The nature of fibrous dysplasia
Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit...
Ausführliche Beschreibung
Autor*in: |
Feller, Liviu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2009 |
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Anmerkung: |
© Feller et al; licensee BioMed Central Ltd. 2009 |
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Übergeordnetes Werk: |
Enthalten in: Head & face medicine - London : BioMed Central, 2005, 5(2009), 1 vom: 09. Nov. |
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Übergeordnetes Werk: |
volume:5 ; year:2009 ; number:1 ; day:09 ; month:11 |
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DOI / URN: |
10.1186/1746-160X-5-22 |
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Katalog-ID: |
SPR029394295 |
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10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11 |
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10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11 |
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10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11 |
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10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11 |
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10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11 |
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The nature of fibrous dysplasia Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 |
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Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009 |
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Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009 |
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Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009 |
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score |
7.398837 |