Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma
Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chou, Hsiu-Chuan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Anmerkung: |
© Chou and Chan; licensee BioMed Central Ltd. 2014 |
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| Übergeordnetes Werk: |
Enthalten in: Proteome science - London : BioMed Central, 2003, 12(2014), 1 vom: 09. Jan. |
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| Übergeordnetes Werk: |
volume:12 ; year:2014 ; number:1 ; day:09 ; month:01 |
| Links: |
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| DOI / URN: |
10.1186/1477-5956-12-2 |
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| Katalog-ID: |
SPR029470862 |
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| 520 | |a Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. | ||
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10.1186/1477-5956-12-2 doi (DE-627)SPR029470862 (SPR)1477-5956-12-2-e DE-627 ger DE-627 rakwb eng Chou, Hsiu-Chuan verfasserin aut Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chou and Chan; licensee BioMed Central Ltd. 2014 Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. Glutathione reductase (dpeaa)DE-He213 Proteomics (dpeaa)DE-He213 Redox-proteomics (dpeaa)DE-He213 2D-DIGE (dpeaa)DE-He213 MALDI-TOF MS (dpeaa)DE-He213 Chan, Hong-Lin aut Enthalten in Proteome science London : BioMed Central, 2003 12(2014), 1 vom: 09. Jan. (DE-627)383961440 (DE-600)2141087-2 1477-5956 nnns volume:12 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1477-5956-12-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 1 09 01 |
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10.1186/1477-5956-12-2 doi (DE-627)SPR029470862 (SPR)1477-5956-12-2-e DE-627 ger DE-627 rakwb eng Chou, Hsiu-Chuan verfasserin aut Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chou and Chan; licensee BioMed Central Ltd. 2014 Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. Glutathione reductase (dpeaa)DE-He213 Proteomics (dpeaa)DE-He213 Redox-proteomics (dpeaa)DE-He213 2D-DIGE (dpeaa)DE-He213 MALDI-TOF MS (dpeaa)DE-He213 Chan, Hong-Lin aut Enthalten in Proteome science London : BioMed Central, 2003 12(2014), 1 vom: 09. Jan. (DE-627)383961440 (DE-600)2141087-2 1477-5956 nnns volume:12 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1477-5956-12-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 1 09 01 |
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10.1186/1477-5956-12-2 doi (DE-627)SPR029470862 (SPR)1477-5956-12-2-e DE-627 ger DE-627 rakwb eng Chou, Hsiu-Chuan verfasserin aut Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chou and Chan; licensee BioMed Central Ltd. 2014 Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. Glutathione reductase (dpeaa)DE-He213 Proteomics (dpeaa)DE-He213 Redox-proteomics (dpeaa)DE-He213 2D-DIGE (dpeaa)DE-He213 MALDI-TOF MS (dpeaa)DE-He213 Chan, Hong-Lin aut Enthalten in Proteome science London : BioMed Central, 2003 12(2014), 1 vom: 09. Jan. (DE-627)383961440 (DE-600)2141087-2 1477-5956 nnns volume:12 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1477-5956-12-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 1 09 01 |
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10.1186/1477-5956-12-2 doi (DE-627)SPR029470862 (SPR)1477-5956-12-2-e DE-627 ger DE-627 rakwb eng Chou, Hsiu-Chuan verfasserin aut Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chou and Chan; licensee BioMed Central Ltd. 2014 Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. Glutathione reductase (dpeaa)DE-He213 Proteomics (dpeaa)DE-He213 Redox-proteomics (dpeaa)DE-He213 2D-DIGE (dpeaa)DE-He213 MALDI-TOF MS (dpeaa)DE-He213 Chan, Hong-Lin aut Enthalten in Proteome science London : BioMed Central, 2003 12(2014), 1 vom: 09. Jan. (DE-627)383961440 (DE-600)2141087-2 1477-5956 nnns volume:12 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1477-5956-12-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 1 09 01 |
| allfieldsSound |
10.1186/1477-5956-12-2 doi (DE-627)SPR029470862 (SPR)1477-5956-12-2-e DE-627 ger DE-627 rakwb eng Chou, Hsiu-Chuan verfasserin aut Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chou and Chan; licensee BioMed Central Ltd. 2014 Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. Glutathione reductase (dpeaa)DE-He213 Proteomics (dpeaa)DE-He213 Redox-proteomics (dpeaa)DE-He213 2D-DIGE (dpeaa)DE-He213 MALDI-TOF MS (dpeaa)DE-He213 Chan, Hong-Lin aut Enthalten in Proteome science London : BioMed Central, 2003 12(2014), 1 vom: 09. Jan. (DE-627)383961440 (DE-600)2141087-2 1477-5956 nnns volume:12 year:2014 number:1 day:09 month:01 https://dx.doi.org/10.1186/1477-5956-12-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2014 1 09 01 |
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However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. 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effect of glutathione reductase knockdown in response to uvb-induced oxidative stress in human lung adenocarcinoma |
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Effect of glutathione reductase knockdown in response to UVB-induced oxidative stress in human lung adenocarcinoma |
| abstract |
Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. © Chou and Chan; licensee BioMed Central Ltd. 2014 |
| abstractGer |
Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. © Chou and Chan; licensee BioMed Central Ltd. 2014 |
| abstract_unstemmed |
Background Glutathione reductase (GR) plays a critical role in the maintenance of physiological redox status in cells. However, the comprehensive investigations of GR-modulated oxidative stress have not been reported. Methods In the present study, we cultured a human lung adenocarcinoma line CL1-0 and its GR-knockdown derivative CL1-0ΔGR to evaluate their differential responses to UVB-irradiation. Results We identified 18 proteins that showed significant changes under UVB-irradiation in CL1-0ΔGR cells rather than in CL1-0 cells. Several proteins involving protein folding, metabolism, protein biosynthesis and redox regulation showed significant changes in expression. Conclusions In summary, the current study used a comprehensive lung adenocarcinoma-based proteomic approach for the identification of GR-modulated protein expression in response to UVB-irradiation. To our knowledge, this is the first global proteomic analysis to investigate the role of GR under UVB-irradiation in mammalian cell model. © Chou and Chan; licensee BioMed Central Ltd. 2014 |
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| score |
7.402693 |