Is DNA methylation the new guardian of the genome?

Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivatio...
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Autor*in:	Hoffman, Robert M. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Methionine Methionine dependence Unbalanced transmethylation Global DNA hypomethylation Chromosome instability Aneuploidy Cancer speciation

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: Molecular cytogenetics - London : BioMed Central, 2008, 10(2017), 1 vom: 04. Apr.
Übergeordnetes Werk:	volume:10 ; year:2017 ; number:1 ; day:04 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s13039-017-0314-8

Katalog-ID:	SPR029583489

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520			\|a Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.”
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allfields	10.1186/s13039-017-0314-8 doi (DE-627)SPR029583489 (SPR)s13039-017-0314-8-e DE-627 ger DE-627 rakwb eng Hoffman, Robert M. verfasserin aut Is DNA methylation the new guardian of the genome? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213 Enthalten in Molecular cytogenetics London : BioMed Central, 2008 10(2017), 1 vom: 04. Apr. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:10 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13039-017-0314-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2017 1 04 04
spelling	10.1186/s13039-017-0314-8 doi (DE-627)SPR029583489 (SPR)s13039-017-0314-8-e DE-627 ger DE-627 rakwb eng Hoffman, Robert M. verfasserin aut Is DNA methylation the new guardian of the genome? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213 Enthalten in Molecular cytogenetics London : BioMed Central, 2008 10(2017), 1 vom: 04. Apr. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:10 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13039-017-0314-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2017 1 04 04
allfields_unstemmed	10.1186/s13039-017-0314-8 doi (DE-627)SPR029583489 (SPR)s13039-017-0314-8-e DE-627 ger DE-627 rakwb eng Hoffman, Robert M. verfasserin aut Is DNA methylation the new guardian of the genome? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213 Enthalten in Molecular cytogenetics London : BioMed Central, 2008 10(2017), 1 vom: 04. Apr. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:10 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13039-017-0314-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2017 1 04 04
allfieldsGer	10.1186/s13039-017-0314-8 doi (DE-627)SPR029583489 (SPR)s13039-017-0314-8-e DE-627 ger DE-627 rakwb eng Hoffman, Robert M. verfasserin aut Is DNA methylation the new guardian of the genome? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213 Enthalten in Molecular cytogenetics London : BioMed Central, 2008 10(2017), 1 vom: 04. Apr. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:10 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13039-017-0314-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2017 1 04 04
allfieldsSound	10.1186/s13039-017-0314-8 doi (DE-627)SPR029583489 (SPR)s13039-017-0314-8-e DE-627 ger DE-627 rakwb eng Hoffman, Robert M. verfasserin aut Is DNA methylation the new guardian of the genome? 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213 Enthalten in Molecular cytogenetics London : BioMed Central, 2008 10(2017), 1 vom: 04. Apr. (DE-627)562079963 (DE-600)2420849-8 1755-8166 nnns volume:10 year:2017 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13039-017-0314-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2017 1 04 04
language	English
source	Enthalten in Molecular cytogenetics 10(2017), 1 vom: 04. Apr. volume:10 year:2017 number:1 day:04 month:04
sourceStr	Enthalten in Molecular cytogenetics 10(2017), 1 vom: 04. Apr. volume:10 year:2017 number:1 day:04 month:04
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topic_facet	Methionine Methionine dependence Unbalanced transmethylation Global DNA hypomethylation Chromosome instability Aneuploidy Cancer speciation
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container_title	Molecular cytogenetics
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The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. 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author	Hoffman, Robert M.
spellingShingle	Hoffman, Robert M. misc Methionine misc Methionine dependence misc Unbalanced transmethylation misc Global DNA hypomethylation misc Chromosome instability misc Aneuploidy misc Cancer speciation Is DNA methylation the new guardian of the genome?
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topic_title	Is DNA methylation the new guardian of the genome? Methionine (dpeaa)DE-He213 Methionine dependence (dpeaa)DE-He213 Unbalanced transmethylation (dpeaa)DE-He213 Global DNA hypomethylation (dpeaa)DE-He213 Chromosome instability (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Cancer speciation (dpeaa)DE-He213
topic	misc Methionine misc Methionine dependence misc Unbalanced transmethylation misc Global DNA hypomethylation misc Chromosome instability misc Aneuploidy misc Cancer speciation
topic_unstemmed	misc Methionine misc Methionine dependence misc Unbalanced transmethylation misc Global DNA hypomethylation misc Chromosome instability misc Aneuploidy misc Cancer speciation
topic_browse	misc Methionine misc Methionine dependence misc Unbalanced transmethylation misc Global DNA hypomethylation misc Chromosome instability misc Aneuploidy misc Cancer speciation
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title	Is DNA methylation the new guardian of the genome?
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title_full	Is DNA methylation the new guardian of the genome?
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title_sort	is dna methylation the new guardian of the genome?
title_auth	Is DNA methylation the new guardian of the genome?
abstract	Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” © The Author(s). 2017
abstractGer	Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” © The Author(s). 2017
abstract_unstemmed	Background It has been known for more than 100 years that aneuploidy is an essence of cancer. The question is what keeps the genome stable, thereby preventing aneuploidy. For the past 25 years, it has been proposed that p53 is the “guardian of the genome.” However, it has been shown that inactivation of p53 does not cause aneuploidy. Another essence of cancer is global DNA hypomethylation, which causes destabilization of the genome and subsequent aneupoloidy. Yet, another essence of cancer is excessive use of methionine, resulting in methionine dependence. Methionine dependence is due to possible “metabolic reprogramming” due to carcinogens, including chemical agents and infectious organisms, such as Helicobacter pylori, that result in altered and excessive transmethylation in cancer cells. Cancer cells appear to have a “methyl-sink” whereby methyl groups are diverted from DNA. Conclusion DNA hypomethylation destabilizes the genome, leading to aneuploidy and subsequent selection and speciation into autonomous cancers, leading to the conclusion that DNA methylation is the “guardian of the genome.” © The Author(s). 2017
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title_short	Is DNA methylation the new guardian of the genome?
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