Review of juxtaglomerular cell tumor with focus on pathobiological aspect

Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or g...
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Autor*in:	Kuroda, Naoto [verfasserIn] Gotoda, Hiroko Ohe, Chisato Mikami, Shuji Inoue, Keiji Nagashima, Yoji Petersson, Fredrik Alvarado-Cabrero, Isabel Pan, Chin-Chen Hes, Ondrej Michal, Michal Gatalica, Zoran

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Renin Partial Nephrectomy Urothelial Carcinoma Solitary Fibrous Tumor Glomus Tumor

Anmerkung:	© Kuroda et al; licensee BioMed Central Ltd. 2011

Übergeordnetes Werk:	Enthalten in: Diagnostic pathology - [S.l.] : BioMed Central, 2006, 6(2011), 1 vom: 26. Aug.
Übergeordnetes Werk:	volume:6 ; year:2011 ; number:1 ; day:26 ; month:08

Links:	Volltext

DOI / URN:	10.1186/1746-1596-6-80

Katalog-ID:	SPR029367018

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520			\|a Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases.
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allfields	10.1186/1746-1596-6-80 doi (DE-627)SPR029367018 (SPR)1746-1596-6-80-e DE-627 ger DE-627 rakwb eng Kuroda, Naoto verfasserin aut Review of juxtaglomerular cell tumor with focus on pathobiological aspect 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kuroda et al; licensee BioMed Central Ltd. 2011 Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213 Gotoda, Hiroko aut Ohe, Chisato aut Mikami, Shuji aut Inoue, Keiji aut Nagashima, Yoji aut Petersson, Fredrik aut Alvarado-Cabrero, Isabel aut Pan, Chin-Chen aut Hes, Ondrej aut Michal, Michal aut Gatalica, Zoran aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 6(2011), 1 vom: 26. Aug. (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:6 year:2011 number:1 day:26 month:08 https://dx.doi.org/10.1186/1746-1596-6-80 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 26 08
spelling	10.1186/1746-1596-6-80 doi (DE-627)SPR029367018 (SPR)1746-1596-6-80-e DE-627 ger DE-627 rakwb eng Kuroda, Naoto verfasserin aut Review of juxtaglomerular cell tumor with focus on pathobiological aspect 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kuroda et al; licensee BioMed Central Ltd. 2011 Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213 Gotoda, Hiroko aut Ohe, Chisato aut Mikami, Shuji aut Inoue, Keiji aut Nagashima, Yoji aut Petersson, Fredrik aut Alvarado-Cabrero, Isabel aut Pan, Chin-Chen aut Hes, Ondrej aut Michal, Michal aut Gatalica, Zoran aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 6(2011), 1 vom: 26. Aug. (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:6 year:2011 number:1 day:26 month:08 https://dx.doi.org/10.1186/1746-1596-6-80 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 26 08
allfields_unstemmed	10.1186/1746-1596-6-80 doi (DE-627)SPR029367018 (SPR)1746-1596-6-80-e DE-627 ger DE-627 rakwb eng Kuroda, Naoto verfasserin aut Review of juxtaglomerular cell tumor with focus on pathobiological aspect 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kuroda et al; licensee BioMed Central Ltd. 2011 Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213 Gotoda, Hiroko aut Ohe, Chisato aut Mikami, Shuji aut Inoue, Keiji aut Nagashima, Yoji aut Petersson, Fredrik aut Alvarado-Cabrero, Isabel aut Pan, Chin-Chen aut Hes, Ondrej aut Michal, Michal aut Gatalica, Zoran aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 6(2011), 1 vom: 26. Aug. (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:6 year:2011 number:1 day:26 month:08 https://dx.doi.org/10.1186/1746-1596-6-80 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 26 08
allfieldsGer	10.1186/1746-1596-6-80 doi (DE-627)SPR029367018 (SPR)1746-1596-6-80-e DE-627 ger DE-627 rakwb eng Kuroda, Naoto verfasserin aut Review of juxtaglomerular cell tumor with focus on pathobiological aspect 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kuroda et al; licensee BioMed Central Ltd. 2011 Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213 Gotoda, Hiroko aut Ohe, Chisato aut Mikami, Shuji aut Inoue, Keiji aut Nagashima, Yoji aut Petersson, Fredrik aut Alvarado-Cabrero, Isabel aut Pan, Chin-Chen aut Hes, Ondrej aut Michal, Michal aut Gatalica, Zoran aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 6(2011), 1 vom: 26. Aug. (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:6 year:2011 number:1 day:26 month:08 https://dx.doi.org/10.1186/1746-1596-6-80 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 26 08
allfieldsSound	10.1186/1746-1596-6-80 doi (DE-627)SPR029367018 (SPR)1746-1596-6-80-e DE-627 ger DE-627 rakwb eng Kuroda, Naoto verfasserin aut Review of juxtaglomerular cell tumor with focus on pathobiological aspect 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kuroda et al; licensee BioMed Central Ltd. 2011 Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213 Gotoda, Hiroko aut Ohe, Chisato aut Mikami, Shuji aut Inoue, Keiji aut Nagashima, Yoji aut Petersson, Fredrik aut Alvarado-Cabrero, Isabel aut Pan, Chin-Chen aut Hes, Ondrej aut Michal, Michal aut Gatalica, Zoran aut Enthalten in Diagnostic pathology [S.l.] : BioMed Central, 2006 6(2011), 1 vom: 26. Aug. (DE-627)503328960 (DE-600)2210518-9 1746-1596 nnns volume:6 year:2011 number:1 day:26 month:08 https://dx.doi.org/10.1186/1746-1596-6-80 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 26 08
language	English
source	Enthalten in Diagnostic pathology 6(2011), 1 vom: 26. Aug. volume:6 year:2011 number:1 day:26 month:08
sourceStr	Enthalten in Diagnostic pathology 6(2011), 1 vom: 26. Aug. volume:6 year:2011 number:1 day:26 month:08
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institution	findex.gbv.de
topic_facet	Renin Partial Nephrectomy Urothelial Carcinoma Solitary Fibrous Tumor Glomus Tumor
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container_title	Diagnostic pathology
authorswithroles_txt_mv	Kuroda, Naoto @@aut@@ Gotoda, Hiroko @@aut@@ Ohe, Chisato @@aut@@ Mikami, Shuji @@aut@@ Inoue, Keiji @@aut@@ Nagashima, Yoji @@aut@@ Petersson, Fredrik @@aut@@ Alvarado-Cabrero, Isabel @@aut@@ Pan, Chin-Chen @@aut@@ Hes, Ondrej @@aut@@ Michal, Michal @@aut@@ Gatalica, Zoran @@aut@@
publishDateDaySort_date	2011-08-26T00:00:00Z
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author	Kuroda, Naoto
spellingShingle	Kuroda, Naoto misc Renin misc Partial Nephrectomy misc Urothelial Carcinoma misc Solitary Fibrous Tumor misc Glomus Tumor Review of juxtaglomerular cell tumor with focus on pathobiological aspect
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topic_title	Review of juxtaglomerular cell tumor with focus on pathobiological aspect Renin (dpeaa)DE-He213 Partial Nephrectomy (dpeaa)DE-He213 Urothelial Carcinoma (dpeaa)DE-He213 Solitary Fibrous Tumor (dpeaa)DE-He213 Glomus Tumor (dpeaa)DE-He213
topic	misc Renin misc Partial Nephrectomy misc Urothelial Carcinoma misc Solitary Fibrous Tumor misc Glomus Tumor
topic_unstemmed	misc Renin misc Partial Nephrectomy misc Urothelial Carcinoma misc Solitary Fibrous Tumor misc Glomus Tumor
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author_browse	Kuroda, Naoto Gotoda, Hiroko Ohe, Chisato Mikami, Shuji Inoue, Keiji Nagashima, Yoji Petersson, Fredrik Alvarado-Cabrero, Isabel Pan, Chin-Chen Hes, Ondrej Michal, Michal Gatalica, Zoran
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title_sort	review of juxtaglomerular cell tumor with focus on pathobiological aspect
title_auth	Review of juxtaglomerular cell tumor with focus on pathobiological aspect
abstract	Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. © Kuroda et al; licensee BioMed Central Ltd. 2011
abstractGer	Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. © Kuroda et al; licensee BioMed Central Ltd. 2011
abstract_unstemmed	Abstract Juxtaglomerular cell tumor (JGCT) generally affects adolescents and young adults. The patients experience symptoms related to hypertension and hypokalemia due to renin-secretion by the tumor. Grossly, the tumor is well circumscribed with fibrous capsule and the cut surface shows yellow or gray-tan color with frequent hemorrhage. Histologically, the tumor is composed of monotonous polygonal cells with entrapped normal tubules. Immunohistochemically, tumor cells exhibit a positive reactivity for renin, vimentin and CD34. Ultrastructurally, neoplastic cells contain rhomboid-shaped renin protogranules. Genetically, losses of chromosomes 9 and 11 were frequently observed. Clinically, the majority of tumors showed a benign course, but rare tumors with vascular invasion or metastasis were reported. JGCT is a curable cause of hypertensive disease if it is discovered early and surgically removed, but may cause a fatal outcome usually by a cerebrovascular attack or may cause fetal demise in pregnancy. Additionally, pathologists and urologists need to recognize that this neoplasm in most cases pursues a benign course, but aggressive forms may develop in some cases. © Kuroda et al; licensee BioMed Central Ltd. 2011
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title_short	Review of juxtaglomerular cell tumor with focus on pathobiological aspect
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