The nature of fibrous dysplasia

Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Feller, Liviu [verfasserIn] Wood, Neil H Khammissa, Razia AG Lemmer, Johan Raubenheimer, Erich J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Acromegaly Fibrous Dysplasia Osteogenic Cell Bony Lesion Craniofacial Bone

Anmerkung:	© Feller et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Head & face medicine - London : BioMed Central, 2005, 5(2009), 1 vom: 09. Nov.
Übergeordnetes Werk:	volume:5 ; year:2009 ; number:1 ; day:09 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1746-160X-5-22

Katalog-ID:	SPR029394295

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spelling	10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11
allfields_unstemmed	10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11
allfieldsGer	10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11
allfieldsSound	10.1186/1746-160X-5-22 doi (DE-627)SPR029394295 (SPR)1746-160X-5-22-e DE-627 ger DE-627 rakwb eng Feller, Liviu verfasserin aut The nature of fibrous dysplasia 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Feller et al; licensee BioMed Central Ltd. 2009 Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213 Wood, Neil H aut Khammissa, Razia AG aut Lemmer, Johan aut Raubenheimer, Erich J aut Enthalten in Head & face medicine London : BioMed Central, 2005 5(2009), 1 vom: 09. Nov. (DE-627)499547799 (DE-600)2202219-3 1746-160X nnns volume:5 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1746-160X-5-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2009 1 09 11
language	English
source	Enthalten in Head & face medicine 5(2009), 1 vom: 09. Nov. volume:5 year:2009 number:1 day:09 month:11
sourceStr	Enthalten in Head & face medicine 5(2009), 1 vom: 09. Nov. volume:5 year:2009 number:1 day:09 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acromegaly Fibrous Dysplasia Osteogenic Cell Bony Lesion Craniofacial Bone
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container_title	Head & face medicine
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spellingShingle	Feller, Liviu misc Acromegaly misc Fibrous Dysplasia misc Osteogenic Cell misc Bony Lesion misc Craniofacial Bone The nature of fibrous dysplasia
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topic_title	The nature of fibrous dysplasia Acromegaly (dpeaa)DE-He213 Fibrous Dysplasia (dpeaa)DE-He213 Osteogenic Cell (dpeaa)DE-He213 Bony Lesion (dpeaa)DE-He213 Craniofacial Bone (dpeaa)DE-He213
topic	misc Acromegaly misc Fibrous Dysplasia misc Osteogenic Cell misc Bony Lesion misc Craniofacial Bone
topic_unstemmed	misc Acromegaly misc Fibrous Dysplasia misc Osteogenic Cell misc Bony Lesion misc Craniofacial Bone
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title	The nature of fibrous dysplasia
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title_full	The nature of fibrous dysplasia
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author_browse	Feller, Liviu Wood, Neil H Khammissa, Razia AG Lemmer, Johan Raubenheimer, Erich J
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title_sort	nature of fibrous dysplasia
title_auth	The nature of fibrous dysplasia
abstract	Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009
abstractGer	Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsα subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. © Feller et al; licensee BioMed Central Ltd. 2009
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title_short	The nature of fibrous dysplasia
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Vorhandene Bände

Nicht das Richtige dabei?