MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells

Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jiang, Ping [verfasserIn] Rao, En Y Meng, Na Zhao, Yong Wang, Jun J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Mantle Cell Lymphoma Mantle Cell Lymphoma Cell Calcium Phosphate Method Mantle Cell Lymphoma Patient HEK293T Cell Line

Anmerkung:	© Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 5(2010), 1 vom: 01. Nov.
Übergeordnetes Werk:	volume:5 ; year:2010 ; number:1 ; day:01 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1748-717X-5-100

Katalog-ID:	SPR029586046

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520			\|a Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic.
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matchkey_str	article:1748717X:2010----::irra72infcnlehnerdoeitnenuam
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allfields	10.1186/1748-717X-5-100 doi (DE-627)SPR029586046 (SPR)1748-717X-5-100-e DE-627 ger DE-627 rakwb eng Jiang, Ping verfasserin aut MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213 Rao, En Y aut Meng, Na aut Zhao, Yong aut Wang, Jun J aut Enthalten in Radiation oncology London : BioMed Central, 2006 5(2010), 1 vom: 01. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:5 year:2010 number:1 day:01 month:11 https://dx.doi.org/10.1186/1748-717X-5-100 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 1 01 11
spelling	10.1186/1748-717X-5-100 doi (DE-627)SPR029586046 (SPR)1748-717X-5-100-e DE-627 ger DE-627 rakwb eng Jiang, Ping verfasserin aut MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213 Rao, En Y aut Meng, Na aut Zhao, Yong aut Wang, Jun J aut Enthalten in Radiation oncology London : BioMed Central, 2006 5(2010), 1 vom: 01. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:5 year:2010 number:1 day:01 month:11 https://dx.doi.org/10.1186/1748-717X-5-100 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 1 01 11
allfields_unstemmed	10.1186/1748-717X-5-100 doi (DE-627)SPR029586046 (SPR)1748-717X-5-100-e DE-627 ger DE-627 rakwb eng Jiang, Ping verfasserin aut MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213 Rao, En Y aut Meng, Na aut Zhao, Yong aut Wang, Jun J aut Enthalten in Radiation oncology London : BioMed Central, 2006 5(2010), 1 vom: 01. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:5 year:2010 number:1 day:01 month:11 https://dx.doi.org/10.1186/1748-717X-5-100 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 1 01 11
allfieldsGer	10.1186/1748-717X-5-100 doi (DE-627)SPR029586046 (SPR)1748-717X-5-100-e DE-627 ger DE-627 rakwb eng Jiang, Ping verfasserin aut MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213 Rao, En Y aut Meng, Na aut Zhao, Yong aut Wang, Jun J aut Enthalten in Radiation oncology London : BioMed Central, 2006 5(2010), 1 vom: 01. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:5 year:2010 number:1 day:01 month:11 https://dx.doi.org/10.1186/1748-717X-5-100 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 1 01 11
allfieldsSound	10.1186/1748-717X-5-100 doi (DE-627)SPR029586046 (SPR)1748-717X-5-100-e DE-627 ger DE-627 rakwb eng Jiang, Ping verfasserin aut MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213 Rao, En Y aut Meng, Na aut Zhao, Yong aut Wang, Jun J aut Enthalten in Radiation oncology London : BioMed Central, 2006 5(2010), 1 vom: 01. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:5 year:2010 number:1 day:01 month:11 https://dx.doi.org/10.1186/1748-717X-5-100 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2010 1 01 11
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author	Jiang, Ping
spellingShingle	Jiang, Ping misc Mantle Cell Lymphoma misc Mantle Cell Lymphoma Cell misc Calcium Phosphate Method misc Mantle Cell Lymphoma Patient misc HEK293T Cell Line MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
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topic_title	MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells Mantle Cell Lymphoma (dpeaa)DE-He213 Mantle Cell Lymphoma Cell (dpeaa)DE-He213 Calcium Phosphate Method (dpeaa)DE-He213 Mantle Cell Lymphoma Patient (dpeaa)DE-He213 HEK293T Cell Line (dpeaa)DE-He213
topic	misc Mantle Cell Lymphoma misc Mantle Cell Lymphoma Cell misc Calcium Phosphate Method misc Mantle Cell Lymphoma Patient misc HEK293T Cell Line
topic_unstemmed	misc Mantle Cell Lymphoma misc Mantle Cell Lymphoma Cell misc Calcium Phosphate Method misc Mantle Cell Lymphoma Patient misc HEK293T Cell Line
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title	MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
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title_full	MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
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author_browse	Jiang, Ping Rao, En Y Meng, Na Zhao, Yong Wang, Jun J
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title_sort	microrna-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
title_auth	MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
abstract	Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract The microRNA-17-92 (miRNA-17-92) cluster, at chromosome 13q31-q32, also known as oncomir-1, consists of seven miRNAs that are transcribed as a polycistronic unit. Over-expression of miRNA-17-92 has been observed in lymphomas and other solid tumors. Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the effects of miRNA-17-92 on the radiosensitivity of human mantle cell lymphoma (MCL) cells Z138c. Over-expression of miRNA-17-92 significantly increased survival cell number, cell proliferation and decreased cell death of human MCL cells after different doses of radiation. Immunoblot analysis showed that phosphatase and tension homolog (PTEN) and PHLPP2 was down-modulated and pAkt activity was enhanced in MCL cells after over-expressing miRNA-17-92 after irradiation. These findings are the first direct evidence that over-expression of miRNA-17-92 cluster significantly increases the radioresistance of human MCL cells, which offers a novel target molecule for improving the radiotherapy of MCL in clinic. © Jiang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells
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MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells

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