Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases

Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ingrosso, Gianluca [verfasserIn] Miceli, Roberto Fedele, Dahlia Ponti, Elisabetta Benassi, Michaela Barbarino, Rosaria Di Murro, Luana Giudice, Emilia Santarelli, Federico Santoni, Riccardo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Brain Metastasis Plan Target Volume Gross Tumour Volume Stereotactic Radiotherapy Rotational Error

Anmerkung:	© Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 7(2012), 1 vom: 01. Apr.
Übergeordnetes Werk:	volume:7 ; year:2012 ; number:1 ; day:01 ; month:04

Links:	Volltext

DOI / URN:	10.1186/1748-717X-7-54

Katalog-ID:	SPR029615070

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520			\|a Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position.
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700	1		\|a Santoni, Riccardo \|4 aut
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author_variant	g i gi r m rm d f df e p ep m b mb r b rb m l d ml mld e g eg f s fs r s rs
matchkey_str	article:1748717X:2012----::oeemoptdoorpynyorcintdtroatcait
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allfields	10.1186/1748-717X-7-54 doi (DE-627)SPR029615070 (SPR)1748-717X-7-54-e DE-627 ger DE-627 rakwb eng Ingrosso, Gianluca verfasserin aut Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213 Miceli, Roberto aut Fedele, Dahlia aut Ponti, Elisabetta aut Benassi, Michaela aut Barbarino, Rosaria aut Di Murro, Luana aut Giudice, Emilia aut Santarelli, Federico aut Santoni, Riccardo aut Enthalten in Radiation oncology London : BioMed Central, 2006 7(2012), 1 vom: 01. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:7 year:2012 number:1 day:01 month:04 https://dx.doi.org/10.1186/1748-717X-7-54 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1 01 04
spelling	10.1186/1748-717X-7-54 doi (DE-627)SPR029615070 (SPR)1748-717X-7-54-e DE-627 ger DE-627 rakwb eng Ingrosso, Gianluca verfasserin aut Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213 Miceli, Roberto aut Fedele, Dahlia aut Ponti, Elisabetta aut Benassi, Michaela aut Barbarino, Rosaria aut Di Murro, Luana aut Giudice, Emilia aut Santarelli, Federico aut Santoni, Riccardo aut Enthalten in Radiation oncology London : BioMed Central, 2006 7(2012), 1 vom: 01. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:7 year:2012 number:1 day:01 month:04 https://dx.doi.org/10.1186/1748-717X-7-54 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1 01 04
allfields_unstemmed	10.1186/1748-717X-7-54 doi (DE-627)SPR029615070 (SPR)1748-717X-7-54-e DE-627 ger DE-627 rakwb eng Ingrosso, Gianluca verfasserin aut Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213 Miceli, Roberto aut Fedele, Dahlia aut Ponti, Elisabetta aut Benassi, Michaela aut Barbarino, Rosaria aut Di Murro, Luana aut Giudice, Emilia aut Santarelli, Federico aut Santoni, Riccardo aut Enthalten in Radiation oncology London : BioMed Central, 2006 7(2012), 1 vom: 01. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:7 year:2012 number:1 day:01 month:04 https://dx.doi.org/10.1186/1748-717X-7-54 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1 01 04
allfieldsGer	10.1186/1748-717X-7-54 doi (DE-627)SPR029615070 (SPR)1748-717X-7-54-e DE-627 ger DE-627 rakwb eng Ingrosso, Gianluca verfasserin aut Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213 Miceli, Roberto aut Fedele, Dahlia aut Ponti, Elisabetta aut Benassi, Michaela aut Barbarino, Rosaria aut Di Murro, Luana aut Giudice, Emilia aut Santarelli, Federico aut Santoni, Riccardo aut Enthalten in Radiation oncology London : BioMed Central, 2006 7(2012), 1 vom: 01. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:7 year:2012 number:1 day:01 month:04 https://dx.doi.org/10.1186/1748-717X-7-54 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1 01 04
allfieldsSound	10.1186/1748-717X-7-54 doi (DE-627)SPR029615070 (SPR)1748-717X-7-54-e DE-627 ger DE-627 rakwb eng Ingrosso, Gianluca verfasserin aut Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213 Miceli, Roberto aut Fedele, Dahlia aut Ponti, Elisabetta aut Benassi, Michaela aut Barbarino, Rosaria aut Di Murro, Luana aut Giudice, Emilia aut Santarelli, Federico aut Santoni, Riccardo aut Enthalten in Radiation oncology London : BioMed Central, 2006 7(2012), 1 vom: 01. Apr. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:7 year:2012 number:1 day:01 month:04 https://dx.doi.org/10.1186/1748-717X-7-54 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1 01 04
language	English
source	Enthalten in Radiation oncology 7(2012), 1 vom: 01. Apr. volume:7 year:2012 number:1 day:01 month:04
sourceStr	Enthalten in Radiation oncology 7(2012), 1 vom: 01. Apr. volume:7 year:2012 number:1 day:01 month:04
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Brain Metastasis Plan Target Volume Gross Tumour Volume Stereotactic Radiotherapy Rotational Error
isfreeaccess_bool	true
container_title	Radiation oncology
authorswithroles_txt_mv	Ingrosso, Gianluca @@aut@@ Miceli, Roberto @@aut@@ Fedele, Dahlia @@aut@@ Ponti, Elisabetta @@aut@@ Benassi, Michaela @@aut@@ Barbarino, Rosaria @@aut@@ Di Murro, Luana @@aut@@ Giudice, Emilia @@aut@@ Santarelli, Federico @@aut@@ Santoni, Riccardo @@aut@@
publishDateDaySort_date	2012-04-01T00:00:00Z
hierarchy_top_id	508725739
id	SPR029615070
language_de	englisch
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain Metastasis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plan Target Volume</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gross Tumour Volume</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stereotactic Radiotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rotational Error</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Miceli, Roberto</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fedele, Dahlia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ponti, Elisabetta</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benassi, Michaela</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barbarino, Rosaria</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Murro, Luana</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giudice, Emilia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santarelli, Federico</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santoni, Riccardo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Radiation oncology</subfield><subfield code="d">London : BioMed Central, 2006</subfield><subfield code="g">7(2012), 1 vom: 01. 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author	Ingrosso, Gianluca
spellingShingle	Ingrosso, Gianluca misc Brain Metastasis misc Plan Target Volume misc Gross Tumour Volume misc Stereotactic Radiotherapy misc Rotational Error Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
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topic_title	Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases Brain Metastasis (dpeaa)DE-He213 Plan Target Volume (dpeaa)DE-He213 Gross Tumour Volume (dpeaa)DE-He213 Stereotactic Radiotherapy (dpeaa)DE-He213 Rotational Error (dpeaa)DE-He213
topic	misc Brain Metastasis misc Plan Target Volume misc Gross Tumour Volume misc Stereotactic Radiotherapy misc Rotational Error
topic_unstemmed	misc Brain Metastasis misc Plan Target Volume misc Gross Tumour Volume misc Stereotactic Radiotherapy misc Rotational Error
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title	Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
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title_full	Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
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author_browse	Ingrosso, Gianluca Miceli, Roberto Fedele, Dahlia Ponti, Elisabetta Benassi, Michaela Barbarino, Rosaria Di Murro, Luana Giudice, Emilia Santarelli, Federico Santoni, Riccardo
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title_sort	cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
title_auth	Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
abstract	Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. Methods 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a combination of a thermoplastic mask and a bite-block fixed to a stereotactic frame support. Daily cone-beam CT scans were acquired for every patient before the treatment session and were matched online with planning CT images, for 3D image registration. The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position. © Ingrosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases
url	https://dx.doi.org/10.1186/1748-717X-7-54
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author2	Miceli, Roberto Fedele, Dahlia Ponti, Elisabetta Benassi, Michaela Barbarino, Rosaria Di Murro, Luana Giudice, Emilia Santarelli, Federico Santoni, Riccardo
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The mean value and standard deviation of all translational (X, Y, Z) and rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were calculated for the matching results of bone matching algorithm. Results A total of 194 CBCT scans were analyzed. Mean +/- standard deviation of translational errors (X, Y, Z) were respectively 0.5 +/- 1.6 mm (range -5.7 and 5.9 mm) in X; 0.4 +/- 2.7 mm (range -8.2 and 12.1 mm) in Y; 0.4 +/- 1.9 mm (range -7.0 and 14 mm) in Z; median and 90th percentile were respectively within 0.5 mm and 2.4 mm in X, 0.3 mm and 3.2 mm in Y, 0.3 mm and 2.2 mm in Z. Mean +/- standard deviation of rotational errors ($ θ_{x} $, θy, $ θ_{z} $) were respectively 0.0 degrees+/- 1.3 degrees ($ θ_{x} $) (range -6.0 degrees and 3.1 degrees); -0.1 degrees +/- 1.1 degrees (θy) (range -3.0 degrees and 2.4 degrees); -0.6 degrees +/- 1.4 degrees ($ θ_{z} $) (range -5.0 degrees and 3.3 degrees). Median and 90th percentile of rotational errors were respectively within 0.1 degrees and 1.4 degrees ($ θ_{x} $), 0.0 degrees and 1.2 degrees (θy), 0.0 degrees and 0.9 degrees ($ θ_{z} $). Mean +/- SD of 3D vector was 3.1 +/- 2.1 mm (range 0.3 and 14.9 mm); median and 90th percentile of 3D vector was within 2.7 mm and 5.1 mm. Conclusions Hypofractionated stereotactic radiotherapy have the significant limitation of uncertainty in interfraction repeatability of the patient setup; image-guided radiotherapy using cone-beam computed tomography improves the accuracy of the treatment delivery reducing set-up uncertainty, giving the possibility of 3-dimensional anatomic informations in the treatment position.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain Metastasis</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plan Target Volume</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gross Tumour Volume</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stereotactic Radiotherapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rotational Error</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Miceli, Roberto</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fedele, Dahlia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ponti, Elisabetta</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benassi, Michaela</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barbarino, Rosaria</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Di Murro, Luana</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giudice, Emilia</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santarelli, Federico</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santoni, Riccardo</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Radiation oncology</subfield><subfield code="d">London : BioMed Central, 2006</subfield><subfield code="g">7(2012), 1 vom: 01. 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Cone-beam computed tomography in hypofractionated stereotactic radiotherapy for brain metastases

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