8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia

Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we id...
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Autor*in:	Chinen, Yoshiaki [verfasserIn] Sakamoto, Natsumi Nagoshi, Hisao Taki, Tomohiko Maegawa, Saori Tatekawa, Shotaro Tsukamoto, Taku Mizutani, Shinsuke Shimura, Yuji Yamamoto-Sugitani, Mio Kobayashi, Tsutomu Matsumoto, Yosuke Horiike, Shigeo Kuroda, Junya Taniwaki, Masafumi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Acute myeloid leukemia (AML) Long noncoding RNAs (lincRNAs) PVT1 NSMCE2 CCDC26

Anmerkung:	© Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Journal of hematology & oncology - London : Biomed Central, 2008, 7(2014), 1 vom: 23. Sept.
Übergeordnetes Werk:	volume:7 ; year:2014 ; number:1 ; day:23 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s13045-014-0068-2

Katalog-ID:	SPR029616875

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allfields	10.1186/s13045-014-0068-2 doi (DE-627)SPR029616875 (SPR)s13045-014-0068-2-e DE-627 ger DE-627 rakwb eng Chinen, Yoshiaki verfasserin aut 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213 Sakamoto, Natsumi aut Nagoshi, Hisao aut Taki, Tomohiko aut Maegawa, Saori aut Tatekawa, Shotaro aut Tsukamoto, Taku aut Mizutani, Shinsuke aut Shimura, Yuji aut Yamamoto-Sugitani, Mio aut Kobayashi, Tsutomu aut Matsumoto, Yosuke aut Horiike, Shigeo aut Kuroda, Junya aut Taniwaki, Masafumi aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 7(2014), 1 vom: 23. Sept. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:7 year:2014 number:1 day:23 month:09 https://dx.doi.org/10.1186/s13045-014-0068-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 23 09
spelling	10.1186/s13045-014-0068-2 doi (DE-627)SPR029616875 (SPR)s13045-014-0068-2-e DE-627 ger DE-627 rakwb eng Chinen, Yoshiaki verfasserin aut 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213 Sakamoto, Natsumi aut Nagoshi, Hisao aut Taki, Tomohiko aut Maegawa, Saori aut Tatekawa, Shotaro aut Tsukamoto, Taku aut Mizutani, Shinsuke aut Shimura, Yuji aut Yamamoto-Sugitani, Mio aut Kobayashi, Tsutomu aut Matsumoto, Yosuke aut Horiike, Shigeo aut Kuroda, Junya aut Taniwaki, Masafumi aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 7(2014), 1 vom: 23. Sept. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:7 year:2014 number:1 day:23 month:09 https://dx.doi.org/10.1186/s13045-014-0068-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 23 09
allfields_unstemmed	10.1186/s13045-014-0068-2 doi (DE-627)SPR029616875 (SPR)s13045-014-0068-2-e DE-627 ger DE-627 rakwb eng Chinen, Yoshiaki verfasserin aut 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213 Sakamoto, Natsumi aut Nagoshi, Hisao aut Taki, Tomohiko aut Maegawa, Saori aut Tatekawa, Shotaro aut Tsukamoto, Taku aut Mizutani, Shinsuke aut Shimura, Yuji aut Yamamoto-Sugitani, Mio aut Kobayashi, Tsutomu aut Matsumoto, Yosuke aut Horiike, Shigeo aut Kuroda, Junya aut Taniwaki, Masafumi aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 7(2014), 1 vom: 23. Sept. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:7 year:2014 number:1 day:23 month:09 https://dx.doi.org/10.1186/s13045-014-0068-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 23 09
allfieldsGer	10.1186/s13045-014-0068-2 doi (DE-627)SPR029616875 (SPR)s13045-014-0068-2-e DE-627 ger DE-627 rakwb eng Chinen, Yoshiaki verfasserin aut 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213 Sakamoto, Natsumi aut Nagoshi, Hisao aut Taki, Tomohiko aut Maegawa, Saori aut Tatekawa, Shotaro aut Tsukamoto, Taku aut Mizutani, Shinsuke aut Shimura, Yuji aut Yamamoto-Sugitani, Mio aut Kobayashi, Tsutomu aut Matsumoto, Yosuke aut Horiike, Shigeo aut Kuroda, Junya aut Taniwaki, Masafumi aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 7(2014), 1 vom: 23. Sept. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:7 year:2014 number:1 day:23 month:09 https://dx.doi.org/10.1186/s13045-014-0068-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 23 09
allfieldsSound	10.1186/s13045-014-0068-2 doi (DE-627)SPR029616875 (SPR)s13045-014-0068-2-e DE-627 ger DE-627 rakwb eng Chinen, Yoshiaki verfasserin aut 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213 Sakamoto, Natsumi aut Nagoshi, Hisao aut Taki, Tomohiko aut Maegawa, Saori aut Tatekawa, Shotaro aut Tsukamoto, Taku aut Mizutani, Shinsuke aut Shimura, Yuji aut Yamamoto-Sugitani, Mio aut Kobayashi, Tsutomu aut Matsumoto, Yosuke aut Horiike, Shigeo aut Kuroda, Junya aut Taniwaki, Masafumi aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 7(2014), 1 vom: 23. Sept. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:7 year:2014 number:1 day:23 month:09 https://dx.doi.org/10.1186/s13045-014-0068-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 23 09
language	English
source	Enthalten in Journal of hematology & oncology 7(2014), 1 vom: 23. Sept. volume:7 year:2014 number:1 day:23 month:09
sourceStr	Enthalten in Journal of hematology & oncology 7(2014), 1 vom: 23. Sept. volume:7 year:2014 number:1 day:23 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Acute myeloid leukemia (AML) Long noncoding RNAs (lincRNAs) PVT1 NSMCE2 CCDC26
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container_title	Journal of hematology & oncology
authorswithroles_txt_mv	Chinen, Yoshiaki @@aut@@ Sakamoto, Natsumi @@aut@@ Nagoshi, Hisao @@aut@@ Taki, Tomohiko @@aut@@ Maegawa, Saori @@aut@@ Tatekawa, Shotaro @@aut@@ Tsukamoto, Taku @@aut@@ Mizutani, Shinsuke @@aut@@ Shimura, Yuji @@aut@@ Yamamoto-Sugitani, Mio @@aut@@ Kobayashi, Tsutomu @@aut@@ Matsumoto, Yosuke @@aut@@ Horiike, Shigeo @@aut@@ Kuroda, Junya @@aut@@ Taniwaki, Masafumi @@aut@@
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author	Chinen, Yoshiaki
spellingShingle	Chinen, Yoshiaki misc Acute myeloid leukemia (AML) misc Long noncoding RNAs (lincRNAs) misc PVT1 misc NSMCE2 misc CCDC26 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
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topic_title	8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia Acute myeloid leukemia (AML) (dpeaa)DE-He213 Long noncoding RNAs (lincRNAs) (dpeaa)DE-He213 PVT1 (dpeaa)DE-He213 NSMCE2 (dpeaa)DE-He213 CCDC26 (dpeaa)DE-He213
topic	misc Acute myeloid leukemia (AML) misc Long noncoding RNAs (lincRNAs) misc PVT1 misc NSMCE2 misc CCDC26
topic_unstemmed	misc Acute myeloid leukemia (AML) misc Long noncoding RNAs (lincRNAs) misc PVT1 misc NSMCE2 misc CCDC26
topic_browse	misc Acute myeloid leukemia (AML) misc Long noncoding RNAs (lincRNAs) misc PVT1 misc NSMCE2 misc CCDC26
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title	8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
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title_full	8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
author_sort	Chinen, Yoshiaki
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author_browse	Chinen, Yoshiaki Sakamoto, Natsumi Nagoshi, Hisao Taki, Tomohiko Maegawa, Saori Tatekawa, Shotaro Tsukamoto, Taku Mizutani, Shinsuke Shimura, Yuji Yamamoto-Sugitani, Mio Kobayashi, Tsutomu Matsumoto, Yosuke Horiike, Shigeo Kuroda, Junya Taniwaki, Masafumi
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title_sort	8q24 amplified segments involve novel fusion genes between nsmce2 and long noncoding rnas in acute myelogenous leukemia
title_auth	8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
abstract	Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles. © Chinen et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (
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title_short	8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia
url	https://dx.doi.org/10.1186/s13045-014-0068-2
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author2	Sakamoto, Natsumi Nagoshi, Hisao Taki, Tomohiko Maegawa, Saori Tatekawa, Shotaro Tsukamoto, Taku Mizutani, Shinsuke Shimura, Yuji Yamamoto-Sugitani, Mio Kobayashi, Tsutomu Matsumoto, Yosuke Horiike, Shigeo Kuroda, Junya Taniwaki, Masafumi
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up_date	2024-07-04T01:43:01.142Z
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. 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8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia

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