Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia

Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allel...
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Autor*in:	Datta, Susmita R [verfasserIn] McQuillin, Andrew Puri, Vinay Choudhury, Khalid Thirumalai, Srinivasa Lawrence, Jacob Pimm, Jonathan Bass, Nicholas Lamb, Graham Moorey, Helen Morgan, Jenny Punukollu, Bhaskar Kandasami, Gomathinayagam Kirwin, Simon Sule, Akeem Quested, Digby Curtis, David Gurling, Hugh MD

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Schizophrenia Allelic Association Risk Haplotype Haplotypic Association Family Sample

Anmerkung:	© Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Behavioral and brain functions - London : BioMed Central, 2005, 3(2007), 1 vom: 23. Sept.
Übergeordnetes Werk:	volume:3 ; year:2007 ; number:1 ; day:23 ; month:09

Links:	Volltext

DOI / URN:	10.1186/1744-9081-3-50

Katalog-ID:	SPR029339200

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520			\|a Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family.
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allfields	10.1186/1744-9081-3-50 doi (DE-627)SPR029339200 (SPR)1744-9081-3-50-e DE-627 ger DE-627 rakwb eng Datta, Susmita R verfasserin aut Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213 McQuillin, Andrew aut Puri, Vinay aut Choudhury, Khalid aut Thirumalai, Srinivasa aut Lawrence, Jacob aut Pimm, Jonathan aut Bass, Nicholas aut Lamb, Graham aut Moorey, Helen aut Morgan, Jenny aut Punukollu, Bhaskar aut Kandasami, Gomathinayagam aut Kirwin, Simon aut Sule, Akeem aut Quested, Digby aut Curtis, David aut Gurling, Hugh MD aut Enthalten in Behavioral and brain functions London : BioMed Central, 2005 3(2007), 1 vom: 23. Sept. (DE-627)484836994 (DE-600)2185773-8 1744-9081 nnns volume:3 year:2007 number:1 day:23 month:09 https://dx.doi.org/10.1186/1744-9081-3-50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 1 23 09
spelling	10.1186/1744-9081-3-50 doi (DE-627)SPR029339200 (SPR)1744-9081-3-50-e DE-627 ger DE-627 rakwb eng Datta, Susmita R verfasserin aut Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213 McQuillin, Andrew aut Puri, Vinay aut Choudhury, Khalid aut Thirumalai, Srinivasa aut Lawrence, Jacob aut Pimm, Jonathan aut Bass, Nicholas aut Lamb, Graham aut Moorey, Helen aut Morgan, Jenny aut Punukollu, Bhaskar aut Kandasami, Gomathinayagam aut Kirwin, Simon aut Sule, Akeem aut Quested, Digby aut Curtis, David aut Gurling, Hugh MD aut Enthalten in Behavioral and brain functions London : BioMed Central, 2005 3(2007), 1 vom: 23. Sept. (DE-627)484836994 (DE-600)2185773-8 1744-9081 nnns volume:3 year:2007 number:1 day:23 month:09 https://dx.doi.org/10.1186/1744-9081-3-50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 1 23 09
allfields_unstemmed	10.1186/1744-9081-3-50 doi (DE-627)SPR029339200 (SPR)1744-9081-3-50-e DE-627 ger DE-627 rakwb eng Datta, Susmita R verfasserin aut Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213 McQuillin, Andrew aut Puri, Vinay aut Choudhury, Khalid aut Thirumalai, Srinivasa aut Lawrence, Jacob aut Pimm, Jonathan aut Bass, Nicholas aut Lamb, Graham aut Moorey, Helen aut Morgan, Jenny aut Punukollu, Bhaskar aut Kandasami, Gomathinayagam aut Kirwin, Simon aut Sule, Akeem aut Quested, Digby aut Curtis, David aut Gurling, Hugh MD aut Enthalten in Behavioral and brain functions London : BioMed Central, 2005 3(2007), 1 vom: 23. Sept. (DE-627)484836994 (DE-600)2185773-8 1744-9081 nnns volume:3 year:2007 number:1 day:23 month:09 https://dx.doi.org/10.1186/1744-9081-3-50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 1 23 09
allfieldsGer	10.1186/1744-9081-3-50 doi (DE-627)SPR029339200 (SPR)1744-9081-3-50-e DE-627 ger DE-627 rakwb eng Datta, Susmita R verfasserin aut Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213 McQuillin, Andrew aut Puri, Vinay aut Choudhury, Khalid aut Thirumalai, Srinivasa aut Lawrence, Jacob aut Pimm, Jonathan aut Bass, Nicholas aut Lamb, Graham aut Moorey, Helen aut Morgan, Jenny aut Punukollu, Bhaskar aut Kandasami, Gomathinayagam aut Kirwin, Simon aut Sule, Akeem aut Quested, Digby aut Curtis, David aut Gurling, Hugh MD aut Enthalten in Behavioral and brain functions London : BioMed Central, 2005 3(2007), 1 vom: 23. Sept. (DE-627)484836994 (DE-600)2185773-8 1744-9081 nnns volume:3 year:2007 number:1 day:23 month:09 https://dx.doi.org/10.1186/1744-9081-3-50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 1 23 09
allfieldsSound	10.1186/1744-9081-3-50 doi (DE-627)SPR029339200 (SPR)1744-9081-3-50-e DE-627 ger DE-627 rakwb eng Datta, Susmita R verfasserin aut Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213 McQuillin, Andrew aut Puri, Vinay aut Choudhury, Khalid aut Thirumalai, Srinivasa aut Lawrence, Jacob aut Pimm, Jonathan aut Bass, Nicholas aut Lamb, Graham aut Moorey, Helen aut Morgan, Jenny aut Punukollu, Bhaskar aut Kandasami, Gomathinayagam aut Kirwin, Simon aut Sule, Akeem aut Quested, Digby aut Curtis, David aut Gurling, Hugh MD aut Enthalten in Behavioral and brain functions London : BioMed Central, 2005 3(2007), 1 vom: 23. Sept. (DE-627)484836994 (DE-600)2185773-8 1744-9081 nnns volume:3 year:2007 number:1 day:23 month:09 https://dx.doi.org/10.1186/1744-9081-3-50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2007 1 23 09
language	English
source	Enthalten in Behavioral and brain functions 3(2007), 1 vom: 23. Sept. volume:3 year:2007 number:1 day:23 month:09
sourceStr	Enthalten in Behavioral and brain functions 3(2007), 1 vom: 23. Sept. volume:3 year:2007 number:1 day:23 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Schizophrenia Allelic Association Risk Haplotype Haplotypic Association Family Sample
isfreeaccess_bool	false
container_title	Behavioral and brain functions
authorswithroles_txt_mv	Datta, Susmita R @@aut@@ McQuillin, Andrew @@aut@@ Puri, Vinay @@aut@@ Choudhury, Khalid @@aut@@ Thirumalai, Srinivasa @@aut@@ Lawrence, Jacob @@aut@@ Pimm, Jonathan @@aut@@ Bass, Nicholas @@aut@@ Lamb, Graham @@aut@@ Moorey, Helen @@aut@@ Morgan, Jenny @@aut@@ Punukollu, Bhaskar @@aut@@ Kandasami, Gomathinayagam @@aut@@ Kirwin, Simon @@aut@@ Sule, Akeem @@aut@@ Quested, Digby @@aut@@ Curtis, David @@aut@@ Gurling, Hugh MD @@aut@@
publishDateDaySort_date	2007-09-23T00:00:00Z
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author	Datta, Susmita R
spellingShingle	Datta, Susmita R misc Schizophrenia misc Allelic Association misc Risk Haplotype misc Haplotypic Association misc Family Sample Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
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topic_title	Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia Schizophrenia (dpeaa)DE-He213 Allelic Association (dpeaa)DE-He213 Risk Haplotype (dpeaa)DE-He213 Haplotypic Association (dpeaa)DE-He213 Family Sample (dpeaa)DE-He213
topic	misc Schizophrenia misc Allelic Association misc Risk Haplotype misc Haplotypic Association misc Family Sample
topic_unstemmed	misc Schizophrenia misc Allelic Association misc Risk Haplotype misc Haplotypic Association misc Family Sample
topic_browse	misc Schizophrenia misc Allelic Association misc Risk Haplotype misc Haplotypic Association misc Family Sample
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title	Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
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title_full	Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
author_sort	Datta, Susmita R
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author_browse	Datta, Susmita R McQuillin, Andrew Puri, Vinay Choudhury, Khalid Thirumalai, Srinivasa Lawrence, Jacob Pimm, Jonathan Bass, Nicholas Lamb, Graham Moorey, Helen Morgan, Jenny Punukollu, Bhaskar Kandasami, Gomathinayagam Kirwin, Simon Sule, Akeem Quested, Digby Curtis, David Gurling, Hugh MD
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author-letter	Datta, Susmita R
doi_str_mv	10.1186/1744-9081-3-50
title_sort	failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (dtnbp1) locus and schizophrenia
title_auth	Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
abstract	Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia. Methods We used the case control design to test for of allelic and haplotypic association with schizophrenia in a sample of four hundred and fifty research subjects with schizophrenia and four hundred and fifty ancestrally matched supernormal controls. We genotyped the SNP markers previously found to be significantly associated with schizophrenia in the original study and also other markers found to be positive in subsequent studies. Results We could find no evidence of allelic, genotypic or haplotypic association with schizophrenia in our UK sample. Conclusion The results suggest that the DTNBP1 gene contribution to schizophrenia must be rare or absent in our sample. The discrepant allelic association results in previous studies of association between DTNBP1 and schizophrenia could be due population admixture. However, even positive studies of European populations do not show any consistent DTNBP1 alleles or haplotypes associated with schizophrenia. Further research is needed to resolve these issues. The possible confounding of linkage with association in family samples already showing linkage at 6p22.3 might be revealed by testing genes closely linked to DTNBP1 for allelic association and by restricting family based tests of association to only one case per family. © Datta et al; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
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author2	McQuillin, Andrew Puri, Vinay Choudhury, Khalid Thirumalai, Srinivasa Lawrence, Jacob Pimm, Jonathan Bass, Nicholas Lamb, Graham Moorey, Helen Morgan, Jenny Punukollu, Bhaskar Kandasami, Gomathinayagam Kirwin, Simon Sule, Akeem Quested, Digby Curtis, David Gurling, Hugh MD
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Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia

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