Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report

Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic sign...
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Autor*in:	Al Achkar, Walid [verfasserIn] Wafa, Abdulsamad Mkrtchyan, Hasmik Moassass, Faten Liehr, Thomas

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Imatinib Chronic Myeloid Leukemia Clonal Evolution Complex Translocation Variant Translocation

Anmerkung:	© Al Achkar et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Molecular cytogenetics - London : BioMed Central, 2008, 2(2009), 1 vom: 09. Nov.
Übergeordnetes Werk:	volume:2 ; year:2009 ; number:1 ; day:09 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1755-8166-2-21

Katalog-ID:	SPR029575923

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520			\|a Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment.
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allfields	10.1186/1755-8166-2-21 doi (DE-627)SPR029575923 (SPR)1755-8166-2-21-e DE-627 ger DE-627 rakwb eng Al Achkar, Walid verfasserin aut Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Al Achkar et al; licensee BioMed Central Ltd. 2009 Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213 Wafa, Abdulsamad aut Mkrtchyan, Hasmik aut Moassass, Faten aut Liehr, Thomas aut Enthalten in Molecular cytogenetics London : BioMed Central, 2008 2(2009), 1 vom: 09. Nov. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:2 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1755-8166-2-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1 09 11
spelling	10.1186/1755-8166-2-21 doi (DE-627)SPR029575923 (SPR)1755-8166-2-21-e DE-627 ger DE-627 rakwb eng Al Achkar, Walid verfasserin aut Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Al Achkar et al; licensee BioMed Central Ltd. 2009 Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213 Wafa, Abdulsamad aut Mkrtchyan, Hasmik aut Moassass, Faten aut Liehr, Thomas aut Enthalten in Molecular cytogenetics London : BioMed Central, 2008 2(2009), 1 vom: 09. Nov. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:2 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1755-8166-2-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1 09 11
allfields_unstemmed	10.1186/1755-8166-2-21 doi (DE-627)SPR029575923 (SPR)1755-8166-2-21-e DE-627 ger DE-627 rakwb eng Al Achkar, Walid verfasserin aut Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Al Achkar et al; licensee BioMed Central Ltd. 2009 Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213 Wafa, Abdulsamad aut Mkrtchyan, Hasmik aut Moassass, Faten aut Liehr, Thomas aut Enthalten in Molecular cytogenetics London : BioMed Central, 2008 2(2009), 1 vom: 09. Nov. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:2 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1755-8166-2-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1 09 11
allfieldsGer	10.1186/1755-8166-2-21 doi (DE-627)SPR029575923 (SPR)1755-8166-2-21-e DE-627 ger DE-627 rakwb eng Al Achkar, Walid verfasserin aut Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Al Achkar et al; licensee BioMed Central Ltd. 2009 Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213 Wafa, Abdulsamad aut Mkrtchyan, Hasmik aut Moassass, Faten aut Liehr, Thomas aut Enthalten in Molecular cytogenetics London : BioMed Central, 2008 2(2009), 1 vom: 09. Nov. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:2 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1755-8166-2-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1 09 11
allfieldsSound	10.1186/1755-8166-2-21 doi (DE-627)SPR029575923 (SPR)1755-8166-2-21-e DE-627 ger DE-627 rakwb eng Al Achkar, Walid verfasserin aut Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Al Achkar et al; licensee BioMed Central Ltd. 2009 Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213 Wafa, Abdulsamad aut Mkrtchyan, Hasmik aut Moassass, Faten aut Liehr, Thomas aut Enthalten in Molecular cytogenetics London : BioMed Central, 2008 2(2009), 1 vom: 09. Nov. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:2 year:2009 number:1 day:09 month:11 https://dx.doi.org/10.1186/1755-8166-2-21 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2009 1 09 11
language	English
source	Enthalten in Molecular cytogenetics 2(2009), 1 vom: 09. Nov. volume:2 year:2009 number:1 day:09 month:11
sourceStr	Enthalten in Molecular cytogenetics 2(2009), 1 vom: 09. Nov. volume:2 year:2009 number:1 day:09 month:11
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institution	findex.gbv.de
topic_facet	Imatinib Chronic Myeloid Leukemia Clonal Evolution Complex Translocation Variant Translocation
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container_title	Molecular cytogenetics
authorswithroles_txt_mv	Al Achkar, Walid @@aut@@ Wafa, Abdulsamad @@aut@@ Mkrtchyan, Hasmik @@aut@@ Moassass, Faten @@aut@@ Liehr, Thomas @@aut@@
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author	Al Achkar, Walid
spellingShingle	Al Achkar, Walid misc Imatinib misc Chronic Myeloid Leukemia misc Clonal Evolution misc Complex Translocation misc Variant Translocation Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
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topic_title	Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report Imatinib (dpeaa)DE-He213 Chronic Myeloid Leukemia (dpeaa)DE-He213 Clonal Evolution (dpeaa)DE-He213 Complex Translocation (dpeaa)DE-He213 Variant Translocation (dpeaa)DE-He213
topic	misc Imatinib misc Chronic Myeloid Leukemia misc Clonal Evolution misc Complex Translocation misc Variant Translocation
topic_unstemmed	misc Imatinib misc Chronic Myeloid Leukemia misc Clonal Evolution misc Complex Translocation misc Variant Translocation
topic_browse	misc Imatinib misc Chronic Myeloid Leukemia misc Clonal Evolution misc Complex Translocation misc Variant Translocation
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title	Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
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title_full	Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
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author_browse	Al Achkar, Walid Wafa, Abdulsamad Mkrtchyan, Hasmik Moassass, Faten Liehr, Thomas
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title_sort	novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with philadelphia chromosome: a case report
title_auth	Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
abstract	Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. © Al Achkar et al; licensee BioMed Central Ltd. 2009
abstractGer	Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. © Al Achkar et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background The well-known typical fusion gene BCR/ABL can be observed in connection with a complex translocation event in only 2-10% of cases with chronic myeloid leukemia (CML). As currently most CML cases are treated with Imatinib, variant rearrangements have in general no specific prognostic significance, though the emergence of therapy resistance remains to be studied. Results Here we report an exceptional CML case with complex chromosomal aberrations not observed before, involving a 5 chromosome translocation implying chromosomal regions such as 1q42, 4p14 and 5q31 besides 9q34 and 22q11.2. Conclusion The reported rearrangement developed most probably in one initial step and had no influence on a good response during Imatinib treatment. © Al Achkar et al; licensee BioMed Central Ltd. 2009
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title_short	Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report
url	https://dx.doi.org/10.1186/1755-8166-2-21
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author2	Wafa, Abdulsamad Mkrtchyan, Hasmik Moassass, Faten Liehr, Thomas
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Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report

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