Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy
Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among th...
Ausführliche Beschreibung
Autor*in: |
Tang, Wei [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2019 |
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Anmerkung: |
© The Author(s) 2019 |
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Übergeordnetes Werk: |
Enthalten in: Journal of nanobiotechnology - London : Biomed Central, 2003, 17(2019), 1 vom: 20. Mai |
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Übergeordnetes Werk: |
volume:17 ; year:2019 ; number:1 ; day:20 ; month:05 |
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DOI / URN: |
10.1186/s12951-019-0501-3 |
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Katalog-ID: |
SPR029461995 |
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520 | |a Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. | ||
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10.1186/s12951-019-0501-3 doi (DE-627)SPR029461995 (SPR)s12951-019-0501-3-e DE-627 ger DE-627 rakwb eng Tang, Wei verfasserin aut Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. Chemodynamic therapy (dpeaa)DE-He213 GSH (dpeaa)DE-He213 BSA-templated (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Gao, Hongbo aut Ni, Dalong aut Wang, QiFeng aut Gu, Bingxin aut He, Xinhong aut Peng, Weijun (orcid)0000-0002-2764-3044 aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 17(2019), 1 vom: 20. Mai (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:17 year:2019 number:1 day:20 month:05 https://dx.doi.org/10.1186/s12951-019-0501-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 20 05 |
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10.1186/s12951-019-0501-3 doi (DE-627)SPR029461995 (SPR)s12951-019-0501-3-e DE-627 ger DE-627 rakwb eng Tang, Wei verfasserin aut Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. Chemodynamic therapy (dpeaa)DE-He213 GSH (dpeaa)DE-He213 BSA-templated (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Gao, Hongbo aut Ni, Dalong aut Wang, QiFeng aut Gu, Bingxin aut He, Xinhong aut Peng, Weijun (orcid)0000-0002-2764-3044 aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 17(2019), 1 vom: 20. Mai (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:17 year:2019 number:1 day:20 month:05 https://dx.doi.org/10.1186/s12951-019-0501-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 20 05 |
allfields_unstemmed |
10.1186/s12951-019-0501-3 doi (DE-627)SPR029461995 (SPR)s12951-019-0501-3-e DE-627 ger DE-627 rakwb eng Tang, Wei verfasserin aut Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. Chemodynamic therapy (dpeaa)DE-He213 GSH (dpeaa)DE-He213 BSA-templated (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Gao, Hongbo aut Ni, Dalong aut Wang, QiFeng aut Gu, Bingxin aut He, Xinhong aut Peng, Weijun (orcid)0000-0002-2764-3044 aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 17(2019), 1 vom: 20. Mai (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:17 year:2019 number:1 day:20 month:05 https://dx.doi.org/10.1186/s12951-019-0501-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 20 05 |
allfieldsGer |
10.1186/s12951-019-0501-3 doi (DE-627)SPR029461995 (SPR)s12951-019-0501-3-e DE-627 ger DE-627 rakwb eng Tang, Wei verfasserin aut Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. Chemodynamic therapy (dpeaa)DE-He213 GSH (dpeaa)DE-He213 BSA-templated (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Gao, Hongbo aut Ni, Dalong aut Wang, QiFeng aut Gu, Bingxin aut He, Xinhong aut Peng, Weijun (orcid)0000-0002-2764-3044 aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 17(2019), 1 vom: 20. Mai (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:17 year:2019 number:1 day:20 month:05 https://dx.doi.org/10.1186/s12951-019-0501-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 20 05 |
allfieldsSound |
10.1186/s12951-019-0501-3 doi (DE-627)SPR029461995 (SPR)s12951-019-0501-3-e DE-627 ger DE-627 rakwb eng Tang, Wei verfasserin aut Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. Chemodynamic therapy (dpeaa)DE-He213 GSH (dpeaa)DE-He213 BSA-templated (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Gao, Hongbo aut Ni, Dalong aut Wang, QiFeng aut Gu, Bingxin aut He, Xinhong aut Peng, Weijun (orcid)0000-0002-2764-3044 aut Enthalten in Journal of nanobiotechnology London : Biomed Central, 2003 17(2019), 1 vom: 20. Mai (DE-627)362770328 (DE-600)2100022-0 1477-3155 nnns volume:17 year:2019 number:1 day:20 month:05 https://dx.doi.org/10.1186/s12951-019-0501-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 20 05 |
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Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. 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bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy |
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Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy |
abstract |
Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. © The Author(s) 2019 |
abstractGer |
Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. © The Author(s) 2019 |
abstract_unstemmed |
Background Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide ($ H_{2} %$ O_{2} $). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI. © The Author(s) 2019 |
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Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy |
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Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT. Results In this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The $ Cu^{2+} $ in the CuS:Gd NPs could be reduced to $ Cu^{+} $ by GSH in tumors, which further reacted with $ H_{2} %$ O_{2} $ and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the $ Gd^{3+} $ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily. Conclusions The designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemodynamic therapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GSH</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">BSA-templated</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MRI</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gao, Hongbo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ni, Dalong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, QiFeng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gu, Bingxin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">He, Xinhong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peng, Weijun</subfield><subfield code="0">(orcid)0000-0002-2764-3044</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of nanobiotechnology</subfield><subfield code="d">London : Biomed Central, 2003</subfield><subfield code="g">17(2019), 1 vom: 20. 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