Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?

Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV)...
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Autor*in:	Cioffi, Giovanni [verfasserIn] Tomasi, Cesare Rossi, Andrea Nistri, Stefano Tarantini, Luigi Faden, Giacomo Mazzone, Carmine Di Lenarda, Andrea Ettori, Federica Stefenelli, Carlo Faggiano, Pompilio

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Aortic stenosis Aortic valve replacement TAVI Balloon aortic valvuloplasty Prognosis

Anmerkung:	© Cioffi et al.; licensee BioMed Central. 2015

Übergeordnetes Werk:	Enthalten in: Cardiovascular ultrasound - London : Biomed Central, 2003, 13(2015), 1 vom: 09. Jan.
Übergeordnetes Werk:	volume:13 ; year:2015 ; number:1 ; day:09 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1476-7120-13-2

Katalog-ID:	SPR029441749

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520			\|a Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS.
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allfields	10.1186/1476-7120-13-2 doi (DE-627)SPR029441749 (SPR)1476-7120-13-2-e DE-627 ger DE-627 rakwb eng Cioffi, Giovanni verfasserin aut Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cioffi et al.; licensee BioMed Central. 2015 Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Tomasi, Cesare aut Rossi, Andrea aut Nistri, Stefano aut Tarantini, Luigi aut Faden, Giacomo aut Mazzone, Carmine aut Di Lenarda, Andrea aut Ettori, Federica aut Stefenelli, Carlo aut Faggiano, Pompilio aut Enthalten in Cardiovascular ultrasound London : Biomed Central, 2003 13(2015), 1 vom: 09. Jan. (DE-627)363752625 (DE-600)2105610-9 1476-7120 nnns volume:13 year:2015 number:1 day:09 month:01 https://dx.doi.org/10.1186/1476-7120-13-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 09 01
spelling	10.1186/1476-7120-13-2 doi (DE-627)SPR029441749 (SPR)1476-7120-13-2-e DE-627 ger DE-627 rakwb eng Cioffi, Giovanni verfasserin aut Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cioffi et al.; licensee BioMed Central. 2015 Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Tomasi, Cesare aut Rossi, Andrea aut Nistri, Stefano aut Tarantini, Luigi aut Faden, Giacomo aut Mazzone, Carmine aut Di Lenarda, Andrea aut Ettori, Federica aut Stefenelli, Carlo aut Faggiano, Pompilio aut Enthalten in Cardiovascular ultrasound London : Biomed Central, 2003 13(2015), 1 vom: 09. Jan. (DE-627)363752625 (DE-600)2105610-9 1476-7120 nnns volume:13 year:2015 number:1 day:09 month:01 https://dx.doi.org/10.1186/1476-7120-13-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 09 01
allfields_unstemmed	10.1186/1476-7120-13-2 doi (DE-627)SPR029441749 (SPR)1476-7120-13-2-e DE-627 ger DE-627 rakwb eng Cioffi, Giovanni verfasserin aut Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cioffi et al.; licensee BioMed Central. 2015 Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Tomasi, Cesare aut Rossi, Andrea aut Nistri, Stefano aut Tarantini, Luigi aut Faden, Giacomo aut Mazzone, Carmine aut Di Lenarda, Andrea aut Ettori, Federica aut Stefenelli, Carlo aut Faggiano, Pompilio aut Enthalten in Cardiovascular ultrasound London : Biomed Central, 2003 13(2015), 1 vom: 09. Jan. (DE-627)363752625 (DE-600)2105610-9 1476-7120 nnns volume:13 year:2015 number:1 day:09 month:01 https://dx.doi.org/10.1186/1476-7120-13-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 09 01
allfieldsGer	10.1186/1476-7120-13-2 doi (DE-627)SPR029441749 (SPR)1476-7120-13-2-e DE-627 ger DE-627 rakwb eng Cioffi, Giovanni verfasserin aut Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cioffi et al.; licensee BioMed Central. 2015 Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Tomasi, Cesare aut Rossi, Andrea aut Nistri, Stefano aut Tarantini, Luigi aut Faden, Giacomo aut Mazzone, Carmine aut Di Lenarda, Andrea aut Ettori, Federica aut Stefenelli, Carlo aut Faggiano, Pompilio aut Enthalten in Cardiovascular ultrasound London : Biomed Central, 2003 13(2015), 1 vom: 09. Jan. (DE-627)363752625 (DE-600)2105610-9 1476-7120 nnns volume:13 year:2015 number:1 day:09 month:01 https://dx.doi.org/10.1186/1476-7120-13-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 09 01
allfieldsSound	10.1186/1476-7120-13-2 doi (DE-627)SPR029441749 (SPR)1476-7120-13-2-e DE-627 ger DE-627 rakwb eng Cioffi, Giovanni verfasserin aut Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Cioffi et al.; licensee BioMed Central. 2015 Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Tomasi, Cesare aut Rossi, Andrea aut Nistri, Stefano aut Tarantini, Luigi aut Faden, Giacomo aut Mazzone, Carmine aut Di Lenarda, Andrea aut Ettori, Federica aut Stefenelli, Carlo aut Faggiano, Pompilio aut Enthalten in Cardiovascular ultrasound London : Biomed Central, 2003 13(2015), 1 vom: 09. Jan. (DE-627)363752625 (DE-600)2105610-9 1476-7120 nnns volume:13 year:2015 number:1 day:09 month:01 https://dx.doi.org/10.1186/1476-7120-13-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2015 1 09 01
language	English
source	Enthalten in Cardiovascular ultrasound 13(2015), 1 vom: 09. Jan. volume:13 year:2015 number:1 day:09 month:01
sourceStr	Enthalten in Cardiovascular ultrasound 13(2015), 1 vom: 09. Jan. volume:13 year:2015 number:1 day:09 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Aortic stenosis Aortic valve replacement TAVI Balloon aortic valvuloplasty Prognosis
isfreeaccess_bool	true
container_title	Cardiovascular ultrasound
authorswithroles_txt_mv	Cioffi, Giovanni @@aut@@ Tomasi, Cesare @@aut@@ Rossi, Andrea @@aut@@ Nistri, Stefano @@aut@@ Tarantini, Luigi @@aut@@ Faden, Giacomo @@aut@@ Mazzone, Carmine @@aut@@ Di Lenarda, Andrea @@aut@@ Ettori, Federica @@aut@@ Stefenelli, Carlo @@aut@@ Faggiano, Pompilio @@aut@@
publishDateDaySort_date	2015-01-09T00:00:00Z
hierarchy_top_id	363752625
id	SPR029441749
language_de	englisch
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In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. 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author	Cioffi, Giovanni
spellingShingle	Cioffi, Giovanni misc Aortic stenosis misc Aortic valve replacement misc TAVI misc Balloon aortic valvuloplasty misc Prognosis Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
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topic_title	Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis? Aortic stenosis (dpeaa)DE-He213 Aortic valve replacement (dpeaa)DE-He213 TAVI (dpeaa)DE-He213 Balloon aortic valvuloplasty (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213
topic	misc Aortic stenosis misc Aortic valve replacement misc TAVI misc Balloon aortic valvuloplasty misc Prognosis
topic_unstemmed	misc Aortic stenosis misc Aortic valve replacement misc TAVI misc Balloon aortic valvuloplasty misc Prognosis
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title	Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
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title_full	Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
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author_browse	Cioffi, Giovanni Tomasi, Cesare Rossi, Andrea Nistri, Stefano Tarantini, Luigi Faden, Giacomo Mazzone, Carmine Di Lenarda, Andrea Ettori, Federica Stefenelli, Carlo Faggiano, Pompilio
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title_sort	does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
title_auth	Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
abstract	Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. © Cioffi et al.; licensee BioMed Central. 2015
abstractGer	Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. © Cioffi et al.; licensee BioMed Central. 2015
abstract_unstemmed	Objective Aortic valve replacement (AVR) is the standard therapy in patients with symptomatic aortic stenosis (AS). In high surgical risk patients, alternative therapeutic options to medical treatment (MT) such as trans-catheter aortic valve implantation (TAVI) or balloon aortic valvuloplasty (BAV) have been proposed. In this study we evaluated whether treatment assignment influences per se the prognosis of these subjects. Patients and methods Criteria for treatment assignment were based on patient’s clinical conditions, Logistic EuroSCORE and other co-morbidities ignored by EuroSCORE. Due to baseline clinical differences between patients with diverse treatment assignment, we used propensity score matching to achieve balance. Results 368 patients were studied: 141 underwent AVR, 127 TAVI, 49 BAV and 51 MT. 84 events (deaths for all causes) occurred during 14 months of follow-up: 11 AVR (8%), 26 TAVI (20%), 18 MT (35%), 29 BAV group (59%). Traditional Cox analysis identified treatment assignment as independent predictor of events (HR 1.82 [CI 1.10-3.25]) together with lower left ventricular ejection fraction, impaired renal function and history of heart failure. Matched Cox analysis by propensity score confirmed treatment assignment as an independent prognosticator of events (HR 1.90 [CI 1.27-2.85]), and showed similar rate events in TAVI and AVR patients, while it was significantly increased in BAV and MT patients. Conclusions Treatment assignment may influence outcome of symptomatic patients with AS. © Cioffi et al.; licensee BioMed Central. 2015
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title_short	Does treatment assignment influence the prognosis of patients with symptomatic severe aortic stenosis?
url	https://dx.doi.org/10.1186/1476-7120-13-2
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