Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Huber, Reinhard [verfasserIn] Braselmann, Herbert Geinitz, Hans Jaehnert, Irene Baumgartner, Adolf Thamm, Reinhard Figel, Markus Molls, Michael Zitzelsberger, Horst

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Chromosome Aberration Painted Chromosome Aberration Frequency Premature Chromosome Condensation Aberration Type

Anmerkung:	© Huber et al; licensee BioMed Central Ltd. 2011

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 6(2011), 1 vom: 07. Apr.
Übergeordnetes Werk:	volume:6 ; year:2011 ; number:1 ; day:07 ; month:04

Links:	Volltext

DOI / URN:	10.1186/1748-717X-6-32

Katalog-ID:	SPR029591821

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520			\|a Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity.
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author_variant	r h rh h b hb h g hg i j ij a b ab r t rt m f mf m m mm h z hz
matchkey_str	article:1748717X:2011----::hoooardoestvtadctrdainiefetatraiteayn
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allfields	10.1186/1748-717X-6-32 doi (DE-627)SPR029591821 (SPR)1748-717X-6-32-e DE-627 ger DE-627 rakwb eng Huber, Reinhard verfasserin aut Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Huber et al; licensee BioMed Central Ltd. 2011 Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213 Braselmann, Herbert aut Geinitz, Hans aut Jaehnert, Irene aut Baumgartner, Adolf aut Thamm, Reinhard aut Figel, Markus aut Molls, Michael aut Zitzelsberger, Horst aut Enthalten in Radiation oncology London : BioMed Central, 2006 6(2011), 1 vom: 07. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:6 year:2011 number:1 day:07 month:04 https://dx.doi.org/10.1186/1748-717X-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 07 04
spelling	10.1186/1748-717X-6-32 doi (DE-627)SPR029591821 (SPR)1748-717X-6-32-e DE-627 ger DE-627 rakwb eng Huber, Reinhard verfasserin aut Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Huber et al; licensee BioMed Central Ltd. 2011 Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213 Braselmann, Herbert aut Geinitz, Hans aut Jaehnert, Irene aut Baumgartner, Adolf aut Thamm, Reinhard aut Figel, Markus aut Molls, Michael aut Zitzelsberger, Horst aut Enthalten in Radiation oncology London : BioMed Central, 2006 6(2011), 1 vom: 07. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:6 year:2011 number:1 day:07 month:04 https://dx.doi.org/10.1186/1748-717X-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 07 04
allfields_unstemmed	10.1186/1748-717X-6-32 doi (DE-627)SPR029591821 (SPR)1748-717X-6-32-e DE-627 ger DE-627 rakwb eng Huber, Reinhard verfasserin aut Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Huber et al; licensee BioMed Central Ltd. 2011 Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213 Braselmann, Herbert aut Geinitz, Hans aut Jaehnert, Irene aut Baumgartner, Adolf aut Thamm, Reinhard aut Figel, Markus aut Molls, Michael aut Zitzelsberger, Horst aut Enthalten in Radiation oncology London : BioMed Central, 2006 6(2011), 1 vom: 07. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:6 year:2011 number:1 day:07 month:04 https://dx.doi.org/10.1186/1748-717X-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 07 04
allfieldsGer	10.1186/1748-717X-6-32 doi (DE-627)SPR029591821 (SPR)1748-717X-6-32-e DE-627 ger DE-627 rakwb eng Huber, Reinhard verfasserin aut Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Huber et al; licensee BioMed Central Ltd. 2011 Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213 Braselmann, Herbert aut Geinitz, Hans aut Jaehnert, Irene aut Baumgartner, Adolf aut Thamm, Reinhard aut Figel, Markus aut Molls, Michael aut Zitzelsberger, Horst aut Enthalten in Radiation oncology London : BioMed Central, 2006 6(2011), 1 vom: 07. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:6 year:2011 number:1 day:07 month:04 https://dx.doi.org/10.1186/1748-717X-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 07 04
allfieldsSound	10.1186/1748-717X-6-32 doi (DE-627)SPR029591821 (SPR)1748-717X-6-32-e DE-627 ger DE-627 rakwb eng Huber, Reinhard verfasserin aut Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Huber et al; licensee BioMed Central Ltd. 2011 Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213 Braselmann, Herbert aut Geinitz, Hans aut Jaehnert, Irene aut Baumgartner, Adolf aut Thamm, Reinhard aut Figel, Markus aut Molls, Michael aut Zitzelsberger, Horst aut Enthalten in Radiation oncology London : BioMed Central, 2006 6(2011), 1 vom: 07. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:6 year:2011 number:1 day:07 month:04 https://dx.doi.org/10.1186/1748-717X-6-32 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2011 1 07 04
language	English
source	Enthalten in Radiation oncology 6(2011), 1 vom: 07. Apr. volume:6 year:2011 number:1 day:07 month:04
sourceStr	Enthalten in Radiation oncology 6(2011), 1 vom: 07. Apr. volume:6 year:2011 number:1 day:07 month:04
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topic_facet	Chromosome Aberration Painted Chromosome Aberration Frequency Premature Chromosome Condensation Aberration Type
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container_title	Radiation oncology
authorswithroles_txt_mv	Huber, Reinhard @@aut@@ Braselmann, Herbert @@aut@@ Geinitz, Hans @@aut@@ Jaehnert, Irene @@aut@@ Baumgartner, Adolf @@aut@@ Thamm, Reinhard @@aut@@ Figel, Markus @@aut@@ Molls, Michael @@aut@@ Zitzelsberger, Horst @@aut@@
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author	Huber, Reinhard
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topic_title	Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study Chromosome Aberration (dpeaa)DE-He213 Painted Chromosome (dpeaa)DE-He213 Aberration Frequency (dpeaa)DE-He213 Premature Chromosome Condensation (dpeaa)DE-He213 Aberration Type (dpeaa)DE-He213
topic	misc Chromosome Aberration misc Painted Chromosome misc Aberration Frequency misc Premature Chromosome Condensation misc Aberration Type
topic_unstemmed	misc Chromosome Aberration misc Painted Chromosome misc Aberration Frequency misc Premature Chromosome Condensation misc Aberration Type
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title	Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
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title_full	Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
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author_browse	Huber, Reinhard Braselmann, Herbert Geinitz, Hans Jaehnert, Irene Baumgartner, Adolf Thamm, Reinhard Figel, Markus Molls, Michael Zitzelsberger, Horst
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title_sort	chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
title_auth	Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
abstract	Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. © Huber et al; licensee BioMed Central Ltd. 2011
abstractGer	Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. © Huber et al; licensee BioMed Central Ltd. 2011
abstract_unstemmed	Background Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. Conclusions The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity. © Huber et al; licensee BioMed Central Ltd. 2011
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title_short	Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study
url	https://dx.doi.org/10.1186/1748-717X-6-32
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author2	Braselmann, Herbert Geinitz, Hans Jaehnert, Irene Baumgartner, Adolf Thamm, Reinhard Figel, Markus Molls, Michael Zitzelsberger, Horst
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It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. Methods Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. Results Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. 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Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

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