Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging

Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were...
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Autor*in:	Wong, Ching-yee O [verfasserIn] Schmidt, Joseph Bong, Jeffery S Chundru, Suyra Kestin, Larry Yan, Di Grills, Inga Gaskill, Marianne Cheng, Vincent Martinez, Alvaro A Fink-Bennett, Darlene

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Standard Uptake Value Primary Lung Cancer Maximum Standard Uptake Value Glucose Metabolic Rate Standard Uptake Value Change

Anmerkung:	© Wong et al; licensee BioMed Central Ltd. 2007

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 2(2007), 1 vom: 23. Mai
Übergeordnetes Werk:	volume:2 ; year:2007 ; number:1 ; day:23 ; month:05

Links:	Volltext

DOI / URN:	10.1186/1748-717X-2-18

Katalog-ID:	SPR029559073

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520			\|a Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone.
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allfields	10.1186/1748-717X-2-18 doi (DE-627)SPR029559073 (SPR)1748-717X-2-18-e DE-627 ger DE-627 rakwb eng Wong, Ching-yee O verfasserin aut Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wong et al; licensee BioMed Central Ltd. 2007 Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213 Schmidt, Joseph aut Bong, Jeffery S aut Chundru, Suyra aut Kestin, Larry aut Yan, Di aut Grills, Inga aut Gaskill, Marianne aut Cheng, Vincent aut Martinez, Alvaro A aut Fink-Bennett, Darlene aut Enthalten in Radiation oncology London : BioMed Central, 2006 2(2007), 1 vom: 23. Mai (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:2 year:2007 number:1 day:23 month:05 https://dx.doi.org/10.1186/1748-717X-2-18 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 1 23 05
spelling	10.1186/1748-717X-2-18 doi (DE-627)SPR029559073 (SPR)1748-717X-2-18-e DE-627 ger DE-627 rakwb eng Wong, Ching-yee O verfasserin aut Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wong et al; licensee BioMed Central Ltd. 2007 Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213 Schmidt, Joseph aut Bong, Jeffery S aut Chundru, Suyra aut Kestin, Larry aut Yan, Di aut Grills, Inga aut Gaskill, Marianne aut Cheng, Vincent aut Martinez, Alvaro A aut Fink-Bennett, Darlene aut Enthalten in Radiation oncology London : BioMed Central, 2006 2(2007), 1 vom: 23. Mai (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:2 year:2007 number:1 day:23 month:05 https://dx.doi.org/10.1186/1748-717X-2-18 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 1 23 05
allfields_unstemmed	10.1186/1748-717X-2-18 doi (DE-627)SPR029559073 (SPR)1748-717X-2-18-e DE-627 ger DE-627 rakwb eng Wong, Ching-yee O verfasserin aut Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wong et al; licensee BioMed Central Ltd. 2007 Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213 Schmidt, Joseph aut Bong, Jeffery S aut Chundru, Suyra aut Kestin, Larry aut Yan, Di aut Grills, Inga aut Gaskill, Marianne aut Cheng, Vincent aut Martinez, Alvaro A aut Fink-Bennett, Darlene aut Enthalten in Radiation oncology London : BioMed Central, 2006 2(2007), 1 vom: 23. Mai (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:2 year:2007 number:1 day:23 month:05 https://dx.doi.org/10.1186/1748-717X-2-18 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 1 23 05
allfieldsGer	10.1186/1748-717X-2-18 doi (DE-627)SPR029559073 (SPR)1748-717X-2-18-e DE-627 ger DE-627 rakwb eng Wong, Ching-yee O verfasserin aut Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wong et al; licensee BioMed Central Ltd. 2007 Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213 Schmidt, Joseph aut Bong, Jeffery S aut Chundru, Suyra aut Kestin, Larry aut Yan, Di aut Grills, Inga aut Gaskill, Marianne aut Cheng, Vincent aut Martinez, Alvaro A aut Fink-Bennett, Darlene aut Enthalten in Radiation oncology London : BioMed Central, 2006 2(2007), 1 vom: 23. Mai (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:2 year:2007 number:1 day:23 month:05 https://dx.doi.org/10.1186/1748-717X-2-18 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 1 23 05
allfieldsSound	10.1186/1748-717X-2-18 doi (DE-627)SPR029559073 (SPR)1748-717X-2-18-e DE-627 ger DE-627 rakwb eng Wong, Ching-yee O verfasserin aut Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Wong et al; licensee BioMed Central Ltd. 2007 Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213 Schmidt, Joseph aut Bong, Jeffery S aut Chundru, Suyra aut Kestin, Larry aut Yan, Di aut Grills, Inga aut Gaskill, Marianne aut Cheng, Vincent aut Martinez, Alvaro A aut Fink-Bennett, Darlene aut Enthalten in Radiation oncology London : BioMed Central, 2006 2(2007), 1 vom: 23. Mai (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:2 year:2007 number:1 day:23 month:05 https://dx.doi.org/10.1186/1748-717X-2-18 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2007 1 23 05
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Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. 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author	Wong, Ching-yee O
spellingShingle	Wong, Ching-yee O misc Standard Uptake Value misc Primary Lung Cancer misc Maximum Standard Uptake Value misc Glucose Metabolic Rate misc Standard Uptake Value Change Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
authorStr	Wong, Ching-yee O
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topic_title	Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging Standard Uptake Value (dpeaa)DE-He213 Primary Lung Cancer (dpeaa)DE-He213 Maximum Standard Uptake Value (dpeaa)DE-He213 Glucose Metabolic Rate (dpeaa)DE-He213 Standard Uptake Value Change (dpeaa)DE-He213
topic	misc Standard Uptake Value misc Primary Lung Cancer misc Maximum Standard Uptake Value misc Glucose Metabolic Rate misc Standard Uptake Value Change
topic_unstemmed	misc Standard Uptake Value misc Primary Lung Cancer misc Maximum Standard Uptake Value misc Glucose Metabolic Rate misc Standard Uptake Value Change
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title	Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
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title_full	Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
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author_browse	Wong, Ching-yee O Schmidt, Joseph Bong, Jeffery S Chundru, Suyra Kestin, Larry Yan, Di Grills, Inga Gaskill, Marianne Cheng, Vincent Martinez, Alvaro A Fink-Bennett, Darlene
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doi_str_mv	10.1186/1748-717X-2-18
title_sort	correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined f-18 fdg pet-ct imaging
title_auth	Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
abstract	Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. © Wong et al; licensee BioMed Central Ltd. 2007
abstractGer	Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. © Wong et al; licensee BioMed Central Ltd. 2007
abstract_unstemmed	Background To correlate the metabolic changes with size changes for tumor response by concomitant PET-CT evaluation of lung cancers after radiotherapy. Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone. © Wong et al; licensee BioMed Central Ltd. 2007
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title_short	Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging
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author2	Schmidt, Joseph Bong, Jeffery S Chundru, Suyra Kestin, Larry Yan, Di Grills, Inga Gaskill, Marianne Cheng, Vincent Martinez, Alvaro A Fink-Bennett, Darlene
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up_date	2024-07-04T01:28:39.561Z
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Methods 36 patients were studied pre- and post-radiotherapy $ with^{18} $FDG PET-CT scans at a median interval of 71 days. All of the patients were followed clinically and radiographically after a mean period of 342 days for assessment of local control or failure rates. Change in size (sum of maximum orthogonal diameters) was correlated with that of maximum standard uptake value (SUV) of the primary lung cancer before and after conventional radiotherapy. Results There was a significant reduction in both SUV and size of the primary cancer after radiotherapy (p < 0.00005). Among the 20 surviving patients, the sensitivity, specificity, and accuracy using PET (SUV) were 94%, 50%, 90% respectively and the corresponding values using and CT (size criteria) were 67%, 50%, and 65% respectively. The metabolic change (SUV) was highly correlated with the change in size by a quadratic function. In addition, the mean percentage metabolic change was significantly larger than that of size change (62.3 ± 32.7% vs 47.1 ± 26.1% respectively, p = 0.03) Conclusion Correlating and incorporating metabolic change by PET into size change by concomitant CT is more sensitive in assessing therapeutic response than CT alone.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Standard Uptake Value</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Primary Lung Cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Maximum Standard Uptake Value</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glucose Metabolic Rate</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Standard Uptake Value Change</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schmidt, Joseph</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bong, Jeffery S</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chundru, Suyra</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kestin, Larry</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yan, Di</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Grills, Inga</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gaskill, Marianne</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cheng, Vincent</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martinez, Alvaro A</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fink-Bennett, Darlene</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Radiation oncology</subfield><subfield code="d">London : BioMed Central, 2006</subfield><subfield code="g">2(2007), 1 vom: 23. 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Correlating metabolic and anatomic responses of primary lung cancers to radiotherapy by combined F-18 FDG PET-CT imaging

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