verfasserin aut Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213 Liu, Ming-Gang aut Zhuo, Min aut Enthalten in Molecular pain London : Sage, 2005 11(2015), 1 vom: 02. Mai (DE-627)47753368X (DE-600)2174252-2 1744-8069 nnns volume:11 year:2015 number:1 day:02 month:05 https://dx.doi.org/10.1186/s12990-015-0025-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2704 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2015 1 02 05
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topic_facet	Minocycline Multi-electrode array Presynaptic long-term potentiation Postsynaptic long-term potentiation Anterior cingulate cortex
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container_title	Molecular pain
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author	Song, Qian
spellingShingle	Song, Qian misc Minocycline misc Multi-electrode array misc Presynaptic long-term potentiation misc Postsynaptic long-term potentiation misc Anterior cingulate cortex Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
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topic_title	Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice Minocycline (dpeaa)DE-He213 Multi-electrode array (dpeaa)DE-He213 Presynaptic long-term potentiation (dpeaa)DE-He213 Postsynaptic long-term potentiation (dpeaa)DE-He213 Anterior cingulate cortex (dpeaa)DE-He213
topic	misc Minocycline misc Multi-electrode array misc Presynaptic long-term potentiation misc Postsynaptic long-term potentiation misc Anterior cingulate cortex
topic_unstemmed	misc Minocycline misc Multi-electrode array misc Presynaptic long-term potentiation misc Postsynaptic long-term potentiation misc Anterior cingulate cortex
topic_browse	misc Minocycline misc Multi-electrode array misc Presynaptic long-term potentiation misc Postsynaptic long-term potentiation misc Anterior cingulate cortex
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title	Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
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title_full	Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
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title_sort	minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
title_auth	Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
abstract	Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract It has been reported that activated microglia plays important roles in chronic pain-related sensory signaling at the spinal cord dorsal horn. Less is known about the possible contribution of microglia to cortical plasticity that has been found to be important for chronic pain. In the present study, we used a 64-channel multi-electrode array recording system to investigate the role of microglia in cortical plasticity of the anterior cingulate cortex (ACC) in normal adult mice. We found that bath application of minocycline, an inhibitor of microglial activation, had no effect on postsynaptic LTP (post-LTP) induced by theta burst stimulation in the ACC. Furthermore, presynaptic LTP (pre-LTP) induced by the combination of low-frequency stimulation with a GluK1-containing kainate receptor agonist was also not affected. The spatial distribution of post-LTP or pre-LTP among the cingulate network is also unaltered by minocycline. Our results suggest that minocycline does not affect cingulate plasticity and neurons are the major player in pain-related cortical plasticity. © Song et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice
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Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice

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