Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy

Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurren...
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Autor*in:	Pellizzon, Antonio CassioAssis [verfasserIn] Salvajoli, João Victor Kowalski, Luiz Paulo Carvalho, Andre Lopes

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2006

Schlagwörter:	Biological Effective Dose Mobile Tongue Soft Tissue Necrosis Cervical Recurrence High Biological Effective Dose

Anmerkung:	© Pellizzon et al; licensee BioMed Central Ltd. 2006

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 1(2006), 1 vom: 08. Aug.
Übergeordnetes Werk:	volume:1 ; year:2006 ; number:1 ; day:08 ; month:08

Links:	Volltext

DOI / URN:	10.1186/1748-717X-1-27

Katalog-ID:	SPR029553970

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520			\|a Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery.
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allfields	10.1186/1748-717X-1-27 doi (DE-627)SPR029553970 (SPR)1748-717X-1-27-e DE-627 ger DE-627 rakwb eng Pellizzon, Antonio CassioAssis verfasserin aut Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pellizzon et al; licensee BioMed Central Ltd. 2006 Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213 Salvajoli, João Victor aut Kowalski, Luiz Paulo aut Carvalho, Andre Lopes aut Enthalten in Radiation oncology London : BioMed Central, 2006 1(2006), 1 vom: 08. Aug. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:1 year:2006 number:1 day:08 month:08 https://dx.doi.org/10.1186/1748-717X-1-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2006 1 08 08
spelling	10.1186/1748-717X-1-27 doi (DE-627)SPR029553970 (SPR)1748-717X-1-27-e DE-627 ger DE-627 rakwb eng Pellizzon, Antonio CassioAssis verfasserin aut Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pellizzon et al; licensee BioMed Central Ltd. 2006 Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213 Salvajoli, João Victor aut Kowalski, Luiz Paulo aut Carvalho, Andre Lopes aut Enthalten in Radiation oncology London : BioMed Central, 2006 1(2006), 1 vom: 08. Aug. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:1 year:2006 number:1 day:08 month:08 https://dx.doi.org/10.1186/1748-717X-1-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2006 1 08 08
allfields_unstemmed	10.1186/1748-717X-1-27 doi (DE-627)SPR029553970 (SPR)1748-717X-1-27-e DE-627 ger DE-627 rakwb eng Pellizzon, Antonio CassioAssis verfasserin aut Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pellizzon et al; licensee BioMed Central Ltd. 2006 Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213 Salvajoli, João Victor aut Kowalski, Luiz Paulo aut Carvalho, Andre Lopes aut Enthalten in Radiation oncology London : BioMed Central, 2006 1(2006), 1 vom: 08. Aug. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:1 year:2006 number:1 day:08 month:08 https://dx.doi.org/10.1186/1748-717X-1-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2006 1 08 08
allfieldsGer	10.1186/1748-717X-1-27 doi (DE-627)SPR029553970 (SPR)1748-717X-1-27-e DE-627 ger DE-627 rakwb eng Pellizzon, Antonio CassioAssis verfasserin aut Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pellizzon et al; licensee BioMed Central Ltd. 2006 Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213 Salvajoli, João Victor aut Kowalski, Luiz Paulo aut Carvalho, Andre Lopes aut Enthalten in Radiation oncology London : BioMed Central, 2006 1(2006), 1 vom: 08. Aug. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:1 year:2006 number:1 day:08 month:08 https://dx.doi.org/10.1186/1748-717X-1-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2006 1 08 08
allfieldsSound	10.1186/1748-717X-1-27 doi (DE-627)SPR029553970 (SPR)1748-717X-1-27-e DE-627 ger DE-627 rakwb eng Pellizzon, Antonio CassioAssis verfasserin aut Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pellizzon et al; licensee BioMed Central Ltd. 2006 Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213 Salvajoli, João Victor aut Kowalski, Luiz Paulo aut Carvalho, Andre Lopes aut Enthalten in Radiation oncology London : BioMed Central, 2006 1(2006), 1 vom: 08. Aug. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:1 year:2006 number:1 day:08 month:08 https://dx.doi.org/10.1186/1748-717X-1-27 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2006 1 08 08
language	English
source	Enthalten in Radiation oncology 1(2006), 1 vom: 08. Aug. volume:1 year:2006 number:1 day:08 month:08
sourceStr	Enthalten in Radiation oncology 1(2006), 1 vom: 08. Aug. volume:1 year:2006 number:1 day:08 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Biological Effective Dose Mobile Tongue Soft Tissue Necrosis Cervical Recurrence High Biological Effective Dose
isfreeaccess_bool	true
container_title	Radiation oncology
authorswithroles_txt_mv	Pellizzon, Antonio CassioAssis @@aut@@ Salvajoli, João Victor @@aut@@ Kowalski, Luiz Paulo @@aut@@ Carvalho, Andre Lopes @@aut@@
publishDateDaySort_date	2006-08-08T00:00:00Z
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author	Pellizzon, Antonio CassioAssis
spellingShingle	Pellizzon, Antonio CassioAssis misc Biological Effective Dose misc Mobile Tongue misc Soft Tissue Necrosis misc Cervical Recurrence misc High Biological Effective Dose Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
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topic_title	Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy Biological Effective Dose (dpeaa)DE-He213 Mobile Tongue (dpeaa)DE-He213 Soft Tissue Necrosis (dpeaa)DE-He213 Cervical Recurrence (dpeaa)DE-He213 High Biological Effective Dose (dpeaa)DE-He213
topic	misc Biological Effective Dose misc Mobile Tongue misc Soft Tissue Necrosis misc Cervical Recurrence misc High Biological Effective Dose
topic_unstemmed	misc Biological Effective Dose misc Mobile Tongue misc Soft Tissue Necrosis misc Cervical Recurrence misc High Biological Effective Dose
topic_browse	misc Biological Effective Dose misc Mobile Tongue misc Soft Tissue Necrosis misc Cervical Recurrence misc High Biological Effective Dose
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title	Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
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title_full	Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
author_sort	Pellizzon, Antonio CassioAssis
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author_browse	Pellizzon, Antonio CassioAssis Salvajoli, João Victor Kowalski, Luiz Paulo Carvalho, Andre Lopes
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title_sort	salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
title_auth	Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
abstract	Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. © Pellizzon et al; licensee BioMed Central Ltd. 2006
abstractGer	Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. © Pellizzon et al; licensee BioMed Central Ltd. 2006
abstract_unstemmed	Abstract Salvage therapy in head and neck cancer (HNC) is a controversy issue and the literature is scarce regarding the use of interstitial high-dose rate brachytherapy (I-HDR) in HNC. We evaluated the long-term results of a treatment policy combining salvage surgery and I-HDR for cervical recurrences of HNC. Charts of 21 patients treated from 1994 to 2004 were reviewed. The crude local control rate for all patients was 52.4%. The 5- and 8-years overall (OS) and local relapse-free survival (LRFS) rates were 50%, 42.9%, 42.5% and 28.6%, respectively. The only predictive factor associated to LFRS and OS was negative margin status (p = 0.0007 and p = 0.0002). We conclude that complete surgery is mandatory for long term control and the doses given by brachytherapy are not high enough to compensate for microscopic residual disease after surgery. © Pellizzon et al; licensee BioMed Central Ltd. 2006
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title_short	Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy
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author2	Salvajoli, João Victor Kowalski, Luiz Paulo Carvalho, Andre Lopes
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Salvage for cervical recurrences of head and neck cancer with dissection and interstitial high dose rate brachytherapy

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